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Your search keyword '"Chauveau, Antoine"' showing total 4 results
Start Over Author "Chauveau, Antoine" Topic plant extracts
4 results on '"Chauveau, Antoine"'

1. Immunological evaluation of herbal extracts commonly used for treatment of mental diseases during pregnancy.

Author

Winker M, Chauveau A, Smieško M, Potterat O, Areesanan A, Zimmermann-Klemd A, and Gründemann C

Subjects
Female, Humans, Pregnancy, Phytotherapy, Plant Extracts therapeutic use, Mental Disorders drug therapy, Lymphocytes drug effects
Abstract

Nonpsychotic mental diseases (NMDs) affect approximately 15% of pregnant women in the US. Herbal preparations are perceived a safe alternative to placenta-crossing antidepressants or benzodiazepines in the treatment of nonpsychotic mental diseases. But are these drugs really safe for mother and foetus? This question is of great relevance to physicians and patients. Therefore, this study investigates the influence of St. John's wort, valerian, hops, lavender, and California poppy and their compounds hyperforin and hypericin, protopine, valerenic acid, and valtrate, as well as linalool, on immune modulating effects in vitro. For this purpose a variety of methods was applied to assess the effects on viability and function of human primary lymphocytes. Viability was assessed via spectrometric assessment, flow cytometric detection of cell death markers and comet assay for possible genotoxicity. Functional assessment was conducted via flow cytometric assessment of proliferation, cell cycle and immunophenotyping. For California poppy, lavender, hops, and the compounds protopine and linalool, and valerenic acid, no effect was found on the viability, proliferation, and function of primary human lymphocytes. However, St. John's wort and valerian inhibited the proliferation of primary human lymphocytes. Hyperforin, hypericin, and valtrate inhibited viability, induced apoptosis, and inhibited cell division. Calculated maximum concentration of compounds in the body fluid, as well as calculated concentrations based on pharmacokinetic data from the literature, were low and supported that the observed effects in vitro would probably have no relevance on patients. In-silico analyses comparing the structure of studied substances with the structure of relevant control substances and known immunosuppressants revealed structural similarities of hyperforin and valerenic acid to the glucocorticoids. Valtrate showed structural similarities to the T cells signaling modulating drugs., (© 2023. The Author(s).)

Published
2023
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2. Placental Passage of Protopine in an Ex Vivo Human Perfusion System.

Author

Spiess, Deborah, Abegg, Vanessa Fabienne, Chauveau, Antoine, Treyer, Andrea, Reinehr, Michael, Oufir, Mouhssin, Duong, Elisa, Potterat, Olivier, Hamburger, Matthias, and Simões-Wüst, Ana Paula

Subjects
MATERNAL-fetal exchange, ALKALOIDS, PLACENTA, PLANT extracts, MOLECULAR structure, PERFUSION
Abstract

The placental passage of protopine was investigated with a human ex vivo placental perfusion model. The model was first validated with diazepam and citalopram, 2 compounds known to cross the placental barrier, and antipyrine as a positive control. All compounds were quantified by partially validated U(H)PLC-MS/MS bioanalytical methods. Protopine was transferred from the maternal to the fetal circuit, with a steady-state reached after 90 min. The study compound did not affect placental viability or functionality, as glucose consumption, lactate production, and beta-human chorionic gonadotropin, and leptin release remained constant. Histopathological evaluation of all placental specimens showed unremarkable, age-appropriate parenchymal maturation with no pathologic findings. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System#.

Author

Spiess, Deborah, Abegg, Vanessa Fabienne, Chauveau, Antoine, Treyer, Andrea, Reinehr, Michael, Oufir, Mouhssin, Duong, Elisa, Potterat, Olivier, Hamburger, Matthias, and Simões-Wüst, Ana Paula

Subjects
BIOLOGICAL models, CITALOPRAM, MATERNAL-fetal exchange, ALKALOIDS, CELL survival, GONADOTROPIN, PLACENTA, MASS spectrometry, DESCRIPTIVE statistics, PLANT extracts, MOLECULAR structure, PERFUSION, DIAZEPAM
Abstract

The placental passage of humulone and protopine was investigated with a human ex vivo placental perfusion model. The model was first validated with diazepam and citalopram, 2 compounds known to cross the placental barrier, and antipyrine as a positive control. All compounds were quantified by partially validated U(H)PLC-MS/MS bioanalytical methods. Only a small portion of humulone initially present in the maternal circuit reached the fetal circuit. The humulone concentration in the maternal circuit rapidly decreased, likely due to metabolization in the placenta. Protopine was transferred from the maternal to the fetal circuit, with a steady-state reached after 90 min. None of the study compounds affected placental viability or functionality, as glucose consumption, lactate production, beta-human chorionic gonadotropin, and leptin release remained constant. Histopathological evaluation of all placental specimens showed unremarkable, age-appropriate parenchymal maturation with no pathologic findings. [ABSTRACT FROM AUTHOR]

Published
2021
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4. Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System#.

Author

Spiess, Deborah, Abegg, Vanessa Fabienne, Chauveau, Antoine, Treyer, Andrea, Reinehr, Michael, Oufir, Mouhssin, Duong, Elisa, Potterat, Olivier, Hamburger, Matthias, and Simões-Wüst, Ana Paula

Subjects
*BIOLOGICAL models, *CITALOPRAM, *MATERNAL-fetal exchange, *ALKALOIDS, *CELL survival, *GONADOTROPIN, *PLACENTA, *MASS spectrometry, *DESCRIPTIVE statistics, *PLANT extracts, *MOLECULAR structure, *PERFUSION, *DIAZEPAM
Abstract

The placental passage of humulone and protopine was investigated with a human ex vivo placental perfusion model. The model was first validated with diazepam and citalopram, 2 compounds known to cross the placental barrier, and antipyrine as a positive control. All compounds were quantified by partially validated U(H)PLC-MS/MS bioanalytical methods. Only a small portion of humulone initially present in the maternal circuit reached the fetal circuit. The humulone concentration in the maternal circuit rapidly decreased, likely due to metabolization in the placenta. Protopine was transferred from the maternal to the fetal circuit, with a steady-state reached after 90 min. None of the study compounds affected placental viability or functionality, as glucose consumption, lactate production, beta-human chorionic gonadotropin, and leptin release remained constant. Histopathological evaluation of all placental specimens showed unremarkable, age-appropriate parenchymal maturation with no pathologic findings. [ABSTRACT FROM AUTHOR]

Published
2021
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