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We designed and fabricated a telecentric f-theta imaging lens (TFL) to improve the imaging performance of spectral domain optical coherence tomography (SD-OCT). By tailoring the field curvature aberration of the TFL, the flattened focal surface was well matched to the detector plane. Simulation results showed that the spot in the focal plane fitted well within a single pixel and the modulation transfer function at high spatial frequencies showed higher values compared with those of an achromatic doublet imaging lens, which are commonly used in SD-OCT spectrometers. The spectrometer using the TFL had an axial resolution of 7.8 μm, which was similar to the theoretical value of 6.2 μm. The spectrometer was constructed so that the achromatic doublet lens was replaced by the TFL. As a result, the SD-OCT imaging depth was improved by 13% (1.85 mm) on a 10 dB basis in the roll-off curve and showed better sensitivity at the same depth. The SD-OCT images of a multi-layered tape and a human palm proved that the TFL was able to achieve deeper imaging depth and better contrast. This feature was seen very clearly in the depth profile of the image. SD-OCT imaging performance can be improved simply by changing the spectrometer’s imaging lens. By optimizing the imaging lens, deeper SD-OCT imaging can be achieved with improved sensitivity.

Understanding the residual tattoo ink in skin after laser treatment is often critical for achieving good clinical outcomes. The current study aims to investigate the feasibility of a light-emitting diode (LED)-assisted CMOS camera to estimate the relative variations in tattoo contrast after the laser treatment. Asian mice were tattooed using two color inks (black and red). The LED illumination was a separate process from the laser tattoo treatment. Images of the ink tattoos in skin were acquired under the irradiation of three different LED colors (red, green, and blue) for pre- and post-treatment. The degree of contrast variation due to the treatment was calculated and compared with the residual tattoo distribution in the skin. The black tattoo demonstrated that the contrast consistently decreased after the laser treatment for all LED colors. However, the red tattoo showed that the red LED yielded an insignificant contrast whereas the green and blue LEDs induced a 30% (p < 0.001) and 26% (p < 0.01) contrast reduction between the treatment conditions, respectively. The proposed LED-assisted CMOS camera can estimate the relative variations in the image contrast before and after the laser tattoo treatment.