1. Concise Synthesis of Both Enantiomers of Pilocarpine.
- Author
-
Schmidt T, Heise N, Merzweiler K, Deigner HP, Al-Harrasi A, and Csuk R
- Subjects
- 4-Butyrolactone chemical synthesis, Amides chemistry, Carboxylic Acids chemistry, Esterification, Hydrogenation, Hydrolysis, Pilocarpine chemistry, Stereoisomerism, 4-Butyrolactone analogs & derivatives, Furans chemistry, Pilocarpine chemical synthesis
- Abstract
Furan-2-carboxylic acid was used as a starting material for the synthesis of dehydro-homopilopic acid. Esterification, hydrogenation and enzymatic hydrolysis followed by the reduction of Weinreb amides and a single-step attachment of a 1-methyl-imidazole residue allowed for the concise synthesis of both enantiomers of pilocarpine.
- Published
- 2021
- Full Text
- View/download PDF