1. Understanding the intersection between placental development and cancer: Lessons from the tumor suppressor BAP1.
- Author
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Doria-Borrell P and Pérez-García V
- Subjects
- Female, Humans, Pregnancy, Animals, Placenta metabolism, Tumor Suppressor Proteins metabolism, Tumor Suppressor Proteins genetics, Placentation, Neoplasms genetics, Neoplasms metabolism, Neoplasms etiology, Neoplasms pathology, Ubiquitin Thiolesterase metabolism, Ubiquitin Thiolesterase genetics
- Abstract
The placenta, a pivotal organ in mammalian reproduction, allows nutrient exchange and hormonal signaling between the mother and the developing fetus. Understanding its molecular intricacies is essential for deciphering normal embryonic development and pathological conditions such as tumorigenesis. Here, we explore the multifaceted role of the tumor suppressor BRCA1-associated protein 1 (BAP1) in cancer and placentation. Initially recognized for its tumor-suppressive properties, BAP1 has emerged as a key regulator at the intersection of tumorigenesis and placental development. BAP1 influences crucial cellular processes such as cell death, proliferation, metabolism, and response to hypoxic conditions. By integrating insights from tumor and developmental biology, we illuminate the complex molecular pathways orchestrated by BAP1. This perspective highlights BAP1's significant impact on both cancer and placental development, and suggests novel therapeutic strategies that could improve outcomes for pregnancy disorders and cancer., (© 2024. The Author(s).)
- Published
- 2024
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