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Tests the hypothesis that blockage of the endothelin-A (ETA)-receptor can reverse as well as prevent the increase in mean pulmonary artery pressure, right ventricle-to-left ventricle plus septum ratio. Study protocol; Cardiovascular effects of BQ-123 infusion on chronic hypoxia-induced pulmonary hypertension in rats; Mean systemic arterial pressure.

Tests the hypothesis that increased endothelin-1 (ET-1) produced in lung, can account for hypoxia-induced pulmonary hypertension via a paracrine effect on ETA receptors in the lung. Effects of the intravenous infusion of the ETA receptor antagonist BQ-a23 into rats; Attenuation of the hypoxic response.

Assesses the effect of garlic on pulmonary pressures in rats subjected to alveolar hypoxia and on vasoconstriction in isolated pulmonary arterial rings. Literature on garlic or allium sativum; Methodology of the study; Findings.