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Abstract: A series of 4-(7,7-dimethyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl)morpholine substituted sulfonamide and urea derivatives has been synthesized and characterized using spectral techniques. The antiviral activity of these compounds against an avian paramyxo virus (AMPV-1) was screened using MTT assay and found that one of the sulfonamide derivatives (2d) show three-fold higher antiviral activity than Ribavirin, a commercial antiviral drug substance.Graphical abstract: [ABSTRACT FROM AUTHOR]

A series of six novel 1-(7,7-dimethyl-2-morpholino-5,6,7,8-tetrahydroquinazolin-4-yl)piperidine-4-carboxamide derivatives has been synthesized and characterized using various spectral techniques (H and C NMR, LCMS, IR). The antibacterial activities of these compounds have been screened against nine different Gram-positive and Gram-negative bacterial strains. The results show that quinazoline derivatives containing thiazole ring 2a and 2b exhibit good antibacterial activity amongst the compounds under investigation. [ABSTRACT FROM AUTHOR]

The synthesis of a series of 4-(7,7-dimethyl-4-[4-{N-aroyl/(het)aroyl/ benzyl}1-piperazinyl]-5,6,7,8- tetrahydroquinazolin-2-yl)morpholine derivatives has been described. The antiviral activity of these compounds against avian paramyxovirus (APMV-1), which is a Newcastle disease virus has also been screened. [ABSTRACT FROM AUTHOR]