24 results on '"Physical Sciences"'
Search Results
2. Daily calving frequency and preterm calving is not associated with lunar cycle but preterm calving is associated with weather conditions in Japanese Black cows.
- Author
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Sasaki, Yosuke, Kitai, Narumi, Uematsu, Mizuho, Kitahara, Go, and Osawa, Takeshi
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LUNAR phases , *ATMOSPHERIC pressure , *COWS , *HUMIDITY , *SOLAR radiation , *WEATHER , *SENDAI Earthquake, Japan, 2011 - Abstract
Several external factors including lunar cycle and weather conditions might be associated with calving conditions. Our objective here was to determine the effects of lunar cycle and weather conditions on calving frequency and the occurrence of preterm calving in Japanese Black cows. Calving records were obtained from 905 farms in Miyazaki Prefecture, Japan. Data were collected from 41,116 calvings. We conducted two studies: Study 1 investigated the effects of lunar cycle and weather conditions on daily calving frequency (DCF) with the observational unit of each day and Study 2 investigated those effects on the occurrence of preterm calving with the observational unit for each calving. Preterm calving was defined by whether or not a cow calving before 280 days of gestation, lower 10th percentile of gestation length of the collected data, and by whether or not a cow calving before 289 days of gestation, median of the gestation length. For Study 1, lunar cycle was not associated with DCF in all cows, in only primiparous cows and in only multiparous cows. As well as lunar cycle, weather conditions such as temperature, diurnal temperature variation, the temperature-humidity index, precipitation amount, barometric pressure, relative humidity and solar radiation, were also not associated with DCF. For Study 2, lunar cycle phases were not associated with the occurrence of preterm calving. However, preterm calving was associated with all of the weather conditions (P < 0.05) except for precipitation amounts and solar radiation. Temperature, the temperature-humidity index and relative humidity were positively associated with the occurrence of preterm calving. In contrast, diurnal temperature variations and barometric pressure were negatively associated with the occurrence of preterm calving. In conclusion, the lunar cycle was not associated with DCF and preterm calving, but the weather conditions were associated with preterm calving. [ABSTRACT FROM AUTHOR]
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- 2019
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3. Cost-minimisation model of magnetic resonance-guided focussed ultrasound therapy compared to unilateral deep brain stimulation for essential tremor treatment in Japan.
- Author
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Igarashi, Ataru, Tanaka, Midori, Abe, Keiichi, Richard, Lance, Peirce, Vivian, and Yamada, Kazumichi
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BRAIN stimulation , *DEEP brain stimulation , *ESSENTIAL tremor , *THERAPEUTICS , *MEDICAL personnel , *MEDICAL care costs - Abstract
Objective: To investigate the cost differences between magnetic resonance-guided focussed ultrasound (MRgFUS) and unilateral deep brain stimulation (DBS) for the treatment of medication-refractory essential tremor (ET) in Japan using a cost-minimisation model. Methods: A cost-minimisation model estimated total costs for MRgFUS and unilateral DBS by summing the pre-procedure, procedure, and post-procedure costs over a 12-month time horizon, using data from published sources and expert clinical opinion. The model base case considered medical costs from fee-for-service tariffs. Scenario analyses investigated the use of Diagnosis Procedure Combination tariffs, a diagnosis-related group-based fixed-payment system, and the addition of healthcare professional labour costs healthcare professionals using tariffs from the Japanese Health Insurance Federation for Surgery. One-way sensitivity analyses altered costs associated with tremor recurrence after MRgFUS, the extraction rate following unilateral DBS, the length of hospitalisation for unilateral DBS and the procedure duration for MRgFUS. The impact of uncertainty in model parameters on the model results was further explored using probabilistic sensitivity analysis. Results: Compared to unilateral DBS, MRgFUS was cost saving in the base case and Diagnosis Procedure Combination cost scenario, with total savings of JPY400,380 and JPY414,691, respectively. The majority of savings were accrued at the procedural stage. Including labour costs further increased the cost differences between MRgFUS and unilateral DBS. Cost savings were maintained in each sensitivity analysis and the probabilistic sensitivity analysis, demonstrating that the model results are highly robust. Conclusions: In the Japanese healthcare setting, MRgFUS could be a cost saving option versus unilateral DBS for treating medication-refractory ET. The model results may even be conservative, as the cost of multiple follow-ups for unilateral DBS and treatment costs for adverse events associated with each procedure were not included. This model is also consistent with the results of other economic analyses of MRgFUS versus DBS in various settings worldwide. [ABSTRACT FROM AUTHOR]
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- 2019
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4. A brief home-based palliative care learning experience for medical students and resident doctors in Okinawa, Japan.
- Author
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Nagano, Hiroaki, Obara, Haruo, and Takayama, Yoshihiro
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MEDICAL students , *RESIDENTS (Medicine) , *PHYSICIAN-patient relations , *NURSING care facilities , *PHYSICIANS , *KOLB'S Experiential Learning theory , *PALLIATIVE treatment - Abstract
Background: The clinical component of medical education for students and resident doctors in Japan occurs almost entirely in the hospital setting. Because of this inpatient focus, graduate medical education clinical training often fails to expose physicians-in-training to the challenges that patients may face in the outpatient or home setting. This is a descriptive study in which we explore what participating students and resident doctors learned through our brief home-based teaching experience. Methods: From June 2016 to December 2017, attending physicians on the internal medicine service had medical students and resident doctors accompany them on home care visits. Participants were selected by convenience sampling based on their rotation availability. After the home visit and the interactive discussion, the participants were expected to prepare a reflective journal on their experience and learning. Thematic analysis was applied, and key themes were developed based on Kolb’s ELT (Experiential learning theory). Three months after completion of the experience, semi-structured interviews were individually conducted assessing participants’ self-perceived changes. Results: Thirty-two medical students(10) or residents(22)participated in a home visit. Thirty of these learners were able to complete a reflective journal. Using thematic analysis, we identified 2 domains and 6 key themes from the participants’ perceptions. Participants recognized the importance of patient-centered care, inter-professional collaboration of the home care team, and reconceptualized the meaning of medical practice and their professional identity as a doctor. Three month post-experience interviews were completed on 12 of the original 30 participants who completed the reflective journal. 2 domains and 6 key themes from the residents’ experiences and perceptions were generated. The participants reported an increased attention to the daily lives and social situations of their hospitalized patients, and an extension of their focus beyond the clinical medical treatment of the patient. Conclusion: The experience of a brief visit to a patient’s home is a novel educational approach that may potentially provide medical students and resident doctors with opportunities to learn about out-of-hospital, patient-centered, home-based medical care. [ABSTRACT FROM AUTHOR]
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- 2019
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5. Using GIS to simulate tsunami evacuation guidance signs for the hearing impaired.
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Horiike, Ryo, Nakai, Hisao, Itatani, Tomoya, Shirai, Fumie, and Konishi, Kaoru
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TSUNAMIS , *GEOGRAPHIC information systems , *SENDAI Earthquake, Japan, 2011 , *BUILDING evacuation - Abstract
The Nankai Trough in Japan has been identified as a geological feature that could cause extensive damage in the event of a major earthquake. In this study, we investigated the impact of effective guidance signs for hearing-impaired individuals requiring special care when escaping to a tsunami evacuation building (emergency evacuation location) using geographical information system (GIS) and viewshed analysis. We selected an area we considered would suffer severe damage following a major earthquake and tsunami; we identified difficulties in the provision of escape routes. Using GIS, we determined the time required for escape and tsunami arrival time if effective signs were installed; we undertook such analysis using the height data of buildings in the target area. With effectively installed guidance signs, the average required evacuation time was 36.88 minutes; without such signs (which is currently the case in the target area), the average time was 47.10 minutes: that would result in citizens getting caught by the tsunami. Installing effective guidance signs would allow hearing-impaired individuals to escape to an evacuation building before being hit by the tsunami. [ABSTRACT FROM AUTHOR]
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- 2019
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6. Physical constraints on sand crab burrows: Mechanical properties of wet sand explain the size and spatial distributions of burrows on beaches.
- Author
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Shinoda, Ayuko, Fujiwara, Shin-ichi, Niiya, Hirofumi, and Katsuragi, Hiroaki
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TUNNELS , *BEACHES , *CRABS , *SAND , *SHORELINES , *PHYSICAL sciences - Abstract
The diameter and vertical depth of sand crab tunnels in sandy beaches are usually restricted to a few centimeters scale and several tens of centimeters, respectively. We designed a study to determine what physical factors restrict tunnel diameter and predict the maximum attainable tunnel diameter and depth. We collected field data on the size and spatial distributions of ghost crab (Ocypode spp.) burrows on two sandy beaches (Kawage Beach in Tsu, Mie Prefecture, Japan and Sakieda Beach in Ishigaki, Okinawa Prefecture, Japan), where O. ceratophthalma dominants the ghost crab fauna. We measured burrow depths and distance from shoreline in concert with water content of sandy beaches. To explain our observed distributions of crab burrows in the field, we performed experiments in a lab microcosm, comprising a horizontal tunnel through wet sand. We measured the static stability of tunnel structures in relation to water content and two strengths computed from loading force exerted on the sand overlying the tunnels. By comparing field and experimental data, we found that crabs construct their burrows in appropriately wet zones (wet enough to provide sufficient cohesion of the sand grains in tunnel walls to prevent collapse) and that tunnel diameters and depths are sufficiently small to prevent deformation and collapse of their tunnels. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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7. Intra-athlete and inter-group comparisons: Running pace and step characteristics of elite athletes in the 400-m hurdles.
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Otsuka, Mitsuo and Isaka, Tadao
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LONG-distance running , *ELITE athletes , *STREAMING video & television , *RUNNING speed , *COACH-athlete relationships , *PHYSICAL sciences - Abstract
The aim of this study was to investigate the running pace and step characteristics among various competitive-level 400-m hurdlers through inter-group and intra-athlete comparisons. We analysed spatiotemporal data involving the split time, mean step length (SL) and mean step frequency (SF) for 13 male world-class and 14 male national-level 400-m hurdlers. We analysed 16.5 ± 3.9 races for each world-class hurdler and 19.8 ± 6.0 races for each national-level hurdler (the total number of analysed runs was 491) using publicly available television and internet broadcasts. Inter-group comparisons showed that both first- and latter-halves split times of the world-class hurdlers were significantly shorter than those of the national-level hurdlers. In the latter-half phase, no significant differences of SL and SF were observed between the world-class and national level hurdlers. Intra-athlete comparisons showed that no athletes favoured only first-half phase in terms of running speed in short finish times. In contrast, finish times of all hurdlers were sensitive to running speed in the latter-half phase. In the latter half of the race, 18 of the 27 hurdlers were identified as being SF reliant during speed enhancements; running speed of the other 9 hurdlers were also sensitive to high SF. In conclusions, important findings regarding high performance in inter-group comparisons do not always corresponded with those in intra-athlete comparisons. All athletes and coaches should first prioritize maintaining high running speeds in the latter half of 400-m hurdles rather than in the first half of the race. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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8. Time-series analysis of geographically specific monthly number of newly registered cases of active tuberculosis in Japan.
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Sumi, Ayako and Kobayashi, Nobumichi
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SENDAI Earthquake, Japan, 2011 , *TIME series analysis - Abstract
Background: Understanding seasonality of tuberculosis (TB) epidemics may lead to identify potentially modifiable risk factors. Studies conducted outside Japan have found seasonal variation among reported TB cases, with peaks in spring and summer and low prevalence in fall and winter. One hypothesis regarding spring or summer peaks in TB epidemics is that TB transmission likely increases in winter because of indoor crowding and poor ventilation, with development of primary TB among socially vulnerable people in spring and summer. Another plausible explanation is that vitamin D deficiency in winter depresses immunity, increasing the TB reactivation risk in these seasons. Previous studies suggest latitude-dependent factors, including reduced winter sunlight and its effect on vitamin D levels. Here, we investigated mechanisms of seasonality in TB epidemics in Japan, according to the effects of crowding and latitude. Methods: We used time-series analysis consisting of spectral analysis and least-squares method, to analyse geographically specific monthly number of newly registered cases of all forms of active TB in all 47 prefectures of Japan during 1998–2015. Results: In all power spectral densities for the 47 prefectures, spectral lines were observed at frequency positions corresponding to a 1-year cycle. The degree of this seasonality was associated with population density. We did not detect greater amplitude of seasonality at higher latitudes, suggesting that latitude-dependent factors, including reduced winter sunlight and its potential effect on vitamin D levels, do not contribute significantly to seasonality in Japan. Discussion and conclusion: In districts with high population density, measures are needed to address two specific types of active infection risk in adolescents and middle-aged adults: (i) public transport use, and (ii) irregular employment with no periodic medical examinations. To control active TB epidemics, investigating periodic structures in the temporal patterns of active TB in each district and each age group is important. [ABSTRACT FROM AUTHOR]
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- 2019
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9. Dynamic linear modeling of monthly electricity demand in Japan: Time variation of electricity conservation effect.
- Author
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Honjo, Keita, Shiraki, Hiroto, and Ashina, Shuichi
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ELECTRIC power consumption , *EARTHQUAKES , *SEASONAL temperature variations , *ELECTRIC rates , *DYNAMIC models - Abstract
After the severe nuclear disaster in Fukushima, which was triggered by the Great East Japan earthquake in March 2011, nuclear power plants in Japan were temporarily shut down for mandatory inspections. To prevent large-scale blackouts, the Japanese government requested companies and households to reduce electricity consumption in summer and winter. It is reported that the domestic electricity demand had a structural decrease because of the electricity conservation effect (ECE). However, quantitative analysis of the ECE is not sufficient, and especially time variation of the ECE remains unclear. Understanding the ECE is important because Japan’s NDC (nationally determined contribution) assumes the reduction of CO2 emissions through aggressive energy conservation. In this study, we develop a time series model of monthly electricity demand in Japan and estimate time variation of the ECE. Moreover, we evaluate the impact of electricity conservation on CO2 emissions from power plants. The dynamic linear model is used to separate the ECE from the effects of other irrelevant factors (e.g. air temperature, economic production, and electricity price). Our result clearly shows that consumers’ electricity conservation behavior after the earthquake was not temporary but became established as a habit. Between March 2011 and March 2016, the ECE on industrial electricity demand ranged from 3.9% to 5.4%, and the ECE on residential electricity demand ranged from 1.6% to 7.6%. The ECE on the total electricity demand was estimated at 3.2%–6.0%. We found a seasonal pattern that the residential ECE in summer is higher than that in winter. The emissions increase from the shutdown of nuclear power plants was mitigated by electricity conservation. The emissions reduction effect was estimated at 0.82 MtCO2–2.26 MtCO2 (−4.5% on average compared to the zero-ECE case). The time-varying ECE is necessary for predicting Japan’s electricity demand and CO2 emissions after the earthquake. [ABSTRACT FROM AUTHOR]
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- 2018
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10. Have the tsunami and nuclear accident following the Great East Japan Earthquake affected the local distribution of hospital physicians?
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Kashima, Saori, Inoue, Kazuo, and Matsumoto, Masatoshi
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SENDAI Earthquake, Japan, 2011 , *NUCLEAR accidents , *PHYSICIANS , *FUKUSHIMA Nuclear Accident, Fukushima, Japan, 2011 , *MEDICAL care - Abstract
Objective: The Great East Japan Earthquake occurred on 11 March 2011 near the northeast coast of the main island, ‘Honshu’, of Japan. It wreaked enormous damage in two main ways: a giant tsunami and an accident at the Fukushima Daiichi Nuclear Power Plant (FDNPP). This disaster may have affected the distribution of physicians in the region. Here, we evaluate the effect of the disaster on the distribution of hospital physicians in the three most severely affected prefectures (Iwate, Miyagi, and Fukushima). Methods: We obtained individual information about physicians from the Physician Census in 2010 (pre-disaster) and 2012 (post-disaster). We examined geographical distributions of physicians in two ways: (1) municipality-based analysis for demographic evaluation; and (2) hospital-based analysis for geographic evaluation. In each analysis, we calculated the rate of change in physician distributions between pre- and post-disaster years at various distances from the tsunami-affected coast, and from the restricted area due to the FDNPP accident. Results: The change in all, hospital, and clinic physicians were 0.2%, 0.7%, and −0.7%, respectively. In the municipality-based analysis, after taking account of the decreased population, physician numbers only decreased within the restricted area. In the hospital-based analysis, hospital physician numbers did not decrease at any distance from the tsunami-affected coast. In contrast, there was a 3.3% and 2.3% decrease in hospital physicians 0–25 km and 25–50 km from the restricted area surrounding the FDNPP, respectively. Additionally, decreases were larger and increases were smaller in areas close to the FDNPP than in areas further away. Conclusions: Our results suggest that the tsunami did not affect the distribution of physicians in the affected regions. However, the FDNPP accident changed physician distribution in areas close to the power plant. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Qualitative simulation of bathymetric changes due to reservoir sedimentation: A Japanese case study.
- Author
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Bilal, Ahmed, Dai, Wenhong, Larson, Magnus, Beebo, Qaid Naamo, and Xie, Qiancheng
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RESERVOIR sedimentation , *RIVERS , *SEDIMENTATION & deposition , *FORECASTING - Abstract
Sediment-dynamics modeling is a useful tool for estimating a dam’s lifespan and its cost–benefit analysis. Collecting real data for sediment-dynamics analysis from conventional field survey methods is both tedious and expensive. Therefore, for most rivers, the historical record of data is either missing or not very detailed. Available data and existing tools have much potential and may be used for qualitative prediction of future bathymetric change trend. This study shows that proxy approaches may be used to increase the spatiotemporal resolution of flow data, and hypothesize the river cross-sections and sediment data. Sediment-dynamics analysis of the reach of the Tenryu River upstream of Sakuma Dam in Japan was performed to predict its future bathymetric changes using a 1D numerical model (HEC-RAS). In this case study, only annually-averaged flow data and the river’s longitudinal bed profile at 5-year intervals were available. Therefore, the other required data, including river cross-section and geometry and sediment inflow grain sizes, had to be hypothesized or assimilated indirectly. The model yielded a good qualitative agreement, with an R2 (coefficient of determination) of 0.8 for the observed and simulated bed profiles. A predictive simulation demonstrated that the useful life of the dam would end after the year 2035 (±5 years), which is in conformity with initial detailed estimates. The study indicates that a sediment-dynamic analysis can be performed even with a limited amount of data. However, such studies may only assess the qualitative trends of sediment dynamics. [ABSTRACT FROM AUTHOR]
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- 2017
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12. Analysis of the complete genome sequence of Nocardia seriolae UTF1, the causative agent of fish nocardiosis: The first reference genome sequence of the fish pathogenic Nocardia species.
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Yasuike, Motoshige, Nishiki, Issei, Iwasaki, Yuki, Nakamura, Yoji, Fujiwara, Atushi, Shimahara, Yoshiko, Kamaishi, Takashi, Yoshida, Terutoyo, Nagai, Satoshi, Kobayashi, Takanori, and Katoh, Masaya
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NUCLEOTIDE sequence , *NOCARDIOSIS , *AQUACULTURE , *MICROBIAL virulence , *PATHOGENIC bacteria - Abstract
Nocardiosis caused by Nocardia seriolae is one of the major threats in the aquaculture of Seriola species (yellowtail; S. quinqueradiata, amberjack; S. dumerili and kingfish; S. lalandi) in Japan. Here, we report the complete nucleotide genome sequence of N. seriolae UTF1, isolated from a cultured yellowtail. The genome is a circular chromosome of 8,121,733 bp with a G+C content of 68.1% that encodes 7,697 predicted proteins. In the N. seriolae UTF1 predicted genes, we found orthologs of virulence factors of pathogenic mycobacteria and human clinical Nocardia isolates involved in host cell invasion, modulation of phagocyte function and survival inside the macrophages. The virulence factor candidates provide an essential basis for understanding their pathogenic mechanisms at the molecular level by the fish nocardiosis research community in future studies. We also found many potential antibiotic resistance genes on the N. seriolae UTF1 chromosome. Comparative analysis with the four existing complete genomes, N. farcinica IFM 10152, N. brasiliensis HUJEG-1 and N. cyriacigeorgica GUH-2 and N. nova SH22a, revealed that 2,745 orthologous genes were present in all five Nocardia genomes (core genes) and 1,982 genes were unique to N. seriolae UTF1. In particular, the N. seriolae UTF1 genome contains a greater number of mobile elements and genes of unknown function that comprise the differences in structure and gene content from the other Nocardia genomes. In addition, a lot of the N. seriolae UTF1-specific genes were assigned to the ABC transport system. Because of limited resources in ocean environments, these N. seriolae UTF1 specific ABC transporters might facilitate adaptation strategies essential for marine environment survival. Thus, the availability of the complete N. seriolae UTF1 genome sequence will provide a valuable resource for comparative genomic studies of N. seriolae isolates, as well as provide new insights into the ecological and functional diversity of the genus Nocardia. [ABSTRACT FROM AUTHOR]
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- 2017
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13. Dispersion of radiocesium-contaminated bottom sediment caused by heavy rainfall in Joso City, Japan.
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Inoue, Kazumasa, Arai, Moeko, and Fukushi, Masahiro
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RAINFALL , *DISASTERS , *FUKUSHIMA Nuclear Accident, Fukushima, Japan, 2011 , *STANDARD deviations , *PARTICLE size determination - Abstract
A large-scale heavy rainfall disaster occurred in Joso City, Japan, in September 2015, and one third of the city area (40 km2) was flooded by the Kinu River. Artificial radionuclides such as 134Cs and 137Cs were known to have accumulated in the river bottom sediment after their release in the 2011 Fukushima Dai-ichi Nuclear Power Plant accident. It was thought that these radionuclides might have been dispersed by the rainfall disaster. A car-borne survey of absorbed dose rate in air had been made by the authors in Joso City in August 2015. Then, the present study made a second car-borne survey in October 2015, to evaluate changes in the rate after the rainfall disaster. The absorbed dose rate in air and the standard deviation (range) measured in the flooded areas of Joso City after the disaster were 68 ± 9 nGy h-1 (39–98 nGy h-1), which was 10% higher than the rate before it. Additionally, higher dose rates (> 60 nGy h-1) were observed for the flooded areas after the disaster; furthermore, up to 886 Bq kg-1 of activity concentration from 134Cs and 137Cs was observed in these flooded areas, and this was 11 times higher than the activity concentration before the disaster. These results suggested the dispersion of artificial radionuclides accumulated in the bottom sediment of the Kinu River after the Fukushima Daiichi Nuclear Power Plant accident occurred by the heavy rainfall disaster. [ABSTRACT FROM AUTHOR]
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- 2017
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14. Relationship between pre-anesthetic and intra-anesthetic airway resistance in patients undergoing general anesthesia: A prospective observational study.
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Ikeda, Takamitsu, Uchida, Kanji, Yamauchi, Yasuhiro, Nagase, Takahide, Oba, Koji, and Yamada, Yoshitsugu
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RESPIRATORY obstructions , *GENERAL anesthesia , *SPIROMETRY , *ANESTHETICS , *AIRWAY (Anatomy) , *LONGITUDINAL method - Abstract
Surgery patients in Japan undergo routine spirometry testing prior to general anesthesia. The use of a flow sensor during general anesthesia has recently become common. However, it is not certain whether the information derived from flow-volume curves is being adequately used for mechanical ventilation management during general anesthesia. So far, there have been no attempts to calculate airway resistance using flow-volume curves. Therefore, we performed a prospective, observational study to investigate the relationship between pre-anesthetic and intra-anesthetic airway resistance in patients scheduled for surgery under general anesthesia. We calculated pre-anesthetic and intra-anesthetic airway resistance in each patient, based on the slopes of flow-volume curves obtained prior to and during general anesthesia. We also calculated endotracheal tube resistance to correct the intra-anesthetic airway resistance values calculated. A total of 526 patients were included in the study, and 98 patients had a forced expiratory volume in the first second/forced vital capacity ratio of < 70%. Pre-anesthetic airway resistance was significantly higher in patients with airflow obstruction than in those without airflow obstruction (p < 0.001), whereas no significant difference in intra-anesthetic airway resistance was found between patients with and without airflow obstruction during mechanical ventilation (p = 0.48). Pre-anesthetic and intra-anesthetic airway resistance values were closer to each other in patients without airflow obstruction, with a mean difference < 1.0 cmH2O L-1s-1, than in those with airflow obstruction, although these respiratory parameters were significantly different (p < 0.001). Intra-anesthetic airway resistance was not related to the FEV1/FVC ratio, regardless of the degree to which the FEV1/FVC ratio reflected pre-anesthetic airway resistance. As compared with patients with airflow obstruction, the mean difference between pre-anesthetic and intra-anesthetic airway resistance was small in patients without airflow obstruction. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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15. Crystal structure and structure-based mutagenesis of actin-specific ADP-ribosylating toxin CPILE-a as novel enterotoxin.
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Toniti, Waraphan, Yoshida, Toru, Tsurumura, Toshiharu, Irikura, Daisuke, Monma, Chie, Kamata, Yoichi, and Tsuge, Hideaki
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MUTAGENESIS , *FOOD poisoning , *ADP-ribosylation , *EPIDEMIOLOGY , *ENTEROTOXINS - Abstract
Unusual outbreaks of food poisoning in Japan were reported in which Clostridium perfringens was strongly suspected to be the cause based on epidemiological information and fingerprinting of isolates. The isolated strains lack the typical C. perfringens enterotoxin (CPE) but secrete a new enterotoxin consisting of two components: C. perfringens iota-like enterotoxin-a (CPILE-a), which acts as an enzymatic ADP-ribosyltransferase, and CPILE-b, a membrane binding component. Here we present the crystal structures of apo-CPILE-a, NAD+-CPILE-a and NADH-CPILE-a. Though CPILE-a structure has high similarity with known iota toxin-a (Ia) with NAD+, it possesses two extra-long protruding loops from G262-S269 and E402-K408 that are distinct from Ia. Based on the Ia–actin complex structure, we focused on actin-binding interface regions (I-V) including two protruding loops (PT) and examined how mutations in these regions affect the ADP-ribosylation activity of CPILE-a. Though some site-directed mutagenesis studies have already been conducted on the actin binding site of Ia, in the present study, mutagenesis studies were conducted against both α- and β/γ-actin in CPILE-a and Ia. Interestingly, CPILE-a ADP-ribosylates both α- and β/γ-actin, but its sensitivity towards β/γ-actin is 36% compared with α-actin. Our results contrast to that only C2-I ADP-ribosylates β/γ-actin. We also showed that PT-I and two convex-concave interactions in CPILE-a are important for actin binding. The current study is the first detailed analysis of site-directed mutagenesis in the actin binding region of Ia and CPILE-a against both α- and β/γ-actin. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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16. Characteristics of Physician Outflow from Disaster Areas following the Great East Japan Earthquake.
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Kashima, Saori, Inoue, Kazuo, and Matsumoto, Masatoshi
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EARTHQUAKES , *PHYSICIANS , *DEMOGRAPHIC change , *POWER plants , *PUBLIC health - Abstract
Objective: The shortage of physicians after a major disaster is a crucial issue. We aimed to evaluate the characteristics of physicians who left affected areas following the accident at Fukushima Daiichi Nuclear Power Plant caused by the Great East Japan Earthquake on March 11, 2011. Methods: Using data from a physician census conducted in 2010 (pre-disaster) and 2012 (post-disaster), we evaluated changes in the number of physicians in affected areas. We then calculated the odds ratios and 95% confidence intervals using a logistic regression model to evaluate the association between physician characteristics and outflow. We also conducted stratified analyses based on physician characteristics. Results: The number of physicians decreased in Fukushima Prefecture (–5.3%) and increased in Miyagi Prefecture (2.8%). The decrease in Fukushima and increase in Miyagi were evident even after taking the prefecture’s population change into account (change in physician to population ratios: –1.9% and 3.2%, respectively). Compared with physicians who lived in areas >100 km from the nuclear power plant, physicians living 20–50 km and 50–100 km were, respectively, 3.9 times (95% confidence interval, 2.6–5.7) and 2.6 times (95% confidence interval, 1.7–3.8) more likely to migrate to distant areas. In the stratified analysis, younger physicians and those earlier in their careers had higher odds ratios for outflow than other physicians (P for interaction = 0.02 and <0.01, respectively). Conclusions: The risk of outflow was greater among younger and early-career physicians in areas around the power plant. Political support may be necessary to recruit and retain such physicians, who will be responsible for future community health in the disaster area. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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17. Recovery of Coastal Fauna after the 2011 Tsunami in Japan as Determined by Bimonthly Underwater Visual Censuses Conducted over Five Years.
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Masuda, Reiji, Hatakeyama, Makoto, Yokoyama, Katsuhide, and Tanaka, Masaru
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TSUNAMIS , *UNDERWATER navigation , *DISASTERS , *COASTAL animals , *SPECIES diversity - Abstract
Massive tsunamis induce catastrophic disturbance in marine ecosystems, yet they can provide unique opportunities to observe the process of regeneration. Here, we report the recovery of fauna after the 2011 tsunami in northeast Japan based on underwater visual censuses performed every two months over five years. Both total fish abundance and species richness increased from the first to the second year after the tsunami followed by stabilization in the following years. Short-lived fish, such as the banded goby Pterogobius elapoides, were relatively abundant in the first two years, whereas long-lived species, such as the black rockfish Sebastes cheni, increased in the latter half of the survey period. Tropical fish species were recorded only in the second and third years after the tsunami. The body size of long-lived fish increased during the survey period resulting in a gradual increase of total fish biomass. The recovery of fish assemblages was slow at one site located in the inner bay, where the impact of the tsunami was the strongest. Apart from fish, blooms of the moon jellyfish Aurelia sp. occurred only in the first two years after the tsunami, whereas the abundances of sea cucumber Apostichopus japonicus and abalone Haliotis discus hannai increased after the second year. Although we lack quantitative data prior to the tsunami, we conclude that it takes approximately three years for coastal reef fish assemblages to recover from a heavy disturbance such as a tsunami and that the recovery is dependent on species-specific life span and habitat. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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18. Structural Changes in Molluscan Community over a 15-Year Period before and after the 2011 Great East Japan Earthquake and Subsequent Tsunami around Matsushima Bay, Miyagi Prefecture, Northeastern Japan.
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Sato, Shin’ichi and Chiba, Tomoki
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EARTHQUAKES , *TSUNAMIS , *EARTH sciences , *MYA arenaria , *POPULATION biology - Abstract
We examined structural changes in the molluscan community for ten years (2001–2010) before and five years (2011–2015) after the 2011 Great East Japan Earthquake and subsequent tsunami around Matsushima Bay, Miyagi Prefecture, northeastern Japan. Before the earthquake and tsunami, Ruditapes philippinarum, Macoma incongrua, Pillucina pisidium, and Batillaria cumingii were dominant, and an alien predator Laguncula pulchella appeared in 2002 and increased in number. After the tsunami, R. philippinarum and M. incongrua populations quickly recovered in 2012, but P. pisidium and B. cumingii populations did not recover until 2015. By contrast, Musculista senhousia, Mya arenaria, Retusa sp., and Solen strictus were found in low densities before the tsunami, but they rapidly increased in abundance/number over five years after the tsunami. These results suggest that the molluscan community on the Tona Coast was drastically changed by the earthquake and tsunami, and some species mainly inhabiting the intertidal—subtidal zone may have increased in number because of land subsidence. We also emphasize that the seawall delayed recovery of the intertidal community after the earthquake and tsunami. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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19. Hospital Staff Shortage after the 2011 Triple Disaster in Fukushima, Japan-An Earthquake, Tsunamis, and Nuclear Power Plant Accident: A Case of the Soso District.
- Author
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Ochi, Sae, Tsubokura, Masaharu, Kato, Shigeaki, Iwamoto, Shuichi, Ogata, Shinichi, Morita, Tomohiro, Hori, Arinobu, Oikawa, Tomoyoshi, Kikuchi, Antoku, Watanabe, Zenjiro, Kanazawa, Yukio, Kumakawa, Hiromi, Kuma, Yoshinobu, Kumakura, Tetsuo, Inomata, Yoshimitsu, Kami, Masahiro, Shineha, Ryuzaburo, and Saito, Yasutoshi
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NUCLEAR power plant accidents , *FUKUSHIMA Nuclear Accident, Fukushima, Japan, 2011 , *EARTHQUAKES , *TSUNAMIS , *PHYSIOLOGICAL effects of radiation , *HOSPITAL personnel - Abstract
Introduction: In 2011, Fukushima was struck by a triple disaster: an earthquake, tsunamis, and a nuclear accident. In the aftermath, there was much fear among hospital staff members about radiation exposure and many staff members failed to report to work. Objectives: One objective is to measure this shortage in hospital staff and another is to compare the difference in recovery by hospital types and by categories of hospital staff. Design: The monthly records of the number of staff members from May 2011 to September 2012 were extracted anonymously from the records of 7 local hospitals in the Soso district in Fukushima. Change in the number of staff was analyzed. Results: Staff shortages at hospitals reached a maximum within one month after the disaster (47% reported to work). The shortage of clerks was the most severe (38% reported to work), followed by nurses (48% reported to work). The shortages remained even 18 months after the disaster. Conclusion: After a disaster in which the damage to hospital functions surpasses the structural damage, massive support of human resources in the acute phase and a smaller volume of support in the mid-term phase appear to be required, particularly for non-medical staff. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
20. Statistical Analysis of the Effectiveness of Seawalls and Coastal Forests in Mitigating Tsunami Impacts in Iwate and Miyagi Prefectures.
- Author
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Nateghi, Roshanak, Bricker, Jeremy D., Guikema, Seth D., and Bessho, Akane
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SEA-walls , *COASTAL forest ecology , *TSUNAMIS , *GEOMORPHOLOGY , *ENVIRONMENTAL impact analysis - Abstract
The Pacific coast of the Tohoku region of Japan experiences repeated tsunamis, with the most recent events having occurred in 1896, 1933, 1960, and 2011. These events have caused large loss of life and damage throughout the coastal region. There is uncertainty about the degree to which seawalls reduce deaths and building damage during tsunamis in Japan. On the one hand they provide physical protection against tsunamis as long as they are not overtopped and do not fail. On the other hand, the presence of a seawall may induce a false sense of security, encouraging additional development behind the seawall and reducing evacuation rates during an event. We analyze municipality-level and sub-municipality-level data on the impacts of the 1896, 1933, 1960, and 2011 tsunamis, finding that seawalls larger than 5 m in height generally have served a protective role in these past events, reducing both death rates and the damage rates of residential buildings. However, seawalls smaller than 5 m in height appear to have encouraged development in vulnerable areas and exacerbated damage. We also find that the extent of flooding is a critical factor in estimating both death rates and building damage rates, suggesting that additional measures, such as multiple lines of defense and elevating topography, may have significant benefits in reducing the impacts of tsunamis. Moreover, the area of coastal forests was found to be inversely related to death and destruction rates, indicating that forests either mitigated the impacts of these tsunamis, or displaced development that would otherwise have been damaged. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
21. Current Measures on Radioactive Contamination in Japan: A Policy Situation Analysis.
- Author
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Gilmour, Stuart, Miyagawa, Shoji, Kasuga, Fumiko, and Shibuya, Kenji
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RADIOACTIVE contamination of food , *SENDAI Earthquake, Japan, 2011 , *FUKUSHIMA Nuclear Accident, Fukushima, Japan, 2011 , *FOOD safety policy , *FOOD contamination - Abstract
Background: The Great East Japan Earthquake on 11th March 2011 and the subsequent Fukushima Dai-ichi nuclear power plant disaster caused radioactive contamination in the surrounding environment. In the immediate aftermath of the accident the Government of Japan placed strict measures on radio-contamination of food, and enhanced radio-contamination monitoring activities. Japan is a pilot country in the WHO Foodborne Disease Burden Epidemiology Reference Group (FERG), and through this initiative has an opportunity to report on policy affecting chemicals and toxins in the food distribution network. Nuclear accidents are extremely rare, and a policy situation analysis of the Japanese government’s response to the Fukushima Dai-ichi nuclear accident is a responsibility of Japanese scientists. This study aims to assess Japan government policies to reduce radio-contamination risk and to identify strategies to strengthen food policies to ensure the best possible response to possible future radiation accidents. Methods and Findings: We conducted a hand search of all publicly available policy documents issued by the Cabinet Office, the Food Safety Commission, the Ministry of Health, Labor and Welfare (MHLW), the Ministry of Agriculture, Forestry and Fishery (MAFF) and prefectural governments concerning food safety standards and changes to radiation and contamination standards since March 11th, 2011. We extracted information on food shipment and sales restrictions, allowable radio-contamination limits, monitoring activities and monitoring results. The standard for allowable radioactive cesium (Cs-134 and Cs-137) of 100 Bq/Kg in general food, 50 Bq/Kg in infant formula and all milk products, and 10 Bq/Kg in drinking water was enforced from April 2012 under the Food Sanitation Law, although a provisional standard on radio-contamination had been applied since the nuclear accident. Restrictions on the commercial sale and distribution of specific meat, vegetable and fish products were released for areas at risk of radioactive contamination. Monitoring of radioactive materials in food products in the prefectures has been mainly conducted before shipment to restrict the distribution of radio-contaminated foods. Between March 2011 and March 2012, 133,832 tests of non-commercial and commercial products were conducted, and 1,204 tests (0.9%) were found to violate the provisional standards. Since April 2012, 278,275 tests were conducted, and 2,372 tests (0.9%) were found to violate the revised standards. MHLW assessment of representative market baskets of foodstuffs at 15 locations throughout Japan between February and March 2014 found very low estimated dietary intake of radioactive cesium (0.0007–0.019 mSv/year), as did assessments of the contents of an average day’s food. Monitoring of fisheries products in coastal areas affected by the nuclear accident found very limited and declining radio-contamination of live fish outside of Fukushima prefecture. Fisheries monitoring is of limited geographical scope and covers only certain fishes. Conclusions: Area-specific bans on production and distribution have been effective in preventing radioactive contamination in the Japanese food market. Currently there is no major concern about radioactive cesium concentrations in retail foodstuffs in Japan, and very low levels of contamination at the production and wholesale stage. However, because the residue limits and food safety policies were revised on an ad hoc, emergency basis after the nuclear accident, the monitoring procedure needs to be reviewed based on objective and scientifically rational criteria. A transparent and objective scientific framework is needed for prioritizing foodstuffs for inspection and revising Prefecture-specific restrictions. Monitoring of fishes and other seafood products in the wild should be regularized and the information made more publicly accessible, and monitoring activities expanded to identify foodstuffs that are no longer a food safety risk. Consultation with producers and consumers should be more formalized to ensure their concerns are incorporated into regular policy reviews in an appropriate and transparent manner. However, despite the limited available knowledge on best practice in food control and enforcement of provisional radio-contamination limits after the accident, current Japanese policy is sufficient to protect the Japanese public from major risk of radio-contamination from the commercial food market. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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22. Visible Light Image-Based Method for Sugar Content Classification of Citrus.
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Wang, Xuefeng, Wu, Chunyan, and Hirafuji, Masayuki
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SUGAR content of fruit , *CITRUS , *VISIBLE spectra , *IMAGE analysis , *STATISTICAL correlation - Abstract
Visible light imaging of citrus fruit from Mie Prefecture of Japan was performed to determine whether an algorithm could be developed to predict the sugar content. This nondestructive classification showed that the accurate segmentation of different images can be realized by a correlation analysis based on the threshold value of the coefficient of determination. There is an obvious correlation between the sugar content of citrus fruit and certain parameters of the color images. The selected image parameters were connected by addition algorithm. The sugar content of citrus fruit can be predicted by the dummy variable method. The results showed that the small but orange citrus fruits often have a high sugar content. The study shows that it is possible to predict the sugar content of citrus fruit and to perform a classification of the sugar content using light in the visible spectrum and without the need for an additional light source. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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23. J-PARC Project in Japan
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Nagamiya, Shoji
- Subjects
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PROTONS , *PHYSICAL sciences , *PHYSICS - Abstract
From Japanese fiscal year JFY2001 a new accelerator project to provide high-intensity proton beams proceeded into its construction phase. This project, called the J-PARC (Japan Proton Accelerator Research Complex), is promoted under the cooperation of two institutions, KEK and JAEA. We set a goal to achieve 1 MW proton beams at 3 GeV and 0.75 MW beams at 50 GeV. The project will be completed in JFY2008, with anticipated first beams in the late 2008. In this article I will describe the project itself and examples of Day-1 experiments, in particular, in the area of nuclear and particle physics. [Copyright &y& Elsevier]
- Published
- 2006
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24. J-PARC and the T2K experiment
- Author
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Hayato, Y.
- Subjects
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NUCLEAR physics , *PHYSICS , *PHYSICAL sciences - Abstract
Since 2001, the construction of a new high intensity accelerator complex was started in Japan. This facility is called the Japan Proton Accelerator Research Complex (J-PARC) and intended to provide high intense primary proton and various secondary beams. The 0.75MW 50GeV proton beam will be available for particle and nuclear physics. The Tokai to Kamioka long baseline neutrino oscillation experiment (T2K), which utilizes the 50GeV proton beam, has been proposed and approved in 2004. This experiment is expected to be started in 2009. A sensitive search of oscillation and a precision measurement of are the main objectives of the first stage of the T2K experiment. [Copyright &y& Elsevier]
- Published
- 2005
- Full Text
- View/download PDF
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