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Start Over Author "Bony, Emilie" Topic phytosterols
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2. Awara (Astrocaryum vulgare M.) pulp oil: Chemical characterization, and anti-inflammatory properties in a mice model of endotoxic shock and a rat model of pulmonary inflammation

Author

Bony, Emilie, Boudard, Frédéric, Brat, Pierre, Dussossoy, Emilie, Portet, Karine, Poucheret, Patrick, Giaimis, Jean, and Michel, Alain

Subjects
*LUNG physiology, *INFLAMMATION prevention, *CAROTENOID analysis, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANIMAL experimentation, *ANTI-inflammatory agents, *BIOPHYSICS, *BRONCHOALVEOLAR lavage, *CYTOKINES, *FATTY acids, *FRUIT, *RESEARCH methodology, *MEDICINAL plants, *MICE, *VEGETABLE oils, *VITAMIN E, *PHYTOCHEMICALS, *PLANT extracts, *PHYTOSTEROLS, *PHARMACODYNAMICS
Abstract

Abstract: Awara (Astrocaryum vulgare M.) is a palm fruit mainly used in nutrition. We analysed the pulp oil for fatty acid, tocopherol, carotenoid, and phytosterol and we evaluated whether this oil may attenuate inflammation in vivo. In an endotoxic shock model, awara pulp oil treatment decreased pro-inflammatory cytokines and increased anti-inflammatory cytokines. In a pulmonary inflammation model, awara pulp oil treatment reduced eosinophil and lymphocyte numbers recovered into the broncho-alveolar lavages. These results suggest that awara pulp oil administration can efficiently counteract an acute and chronic inflammatory response in vivo that is probably mediated by fatty acids and minor compounds. [Copyright &y& Elsevier]

Published
2012
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