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Summary The ability to probe the membrane potential of multiple genetically defined neurons simultaneously would have a profound impact on neuroscience research. Genetically encoded voltage indicators are a promising tool for this purpose, and recent developments have achieved a high signal-to-noise ratio in vivo with 1-photon fluorescence imaging. However, these recordings exhibit several sources of noise and signal extraction remains a challenge. We present an improved signal extraction pipeline, spike-guided penalized matrix decomposition-nonnegative matrix factorization (SGPMD-NMF), which resolves supra- and subthreshold voltages in vivo. The method incorporates biophysical and optical constraints. We validate the pipeline with simultaneous patch-clamp and optical recordings from mouse layer 1 in vivo and with simulated and composite datasets with realistic noise. We demonstrate applications to mouse hippocampus expressing paQuasAr3-s or SomArchon1, mouse cortex expressing SomArchon1 or Voltron, and zebrafish spines expressing zArchon1.

We have fabricated and studied a system of two tunable and coupled nonlinear superconducting resonators. The nonlinearity is introduced by galvanically coupled dc superconducting quantum interference devices. We simulate the system response by means of a circuit model, which includes an additional signal path introduced by the electromagnetic environment. Furthermore, we present two methods allowing us to experimentally determine the nonlinearity. First, we fit the measured frequency and flux dependence of the transmission data to simulations based on the equivalent circuit model. Second, we fit the power dependence of the transmission data to a model that is predicted by the nonlinear equation of motion describing the system. Our results show that we are able to tune the nonlinearity of the resonators by almost two orders of magnitude via an external coil and two on-chip antennas. The studied system represents a basic building block for larger systems, allowing for quantum simulations of bosonic many-body systems with a larger number of lattice sites.

The Electron Loss and Fields Investigation with a Spatio-Temporal Ambiguity-Resolving option (ELFIN-STAR, or simply: ELFIN) mission comprises two identical 3-Unit (3U) CubeSats on a polar (~93deg inclination), nearly circular, low-Earth (~450 km altitude) orbit. Launched on September 15, 2018, ELFIN is expected to have a >2.5 year lifetime. Its primary science objective is to resolve the mechanism of storm-time relativistic electron precipitation, for which electromagnetic ion cyclotron (EMIC) waves are a prime candidate. From its ionospheric vantage point, ELFIN uses its unique pitch-angle-resolving capability to determine whether measured relativistic electron pitch-angle and energy spectra within the loss cone bear the characteristic signatures of scattering by EMIC waves or whether such scattering may be due to other processes. Pairing identical ELFIN satellites with slowly-variable along-track separation allows disambiguation of spatial and temporal evolution of the precipitation over minutes-to-tens-of-minutes timescales, faster than the orbit period of a single low-altitude satellite (~90min). Each satellite carries an energetic particle detector for electrons (EPDE) that measures 50keV to 5MeV electrons with deltaE/E, Submitted to Space Science Reviews April 2020. 51 pages, 7 tables, 21 figures

The ability to probe the membrane potential of multiple genetically defined neurons simultaneously would have a profound impact on neuroscience research. Genetically encoded voltage indicators are a promising tool for this purpose, and recent developments have achieved high signal to noise ratio in vivo with 1-photon fluorescence imaging. However, these recordings exhibit several sources of noise that present analysis challenges, namely light scattering, out-of-focus sources, motion, and blood flow. We present a novel signal extraction methodology, Spike-Guided Penalized Matrix Decomposition-Nonnegative Matrix Factorization (SGPMD-NMF), which resolves supra- and sub-threshold voltages with high fidelity, even in the presence of correlated noise. The method incorporates biophysical constraints (shared soma profiles for spiking and subthreshold dynamics) and optical constraints (smoother spatial profiles from defocused vs. in-focus sources) to cleave signal from background. We validated the pipeline using simulated and composite datasets with realistic noise properties. We demonstrate applications to mouse hippocampus expressing paQuasAr3-s or SomArchon, mouse cortex expressing SomArchon or Voltron, and zebrafish spine expressing zArchon1.

The stability of neural dynamics arises through a tight coupling of excitatory (E) and inhibitory (I) signals. Genetically encoded voltage indicators (GEVIs) can report both spikes and subthreshold dynamics in vivo, but voltage only reveals the combined effects of E and I synaptic inputs, not their separate contributions individually. Here we combine optical recording of membrane voltage with simultaneous optogenetic manipulation to probe E and I individually in barrel cortex Layer 1 (L1) neurons in awake mice. Our studies reveal how the L1 microcircuit integrates thalamocortical excitation, lateral inhibition and top-down neuromodulatory inputs. We develop a simple computational model of the L1 microcircuit which captures the main features of our data. Together, these results suggest a model for computation in L1 interneurons consistent with their hypothesized role in attentional gating of the underlying cortex. Our results demonstrate that all-optical electrophysiology can reveal basic principles of neural circuit function in vivo.One Sentence SummaryAll-optical electrophysiology revealed the function in awake mice of an inhibitory microcircuit in barrel cortex Layer 1.

The concept of parity describes the inversion symmetry of a system and is of fundamental relevance in the standard model, quantum information processing, and field theory. In quantum electrodynamics, parity is conserved and large field gradients are required to engineer the parity of the light-matter interaction operator. In this work, we engineer a potassium-like artificial atom represented by a specifically designed superconducting flux qubit. We control the wave function parity of the artificial atom with an effective orbital momentum provided by a resonator. By irradiating the artificial atom with spatially shaped microwave fields, we select the interaction parity in situ. In this way, we observe dipole and quadrupole selection rules for single state transitions and induce transparency via longitudinal coupling. Our work advances the design of tunable artificial multilevel atoms to a new level, which is particularly promising with respect to quantum chemistry simulations with near-term superconducting circuits., Comment: Published manuscript (6 pages, 3 figures) plus supplemental materials (8 pages, 2 figures)

Two-mode squeezing is a fascinating example of quantum entanglement manifested in cross-correlations of non-commuting observables between two subsystems. At the same time, these subsystems themselves may contain no quantum signatures in their self-correlations. These properties make two-mode squeezed (TMS) states an ideal resource for applications in quantum communication. Here, we generate propagating microwave TMS states by a beam splitter distributing single mode squeezing emitted from distinct Josephson parametric amplifiers along two output paths. We experimentally study the fundamental dephasing process of quantum cross-correlations in continuous-variable propagating TMS microwave states and accurately describe it with a theory model. In this way, we gain the insight into finite-time entanglement limits and predict high fidelities for benchmark quantum communication protocols such as remote state preparation and quantum teleportation. We acknowledge support by the German Research Foundation through FE 1564/1-1, Spanish MINECO/FEDER FIS2015-69983-P, UPV/EHU PhD grant, Basque Government Grant IT986-16, European Project AQuS (Project No. 640800), Elite Network of Bavaria through the program ExQM, the projects JST ERATO (Grant No. JPMJER1601) and JSPS KAKENHI (Grant No. 26220601 and Grant No. 15K17731). E.S. acknowledges support from a TUM August-Wilhelm Scheer Visiting Professorship and hospitality of Walther-Meissner-Institut and TUM Institute for Advanced Study. We would like to thank K. Kusuyama for assistance with part of the JPA fabrication.

Superconducting 3D microwave cavities offer state-of-the-art coherence times and a well controlled environment for superconducting qubits. In order to realize at the same time fast readout and long-lived quantum information storage, one can couple the qubit both to a low-quality readout and a high-quality storage cavity. However, such systems are bulky compared to their less coherent 2D counterparts. A more compact and scalable approach is achieved by making use of the multimode structure of a 3D cavity. In our work, we investigate such a device where a transmon qubit is capacitively coupled to two modes of a single 3D cavity. The external coupling is engineered so that the memory mode has an about 100 times larger quality factor than the readout mode. Using an all-microwave second-order protocol, we realize a lifetime enhancement of the stored state over the qubit lifetime by a factor of $6$ with a fidelity of approximately $80\%$ determined via quantum process tomography. We also find that this enhancement is not limited by fundamental constraints., 5 pages, 4 figures

For quantum information processing with superconducting circuits, efficient amplification of weak microwave signals is often required. For this purpose, Josephson parametric amplifiers (JPAs) are commonly used, due to their quantum-limited noise performance. The authors show that flux-driven JPAs exhibit hysteresis, even for negligible screening parameters, and that their amplification properties depend strongly on the resonator characteristics. These phenomena are important for a full understanding of the magnetic field response and parametric amplification in JPAs, and thus their application.

In experiments with superconducting quantum circuits, characterizing the photon statistics of propagating microwave fields is a fundamental task. We quantify the $n^{2}\,{+}\,n$ photon number variance of thermal microwave photons emitted from a black-body radiator for mean photon numbers $0.05\,{\lesssim}\,n\,{\lesssim}\,1.5$. We probe the fields using either correlation measurements or a transmon qubit coupled to a microwave resonator. Our experiments provide a precise quantitative characterization of weak microwave states and information on the noise emitted by a Josephson parametric amplifier., Comment: containing supplemental material

Displacement of propagating quantum states of light is a fundamental operation for quantum communication. It enables fundamental studies on macroscopic quantum coherence and plays an important role in quantum teleportation protocols with continuous variables. In our experiments, we have successfully implemented this operation for propagating squeezed microwave states. We demonstrate that, even for strong displacement amplitudes, there is no degradation of the squeezing level in the reconstructed quantum states. Furthermore, we confirm that path entanglement generated by using displaced squeezed states remains constant over a wide range of the displacement power.

Under the terms of the Creative Commons Attribution License 3.0 (CC-BY).-- et al., We realize a device allowing for tunable and switchable coupling between two frequency-degenerate superconducting resonators mediated by an artificial atom. For the latter, we utilize a persistent current flux qubit. We characterize the tunable and switchable coupling in the frequency and time domains and find that the coupling between the relevant modes can be varied in a controlled way. Specifically, the coupling can be tuned by adjusting the flux through the qubit loop or by controlling the qubit population via a microwave drive. Our measurements allow us to find parameter regimes for optimal coupler performance and quantify the tunability range., This work is supported by the German Research Foundation through SFB 631, Spanish MINECO FIS2012-36673-C03-02; UPV/EHU UFI 11/55; Basque Government IT472-10; CCQED, PROMISCE, and SCALEQIT EU projects. B.P. acknowledges support from the STC Center for Integrated Quantum Materials, NSF Grant No. DMR-1231319.

Under the terms of the Creative Commons Attribution license.-- et al., We report on ultrastrong coupling between a superconducting flux qubit and a resonant mode of a system comprised of two superconducting coplanar stripline resonators coupled galvanically to the qubit. With a coupling strength as high as 17.5% of the mode frequency, exceeding that of previous circuit quantum electrodynamics experiments, we observe a pronounced Bloch-Siegert shift. The spectroscopic response of our multimode system reveals a clear breakdown of the Jaynes-Cummings approximation. In contrast to earlier experiments, the high coupling strength is achieved without making use of an additional inductance provided by a Josephson junction. ©2016 American Physical Society, Thiswork is supported by the German Research Foundation through SFB 631 and FE 1564/1-1; Spanish MINECO FIS2012-36673-03-02, MAT2014-53432-C5-1-R, FIS2014- 55867-P and FIS2012-33022; CAM Research Network QUITEMAD+; UPV/EHU UFI 11/55, UPV/EHU PhD Grant, and Basque Government IT472-10; the Fondo Nacional de Desarrollo Cientifico y Tecnológico (FONDECYT, Chile) under Grant 1150653; the EU projects CCQED, PROMISCE, and SCALEQIT. We further acknowledge GEFENOL.

10 pags., 5 figs., We realize tunable coupling between two superconducting transmission line resonators. The coupling is mediated by a non-hysteretic rf SQUID acting as a flux-tunable mutual inductance between the resonators. We present a spectroscopic characterization of the device. In particular, we observe couplings g/2π ranging between –320 MHz and 37 MHz. In the case of g 0, the microwave power cross transmission between the two resonators is reduced by almost four orders of magnitude as compared to the case where the coupling is switched on., The authors acknowledge support from the German Research Foundation through SFB 631 and FE 1564/1-1; the EU projects CCQED, PROMISCE and SCALEQIT; the doctorate program ExQM of the Elite Network of Bavaria; the Spanish MINECO projects FIS2012-33022, FIS2012-36673-C03-02, and FIS2015-69983-P; the CAM Research Network QUITEMAD+; the Basque Government IT472-10 and UPV/EHU UFI 11/55.

Thermal microwave states are omnipresent noise sources in superconducting quantum circuits covering all relevant frequency regimes. We use them as a probe to identify three second-order decoherence mechanisms of a superconducting transmon. First, we quantify the efficiency of a resonator filter in the dispersive Jaynes-Cummings regime and find evidence for parasitic loss channels. Second, we probe second-order noise in the low-frequency regime and demonstrate the expected $T^{3}$ temperature dependence of the qubit dephasing rate. Finally, we show that qubit parameter fluctuations due to two-level states are enhanced under the influence of thermal microwave states. In particular, we experimentally confirm the $T^{2}$-dependence of the fluctuation spectrum expected for noninteracting two-level states., Comment: 13 pages, 10 figures