1. Effects of the diluent type on compressional characteristics of the mixed stem bark extract of Anogeissus leiocarpus and Prosopis africana tablet formulation.
- Author
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Isimi CY, Nasipuri RN, Ojile JB, Ibrahim YK, and Emeje M
- Subjects
- Adjuvants, Pharmaceutic, Asthma drug therapy, Chemistry, Pharmaceutical, Medicine, African Traditional, Nigeria, Plant Extracts administration & dosage, Plant Extracts chemistry, Plant Extracts therapeutic use, Water, Combretaceae, Excipients, Plant Bark chemistry, Plant Stems chemistry, Prosopis, Tablets
- Abstract
The hot water extract of a mixture of stem barks of Anogeissus leiocarpus and Prosopis africana was formulated into tablets using the wet granulation method of massing and screening. The Heckel equation was used to study the compaction characteristics of the extract formulated with lactose (water-soluble) or magnesium carbonate (water-insoluble) as diluents. Granules prepared using magnesium carbonate were found to exhibit two stages of deformation - an initial fragmentation followed by plastic flow while those formulated with lactose consolidated mainly by plastic deformation. Compressibility profiles of the formulations were affected by the diluent type. Tensile strength of granules formulated with magnesium carbonate was found to increase as the compression pressure increased from 56.6 to 113.2 MN m(-2) while the tensile strength of tablets formulated with lactose had its maximum at a compression force of 84.9 MN m(-2).
- Published
- 2003