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Introduction: To evaluate the consequences of bronchopulmonary dysplasia (BPD) on academic outcomes and healthcare use in adolescents born very preterm. Methods: This cohort study included 15-year-old adolescents born very preterm (< 32 weeks) between 2011 and 2013, with and without BPD, and controls born full term. Data regarding academic performance, current medical follow-up, and family characteristics were collected. Multivariate logistic regression was used to quantify relationships between academic outcomes and BPD. Results: From the 1341 children included in the initial cohort, 985 adolescents were eligible and 351 included (55 preterms with a history of BPD, 249 without, and 47 controls). Among adolescents born very preterm, a history of BPD was associated with a higher risk to attend a school for children with special needs (p < 0.05) and to have repeated a grade (p = 0.01). It was also associated with an increased number of medical and paramedical consultations. A history of BPD was not associated with the parents’ employment status, family structure, or the presence of younger siblings. Conclusion: This study highlights that a history of BPD is associated with poorer academic outcomes and high healthcare use in adolescence. [ABSTRACT FROM AUTHOR]

High-Throughput Satellites (HTS) are a distinctive class of communication satellites that provide significantly more throughput per allocated bandwidth than traditional wide-beam communication satellites. They are the proverbial wave of creative disruption in the space industry and are poised to disrupt the communication market in significant ways. The objective of this work is to develop a decision-analytic framework for assessing the value of High-Throughput Satellites and to provide meaningful results of the value of such systems under realistic design, operational, and market conditions. We develop the cost and revenue models of HTS. To build the revenue model, we develop a hybrid data-driven and scenario-based load factor model that combines historical data based on financial records from current HTS operators with extrapolations based on best-, nominal-, and worst-case scenarios. We then integrate the cost and revenue models within a stochastic simulation environment and perform Monte-Carlo analysis of the net present value (NPV) of HTS. One important result is that a medium-sized HTS significantly outperforms a roughly equivalent traditional wide-beam satellite, even under the worst-case loading scenario. Another important result, here identified and quantified, is the tradeoff between the average revenue per user (ARPU) and average loading of the satellite and how it is mediated by the downlink speed provided to consumers. This result can be used in different ways, for example, by helping define the boundaries of what is competitively achievable in terms of ARPU and downlink speed offerings. The implications of these results are that they delineate the pathways to financial failure and the boundaries beyond which an HTS will be value-negative, or alternatively, the asymptotic minimum values for an HTS to be value-positive. [ABSTRACT FROM AUTHOR]

At higher latitudes, vertebrates exhibit a seasonal cycle of reproduction in response to changes in day-length, referred to as photoperiodism. Extended day-length induces thyroid-stimulating hormone in the pars tuberalis of the pituitary gland. This hormone triggers the local activation of thyroid hormone in the mediobasal hypothalamus and eventually induces gonadal development. In avian species, light information associated with day-length is detected through photoreceptors located in deep-brain regions. Within these regions, the expressions of multiple photoreceptive molecules, opsins, have been observed. However, even though the Japanese quail is an excellent model for photoperiodism because of its robust and significant seasonal responses in reproduction, a comprehensive understanding of photoreceptors in the quail brain remains undeveloped. In this study, we initially analyzed an action spectrum using photoperiodically induced expression of the beta subunit genes of thyroid-stimulating hormone in quail. Among seven wavelengths examined, we detected maximum sensitivity of the action spectrum at 500 nm. The low value for goodness of fit in the alignment with a template of retinal1-based photopigment, assuming a spectrum associated with a single opsin, proposed the possible involvement of multiple opsins rather than a single opsin. Analysis of gene expression in the septal region and hypothalamus, regions hypothesized to be photosensitive in quail, revealed mRNA expression of a mammal-like melanopsin in the infundibular nucleus within the mediobasal hypothalamus. However, no significant diurnal changes were observed for genes in the infundibular nucleus. Xenopus-like melanopsin, a further isoform of melanopsin in birds, was detected in neither the septal region nor the infundibular nucleus. These results suggest that the mammal-like melanopsin expressed in the infundibular nucleus within the mediobasal hypothalamus could be candidate deep-brain photoreceptive molecule in Japanese quail. Investigation of the functional involvement of mammal-like melanopsin-expressing cells in photoperiodism will be required for further conclusions. [ABSTRACT FROM AUTHOR]

Modern logistics processes and systems can feature extremely complicated dynamics. Agent Based Modeling is emerging as a powerful modeling tool for design, analysis and control of such logistics systems. However, the complexity of the model itself can be overwhelming and mathematical meta-modeling tools are needed that aggregate information and enable fast and accurate decision making and control system design. Here we present Koopman Mode Analysis (KMA) as such a tool. KMA uncovers exponentially growing, decaying or oscillating collective patterns in dynamical data. We apply the methodology to two problems, both of which exhibit a bifurcation in dynamical behavior, but feature very different dynamics: Medical Treatment Facility (MTF) logistics and ship fueling (SF) logistics. The MTF problem features a transition between efficient operation at low casualty rates and inefficient operation beyond a critical casualty rate, while the SF problem features a transition between short mission life at low initial fuel levels and sustained mission beyond a critical initial fuel level. Both bifurcations are detected by analyzing the spectrum of the associated Koopman operator. Mathematical analysis is provided justifying the use of the Dynamic Mode Decomposition algorithm in punctuated linear decay dynamics that is featured in the SF problem. [ABSTRACT FROM AUTHOR]

Background: The continued practice of a sport linked to the unilateral predominance of the dominant side can provoke chronic asymmetric adaptations in the myotendinous structure and mechanical properties. Objectives: The main purpose was to determine whether asymmetry between the preferred and non-preferred lower limb is present in the lower limb tendon structure, muscle architecture and stiffness values of professional badminton players. Methods: Sixteen male professional badminton players (age = 24.1 ± 6.7 years; body height = 177.90 ± 7.53 cm) participated in this study. The muscle architecture of the vastus lateralis (VL), medial gastrocnemius (MG) and lateral gastrocnemius (LG) and the structure of patellar and Achilles tendons were measured in the dominant and non-dominant lower limb with ultrasonography. Stiffness was also measured at the same points with a hand-held MyotonPro. Significant differences between the dominant and non-dominant lower limb were determined using Student’s t test for related samples. Results: Bilateral differences were observed for thickness, width and cross-sectional area (CSA) in both tendons showing higher values for the dominant side: patellar tendon CSA (2.02 ± 0.64 vs. 1.51 ± 0.42 cm2; p < 0.05) and Achilles tendon CSA (1.12 ± 0.18 vs. 0.92 ± 0.28 cm2; p < 0.05). No significant differences were observed in muscle architecture and myotonic variables between the dominant and non-dominant lower limb. Conclusions: The prolonged practice of badminton caused asymmetries in the CSA, width and thickness of the patellar and Achilles tendon between the dominant and non-dominant lower limbs. No bilateral differences were found in the muscle architecture of VL, MG and LG or in the stiffness of any muscle or tendon analyzed. [ABSTRACT FROM AUTHOR]

Background: While drink driving continues to be significantly more common among male drivers, there is evidence from many countries that shows a growing trend of women engaging in this risky behaviour. The aims of the current study were threefold: (i) determine to what extent a sample of women drivers reported engaging in drink driving behaviour by expanding the construct into a range of definitions, (ii) determine if there were significant differences in self-reported engagement in drink driving behaviours in accordance with hazardous drinking behaviour, and (iii) identify which situational or personal factors would increase women drivers’ likelihood to engage in drink driving through presenting a range of scenarios. Method: Data were collected using an on-line, purpose-designed survey and promoted to reach women aged 17 years and older, living in Queensland, Australia. In addition to questions relating to demographic characteristics, participants completed items relating to engagement in seven drink driving related behaviours in the previous 12-month period, hazardous drinking as measured by the Alcohol Use Disorders Identification Test, and likelihood of driving when unsure if over the legal limit for licence type across a range of scenarios manipulating different situational factors. A total of 644 valid responses were received in the two-week period the study was advertised. Results: The results demonstrate women’s self-reported engagement in drink driving behaviour ranged from 12.6% (driving when they believed they were over the legal limit) to over 50.0% (driving when unsure if over the legal limit the morning after drinking alcohol) and was significantly more likely among those who reported hazardous levels of alcohol use. Circumstances in which women reported they would drive when unsure if over the legal BAC limit were when they were a few blocks from home, if they subjectively felt they were not too intoxicated, or if they needed their car to get somewhere the next morning. Conclusion: Examining drink driving behaviour by way of responses to nuanced definitions provided valuable insight into self-reported engagement in the behaviour and highlights the usefulness of multi-measure dependent variables in order to illuminate a more accurate acknowledgement into both the type (and extent) of drink driving behaviours. [ABSTRACT FROM AUTHOR]

Considering the benefits that students report when evaluating physical education classes, the purpose of the present study was to analyse the relationships between the assignment of student responsibility in the evaluation, motivational variables and the satisfaction with the physical education classes, using The Theory of Self-determination as a support method. The sample for this study was 922 students, of both genres and in Compulsory Secondary Education, aged between 14 and 18 years. To carry out the study, the Student's Scale of Responsibility was used in the physical education assessment, the Basic Psychological Needs Measuring Scale, the Percentage Scale for Physical Education Causality and the Satisfaction Scale in Physical Education. The results of the structural equations model revealed a good adjustment to the data. This finding highlights the importance of giving responsibilities to the students in the evaluation process, in order to satisfy the psychological needs of the students and, therefore, self-determined motivation. Additionally, the satisfaction of psychological needs and self-determined motivation increase satisfaction towards physical education classes. [ABSTRACT FROM AUTHOR]

This scoping review presents an overview of cognitive and social congruence in peer assisted learning (PAL), as the positive effects of PAL have been shown to rely on these critical factors. The scoping review followed the guidelines of the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Databases were systematically searched for articles that focus on PAL and cognitive and social congruence. Participants of the studies included were medical, health science, polytechnic, law and paramedic students. Studies that assessed cognitive and social congruence by questionnaires with a 5-point Likert scale were regarded for meta-analytic pooling. Sixteen of 786 identified articles were included in the review, whereof 9 studies were considered for meta-analytic pooling. The meta-analytic pooling showed that tutees tend to see their student tutors as cognitively (Mweighted = 3.84; range of Mweighted = 2.69–4.56) and socially congruent (Mweighted = 3.95; range of Mweighted = 2.33–4.57). Further, characteristics of student tutors are summarized. This scoping review presents an overview and operationalization of cognitive and social congruence in PAL. Based on the presented meta-analytic pooling, cognitive and social congruence were found to represent relevant key factors in the PAL context. Thus, this theoretical background should be acknowledged as a core concept for tutorials within the medical curriculum. [ABSTRACT FROM AUTHOR]

Objective: Analyze the measurement invariance and the factor structure of the Patient Health Questionnaire-9 (PHQ-9) in the Peruvian population. Method: Secondary data analysis performed using cross-sectional data from the Health Questionnaire of the Demographic and Health Survey in Peru. Variables of interest were the PHQ-9 and demographic characteristics (sex, age group, level of education, socioeconomic status, marital status, and area of residence). Factor structure was evaluated by standard confirmatory factor analysis (CFA), and measurement invariance by multi-group CFA, using standard goodness-of-fit indices criteria for interpreting results from both CFAs. Analysis of the internal consistency (α and ω) was also pursued. Results: Data from 30,449 study participants were analyzed, 56.7% were women, average age was 40.5 years (standard deviation (SD) = 16.3), 65.9% lived in urban areas, 74.6% were married, and had 9 years of education on average (SD = 4.6). From standard CFA, a one-dimensional model presented the best fit (CFI = 0.936; RMSEA = 0.089; SRMR = 0.039). From multi-group CFA, all progressively restricted models had ΔCFI<0.01 across almost all groups by demographic characteristics. PHQ-9 reliability was optimal (α = ω = 0.87). Conclusions: The evidence presents support for the one-dimensional model and measurement invariance of the PHQ-9 measure, allowing for reliable comparisons between sex, age groups, education level, socioeconomic status, marital status, and residence area, and recommends its use within the Peruvian population. [ABSTRACT FROM AUTHOR]

Of the fast ionotropic synapses, glycinergic synapses are the least well understood, but are vital for the maintenance of inhibitory signaling in the brain and spinal cord. Glycinergic signaling comprises half of the inhibitory signaling in the spinal cord, and glycinergic synapses are likely to regulate local nociceptive processing as well as the transmission to the brain of peripheral nociceptive information. Here we have investigated the rapid and prolonged potentiation of glycinergic synapses in the superficial dorsal horn of young male and female mice after brief activation of NMDA receptors (NMDARs). Glycinergic inhibitory postsynaptic currents (IPSCs) evoked with lamina II-III stimulation in identified GABAergic neurons in lamina II were potentiated by bath-applied Zn2+ and were depressed by the prostaglandin PGE2, consistent with the presence of both GlyRα1- and GlyRα3-containing receptors. NMDA application rapidly potentiated synaptic glycinergic currents. Whole-cell currents evoked by exogenous glycine were also readily potentiated by NMDA, indicating that the potentiation results from altered numbers or conductance of postsynaptic glycine receptors. Repetitive depolarization alone of the postsynaptic GABAergic neuron also potentiated glycinergic synapses, and intracellular EGTA prevented both NMDA-induced and depolarization-induced potentiation of glycinergic IPSCs. Optogenetic activation of trpv1 lineage afferents also triggered NMDAR-dependent potentiation of glycinergic synapses. Our results suggest that during peripheral injury or inflammation, nociceptor firing during injury is likely to potentiate glycinergic synapses on GABAergic neurons. This disinhibition mechanism may be engaged rapidly, altering dorsal horn circuitry to promote the transmission of nociceptive information to the brain. [ABSTRACT FROM AUTHOR]

Whale sharks (Rhincodon typus) are typically dispersed throughout their circumtropical range, but the species is also known to aggregate in specific coastal areas. Accurate site descriptions associated with these aggregations are essential for the conservation of R. typus, an Endangered species. Although aggregations have become valuable hubs for research, most site descriptions rely heavily on sightings data. In the present study, visual census, passive acoustic monitoring, and long range satellite telemetry were combined to track the movements of R. typus from Shib Habil, a reef-associated aggregation site in the Red Sea. An array of 63 receiver stations was used to record the presence of 84 acoustically tagged sharks (35 females, 37 males, 12 undetermined) from April 2010 to May 2016. Over the same period, identification photos were taken for 76 of these tagged individuals and 38 were fitted with satellite transmitters. In total of 37,461 acoustic detections, 210 visual encounters, and 33 satellite tracks were analyzed to describe the sharks’ movement ecology. The results demonstrate that the aggregation is seasonal, mostly concentrated on the exposed side of Shib Habil, and seems to attract sharks of both sexes in roughly equal numbers. The combined methodologies also tracked 15 interannual homing-migrations, demonstrating that many sharks leave the area before returning in later years. When compared to acoustic studies from other aggregations, these results demonstrate that R. typus exhibits diverse, site-specific ecologies across its range. Sightings-independent data from acoustic telemetry and other sources are an effective means of validating more common visual surveys. [ABSTRACT FROM AUTHOR]

Purpose: The Edinburgh Postnatal Depression Scale (EPDS) aims at detecting postpartum depression. It has been hypothesized that a subscale (items 3, 4, 5) may detect anxiety. The aim of this study is to assess whether this EPDS anxiety subscale is present in a community-based dataset, and if so, to assess its validity and stability during the first six months postpartum. Methods: We obtained EPDS data of a community sample of 1612 women at 1 month, with follow-up at 3 and 6 months, postpartum (Post-Up study). We performed an exploratory factor analysis on the EPDS forcing two- and three-factor solutions. We assessed the correlations of the extracted factor subscales and the total EPDS with the short-form of the STAI (STAI-6). We examined the stability of the identified factors by means of a confirmatory factor analysis (CFA), using the EPDS data collected at 3 and 6 months postpartum. Results: Both the two- and three-factor solutions contained a hypothesized anxiety subscale of items 3,4,5,10, and fitted well with the 3- and 6-months EPDS data, with CFI and TLI values >.99 and RMSEA and SRMR values < .035 and < .45. The subscale’s Pearson correlations with the STAI-6 were moderate: .516, compared to .643 for the total EPDS. Conclusions: The factor structure of the EPDS is stable across the first six months postpartum, and includes the subscale assumed to represent anxiety. However, this subscale as well as the total EPDS correlate only moderately with anxiety criteria. Using the EPDS thus does not imply adequate screening for anxiety. [ABSTRACT FROM AUTHOR]

Due to the fast speed of data generation and collection from advanced equipment, the amount of data obviously overflows the limit of available memory space and causes difficulties achieving high learning accuracy. Several methods based on discard-after-learn concept have been proposed. Some methods were designed to cope with a single incoming datum but some were designed for a chunk of incoming data. Although the results of these approaches are rather impressive, most of them are based on temporally adding more neurons to learn new incoming data without any neuron merging process which can obviously increase the computational time and space complexities. Only online versatile elliptic basis function (VEBF) introduced neuron merging to reduce the space-time complexity of learning only a single incoming datum. This paper proposed a method for further enhancing the capability of discard-after-learn concept for streaming data-chunk environment in terms of low computational time and neural space complexities. A set of recursive functions for computing the relevant parameters of a new neuron, based on statistical confidence interval, was introduced. The newly proposed method, named streaming chunk incremental learning (SCIL), increases the plasticity and the adaptabilty of the network structure according to the distribution of incoming data and their classes. When being compared to the others in incremental-like manner, based on 11 benchmarked data sets of 150 to 581,012 samples with attributes ranging from 4 to 1,558 formed as streaming data, the proposed SCIL gave better accuracy and time in most data sets. [ABSTRACT FROM AUTHOR]

Personal control relies on the expectation that events are contingent upon one’s own behavior. A common ‘inconsistency compensation approach’ posits that a violation of expectancies in social interaction triggers aversive arousal and compensatory effort. Following this approach, we tested the hypothesis that interventions affecting participants' decisions violate the expected personal control. In a modified version of the established cyberball paradigm, participants were not excluded, but consistently included. However, their decisions regarding the recipient of a ball throw in the virtual game were occasionally overruled (expectancy violation). We hypothesized that this intervention will trigger a P3 response in event-related brain potentials (ERP). Since this component is related to subjective expectancies, its amplitude was assumed to depend on the frequency of interventions (independent factor: loss of control). Further, we manipulated the vertical position of the participants’ avatar on the computer screen (independent factor: verticality). Building on research showing that verticality is related to the self-assigned power and influences the expected level of control, we hypothesized that the ERP effects of intervention should be more pronounced for participants with avatars in superior position. As predicted, both experimental factors interactively affected the expression of the ERP response: In case of low intervention frequency, P3 amplitudes were significantly pronounced if the participants’ avatar was positioned above as compared to below co-players (high > low self-assigned power). The effect of verticality could be traced back to a lack of adaptation of P3 amplitudes to recurring aversive events. By demonstrating that loss of control triggers ERP effects corresponding to those triggered by social exclusion, this study provides further evidence for a common cognitive mechanism in reactions to aversive events based on an inconsistency in expectancy states. [ABSTRACT FROM AUTHOR]

Background: The narrative surrounding the management of potentially resectable pancreatic cancer is complex. Surgical resection is the only potentially curative treatment. However resection rates are low, the risk of operative morbidity and mortality are high, and survival outcomes remain poor. The aim of this study was to create a prognostic Bayesian network that pre-operatively makes personalized predictions of post-resection survival time of 12months or less and also performs post-operative prognostic updating. Methods: A Bayesian network was created by synthesizing data from PubMed post-resection survival analysis studies through a two-stage weighting process. Input variables included: inflammatory markers, tumour factors, tumour markers, patient factors and, if applicable, response to neoadjuvant treatment for pre-operative predictions. Prognostic updating was performed by inclusion of post-operative input variables including: pathology results and adjuvant therapy. Results: 77 studies (n = 31,214) were used to create the Bayesian network, which was validated against a prospectively maintained tertiary referral centre database (n = 387). For pre-operative predictions an Area Under the Curve (AUC) of 0.7 (P value: 0.001; 95% CI 0.589–0.801) was achieved accepting up to 4 missing data-points in the dataset. For prognostic updating an AUC 0.8 (P value: 0.000; 95% CI:0.710–0.870) was achieved when validated against a dataset with up to 6 missing pre-operative, and 0 missing post-operative data-points. This dropped to AUC: 0.7 (P value: 0.000; 95% CI:0.667–0.818) when the post-operative validation dataset had up to 2 missing data-points. Conclusion: This Bayesian network is currently unique in the way it utilizes PubMed and patient level data to translate the existing empirical evidence surrounding potentially resectable pancreatic cancer to make personalized prognostic predictions. We believe such a tool is vital in facilitating better shared decision-making in clinical practice and could be further developed to offer a vehicle for delivering personalized precision medicine in the future. [ABSTRACT FROM AUTHOR]

Understanding the optimization objectives that shape shoot architectures remains a critical problem in plant biology. Here, we performed 3D scanning of 152 Arabidopsis shoot architectures, including wildtype and 10 mutant strains, and we uncovered a design principle that describes how architectures make trade-offs between competing objectives. First, we used graph-theoretic analysis to show that Arabidopsis shoot architectures strike a Pareto optimal that can be captured as maximizing performance in transporting nutrients and minimizing costs in building the architecture. Second, we identify small sets of genes that can be mutated to shift the weight prioritizing one objective over the other. Third, we show that this prioritization weight feature is significantly less variable across replicates of the same genotype compared to other common plant traits (e.g., number of rosette leaves, total volume occupied). This suggests that this feature is a robust descriptor of a genotype, and that local variability in structure may be compensated for globally in a homeostatic manner. Overall, our work provides a framework to understand optimization trade-offs made by shoot architectures and provides evidence that these trade-offs can be modified genetically, which may aid plant breeding and selection efforts. [ABSTRACT FROM AUTHOR]

Swarming is a characteristic behavior of bats that occurs in different social contexts. We studied the swarming behavior of Myotis nattereri at a maternity colony and at an autumn swarming site in South-West Germany by using synchronized sound and video recordings. Swarming was always associated with social vocalizations consisting of four frequently occurring call types. Call type A was a short call with a broadband steep-shallow-steep downward frequency modulation. Call type B consisted of two elements beginning with a broadband upward hooked element followed by a steep frequency modulated element. Call type C showed a characteristic rapid downward-upward-downward frequency modulation. Call type D was a long sinusoidal trill-like call with high variability in signal structure. All call types were recorded at the maternity colony, as well as at the autumn swarming site, but the incidence of each call type differed distinctly between the study sites. At the maternity roost, type A calls were most commonly produced. We found evidence for an individual signature in this call type and suggest that this social call has the function of a contact call in Natterer’s bats. At the autumn swarming site, type D calls were the most common social calls; in contrast, this call type was recorded only twice at the maternity roost. The occurrence of trills mainly at the autumn swarming site and their high variability suggests that trills function as male advertisement calls in M. nattereri. [ABSTRACT FROM AUTHOR]

Light traps are used to determine the temporal and spatial dynamics of the migratory brown planthoppers (BPHs) Nilaparvata lugens. But very little is known whether newly emerged adults respond to local light traps during the emigration period. Thus, it is important to evaluate the efficiency of light traps in attracting emigrant and immigrant populations to improve forecasting and control of this pest. The migration periods of N. lugens were determined by field surveys in Fuyang, Zhejiang province in 2012 and Yongfu, Guangxi Zhuang Autonomous Region in 2013. Mark-release-recapture experiments with both newly emerged (unflown) and flight experienced (flown) N. lugens were conducted at the two study sites. The marking method did not have any significant effect on the survival or flight capability of the N. lugens. A total of 4800 marked flown and 8400 unflown BPHs were released at a distance of 10, 20 and 30 m from 45-watt fluorescent actinic light traps. The results showed that without wind (< 3.2 m/s) or rainfall conditions, the overall recapture rate of flown BPHs was higher than that of unflown BPHs (9.60% and 0.92%, respectively; χ21 = 589.66, P < 0.0001). Curve estimation regression analysis showed that flown BPHs were attracted to the light source at a distance of 19.77 m, and unflown BPH at a distance of 5.35 m, with these distances corresponding to a 5% recapture rate. Given that the population dynamics of BPHs in the light traps were not synchronous with that in the fields, our results indicate that only a few emerging BPHs in an infested site can be captured locally by light traps. Therefore, care must be taken in estimating the abundance of the sample to absolute local abundance during sedentary and emigration period. [ABSTRACT FROM AUTHOR]

To balance the supply and demand in China's beef market, beef consumption must be scientifically and effectively forecasted. Beef consumption is affected by many factors and is characterized by gray uncertainty. Therefore, gray theory can be used to forecast the beef consumption, In this paper, the structural defects and unreasonable parameter design of the traditional gray model are analyzed. Then, a new gray model termed, EGM(1,1,r), is built, and the modeling conditions and error checking methods of EGM(1,1,r) are studied. Then, EGM(1,1,r) is used to simulate and forecast China’s beef consumption. The results show that both the simulation and prediction precisions of the new model are better than those of other gray models. Finally, the new model is used to forecast China’s beef consumption for the period from 2019–2025. The findings will serve as an important reference for the Chinese government in formulating policies to ensure the balance between the supply and demand for Chinese beef. [ABSTRACT FROM AUTHOR]

Prejudiced attitudes and political nationalism vary widely around the world, but there has been little research on what predicts this variation. Here we examine the ecological and cultural factors underlying the worldwide distribution of prejudice. We suggest that cultures grow more prejudiced when they tighten cultural norms in response to destabilizing ecological threats. A set of seven archival analyses, surveys, and experiments (∑N = 3,986,402) find that nations, American states, and pre-industrial societies with tighter cultural norms show the most prejudice based on skin color, religion, nationality, and sexuality, and that tightness predicts why prejudice is often highest in areas of the world with histories of ecological threat. People’s support for cultural tightness also mediates the link between perceived ecological threat and intentions to vote for nationalist politicians. Results replicate when controlling for economic development, inequality, conservatism, residential mobility, and shared cultural heritage. These findings offer a cultural evolutionary perspective on prejudice, with implications for immigration, intercultural conflict, and radicalization. [ABSTRACT FROM AUTHOR]

Previous studies compared the effects of gradual and sudden adaptation on intermanual transfer to find out whether transfer depends on awareness of the perturbation. Results from different groups were contradictory. Since results of our own study suggest that awareness depends on perturbation size, we hypothesize that awareness-related intermanual transfer will only appear after adaptation to a large, sudden perturbation but not after adaptation to a small sudden perturbation or a gradual perturbation, large or small. To confirm this, four groups (S30, G30, S75, G75) of subjects performed out-and-back reaching movements with their right arm. In a baseline block, they received veridical visual feedback of hand position. In the subsequent adaptation block, feedback was rotated by 30 deg (S30, G30) or 75 deg (S75, G75). This rotation was either introduced suddenly (S30, S75) or gradually in steps of 3 deg (G30, G75). After the adaptation block, subjects did an awareness test comprising exclusion and inclusion conditions. The experiment concluded with an intermanual transfer block, in which movements were performed with the left arm under rotated feedback, and a washout block again under veridical feedback. We used a hierarchical Bayesian model to estimate individual movement directions and group averages. The movement directions in different conditions were then used to calculate group and individual indexes of adaptation, awareness, unawareness, transfer and washout. Both awareness and transfer were larger in S75 than in other groups, while unawareness and washout were smaller in S75 than in other groups. Furthermore, the size of awareness indices correlated to intermanual transfer across subjects, even when transfer was normalized to final adaptation level. Thus, we show for the first time that the amount of intermanual transfer directly relates to the extent of awareness of the learned perturbation. [ABSTRACT FROM AUTHOR]

The primary objective of this study is to compare pedestrian evacuation strategies in the large-scale public space (LPS) using microscopic model. Data were collected by video recording from Tian-yi square for 36 hours in city of Ningbo, China. A pedestrian evacuation simulation model was developed based on the social force model (SFM). The simulation model parameters, such as reaction time, elasticity coefficient, sliding coefficient, et al, were calibrated using the real data extracted from the video. Five evacuation strategies, strategy 1 (S1) to strategy 5 (S5) involving distance, density and capacity factors were simulated and compared by indicators of evacuation time and channel utilization rate, as well as the evacuation efficiency. The simulation model parameters calibration results showed that a) the pedestrians walking speed is 1.0 ~ 1.5m/s; b) the pedestrians walking diameter is 0.3 ~ 0.4m; c) the frequency of pedestrian arrival and departure followed multi-normal distribution. The simulation results showed that, (a) in terms of total evacuation time, the performance of S4 and S5 which considering the capacity and density factors were best in all evacuation scenarios, the performance of S3 which only considering the density factor was the worst, relatively, and S1 and S2 which considering the distance factor were in the middle. (b) the utilization rate of channels under S5 strategy was better than other strategies, which performs best in the balance of evacuation. S3 strategy was the worst, and S1, S2 and S4 were in the middle. (c) in terms of the evacuation efficiency, when the number of evacuees is within 2, 500 peds, the S1 and S2 strategy which considering the distance factor have best evacuation efficiency than other strategies. And when the number of evacuees is above 2, 500 peds, the S4 and S5 strategy which considering the capacity factor are better than others. [ABSTRACT FROM AUTHOR]

Objectives: The study aim was to determine if a difference exists in skinfold thickness measured by two interchangeable approaches; (1) supraspinale skinfold recommended in the Heath-Carter method and (2) iliac crest skinfold measurement. The question arises as to whether each approach has a similar or different effect on endomorphy determination, and whether there is a possibility to estimate the supraspinale skinfold based on other skinfold measurements. Methods: A group of 186 male and 161 female students participated in this study. Anthropometric examination included all somatic measurements, as recommended in the Heath-Carter protocol, and the iliac crest skinfold measurement. Estimation of the supraspinale skinfold was performed based on the multiple linear regression procedure. Results: Skinfold thickness measured in the supraspinale and iliac crest differed (p<0.001) in both men (5.41±1.65 mm and 9.55±4.05 mm, respectively) and women (8.87±4.08 mm and 15.20±6.85 mm), respectively. Endomorphy was significantly higher (0.46 in men, 0.63 in women) when the iliac crest skinfold was used. Subscapular skinfold and iliac crest skinfolds were included in the linear regression model for supraspinale skinfold estimation (R2 = 0.724, SE = 0.9 mm and R2 = 0.947, SE = 2.3 mm for men and women, respectively). Conclusion: Two common skinfold approaches produced different measurements between the supraspinale and iliac crest skinfolds, which subsequently affected estimated endomorphy. Regression equations for supraspinale skinfold enabled correction of endomorphy in the case of improperly applied measurement (i.e. iliac crest) and thus, could allow for uniform somatotype estimation according to Carter and Heath approach. [ABSTRACT FROM AUTHOR]

Recently it has been shown that building networks from time series allows to study complex systems to characterize them when they go through a phase transition. This give us the opportunity to study this systems from a entire new point of view. In the present work we have used the natural and horizontal visualization algorithms to built networks of two popular models, which present phase transitions: the Ising model and the Kuramoto model. By measuring some topological quantities as the average degree, or the clustering coefficient, it was found that the networks retain the capability of detecting the phase transition of the system. From our results it is possible to establish that both visibility algorithms are capable of detecting the critical control parameter, as in every quantity analyzed (the average degree, the average path and the clustering coefficient) there is a minimum or a maximum value. In the case of the natural visualization algorithm, the average path results are much more noisy than in the other quantities in the study. Specially for the Kuramoto Model, which in this case does not allow a detection of the critical point at plain sight as for the other quantities. The horizontal visualization algorithm has proven to be more explicit in every quantity, as every one of them show a clear change of behavior before and after the critical point of the transition. [ABSTRACT FROM AUTHOR]

This paper examines whether tobacco expenditure leads to the crowding out or crowding in of different expenditure items in South Africa. We apply genetic matching to expenditure quartiles of the 2010/2011 South African Income and Expenditure Survey. Genetic matching is a more appealing approach for dealing with the endogeneity of tobacco expenditure that often plagues studies using systems of demand equations. Further, genetic matching provides transparent measures of covariate balance giving the analyst objective means of assessing match success. We find that the poorest tobacco consuming households in South Africa consistently allocate smaller budget shares towards food items than non-smoking households. Specifically, we find that dairy, fruits, nuts and oils are displaced in favour of tobacco expenditure in the two poorest quartiles. Unsurprisingly, food items are never displaced for households in the top two quartiles, given these households’ greater access to resources. Like other studies in the literature, we find that tobacco expenditure consistently crowds-in alcohol across all quartiles confirming the strong complementarities between the two. [ABSTRACT FROM AUTHOR]

Noise fears represent a highly prevalent welfare problem in dogs. An online survey was performed to explore severity and progression of firework fears in dogs, and relationships with demographics, health, behaviour problems and owners’ training efforts to prevent or alleviate firework fears. Fifty-two percent of dogs in the sample (N = 1225) were at least partially affected by firework fears, and the majority developed a fear of fireworks in the first year of life, with a decreasing frequency of new occurrences up until seven years, and only few newly affected dogs beyond this age. While almost three-quarters of fearful dogs had recovered by the next morning following firework exposure, recovery took up to one day in 10%, up to one week in 12%, and several weeks or even months in >3%. Univariate analyses indicated a significant effect of breed group, age, sex, neuter status, origin and age at acquisition on severity of firework fears in dogs. However, binomial models including multiple predictors of presence/ absence of firework fears identified only age, breed group (mixed breeds being most affected), health problems, and an interaction between health problems and age as significant predictors. This discrepancy might be explained by collinearities of predictors and underlying differences between mixed-breed dogs and purebreds, such as mixed breeds being acquired from shelters more often and being neutered more often. Firework fears are highly correlated with fears of gunshots and thunder, and to a low extent with fears of other noises, but not with any other behavioural problems. Both improvement and deterioration of firework fears were frequently reported. While an early age of onset and breed differences point to a strong genetic contribution to firework fears, the data indicate that training puppies or non-fearful adults to associate the noise with positive stimuli is highly effective in preventing later development of firework fears. [ABSTRACT FROM AUTHOR]

Value-based decision-making involves trading off the cost associated with an action against its expected reward. Research has shown that both physical and mental effort constitute such subjective costs, biasing choices away from effortful actions, and discounting the value of obtained rewards. Facing conflicts between competing action alternatives is considered aversive, as recruiting cognitive control to overcome conflict is effortful. Moreover, engaging control to proactively suppress irrelevant information that could conflict with task-relevant information would presumably also be cognitively costly. Yet, it remains unclear whether the cognitive control demands involved in preventing and resolving conflict also constitute costs in value-based decisions. The present study investigated this question by embedding irrelevant distractors (flanker arrows) within a reversal-learning task, with intermixed free and instructed trials. Results showed that participants learned to adapt their free choices to maximize rewards, but were nevertheless biased to follow the suggestions of irrelevant distractors. Thus, the perceived cost of investing cognitive control to suppress an external suggestion could sometimes trump internal value representations. By adapting computational models of reinforcement learning, we assessed the influence of conflict at both the decision and learning stages. Modelling the decision showed that free choices were more biased when participants were less sure about which action was more rewarding. This supports the hypothesis that the costs linked to conflict management were traded off against expected rewards. During the learning phase, we found that learning rates were reduced in instructed, relative to free, choices. Learning rates were further reduced by conflict between an instruction and subjective action values, whereas learning was not robustly influenced by conflict between one’s actions and external distractors. Our results show that the subjective cognitive control costs linked to conflict factor into value-based decision-making, and highlight that different types of conflict may have different effects on learning about action outcomes. [ABSTRACT FROM AUTHOR]

State-space and action representations form the building blocks of decision-making processes in the brain; states map external cues to the current situation of the agent whereas actions provide the set of motor commands from which the agent can choose to achieve specific goals. Although these factors differ across environments, it is currently unknown whether or how accurately state and action representations are acquired by the agent because previous experiments have typically provided this information a priori through instruction or pre-training. Here we studied how state and action representations adapt to reflect the structure of the world when such a priori knowledge is not available. We used a sequential decision-making task in rats in which they were required to pass through multiple states before reaching the goal, and for which the number of states and how they map onto external cues were unknown a priori. We found that, early in training, animals selected actions as if the task was not sequential and outcomes were the immediate consequence of the most proximal action. During the course of training, however, rats recovered the true structure of the environment and made decisions based on the expanded state-space, reflecting the multiple stages of the task. Similarly, we found that the set of actions expanded with training, although the emergence of new action sequences was sensitive to the experimental parameters and specifics of the training procedure. We conclude that the profile of choices shows a gradual shift from simple representations to more complex structures compatible with the structure of the world. [ABSTRACT FROM AUTHOR]

Background: Although trachoma causes more cases of preventable blindness than any other infectious disease, a combination of strategies is reducing its global prevalence. As a district moves toward eliminating trachoma as a public health problem, national programs conduct trachoma impact surveys (TIS) to assess whether to stop preventative interventions and trachoma surveillance surveys (TSS) to determine whether the prevalence of active trachoma has rebounded after interventions have halted. In some contexts, programs also conduct trachomatous trichiasis (TT)-only surveys. A few costing studies of trachoma prevalence surveys exist, but none examine TIS, TSS, or TT-only surveys. Methodology/Principal findings: We assessed the incremental financial cost to the national program of TIS, TSS, and TT-only surveys, which are standardized cluster-sampled prevalence surveys. We conducted a retrospective review of expenditures and grant disbursements for TIS and TSS in 322 evaluation units in 11 countries between 2011 and 2018. We also assessed the costs of three pilot and five standard TT-only surveys in four countries between 2017 and 2018. The median cost of TIS and TSS was $8,298 per evaluation unit [interquartile range (IQR): $6,532–$10,111, 2017 USD]. Based on a linear regression with bootstrapped confidence intervals, after controlling for country, costs per survey did not change significantly over time but did decline by $83 per survey implemented in a single round (95% CI: -$108 –-$63). Of total costs, 80% went to survey fieldwork; of that, 58% went towards per diems and 38% towards travel. TT-only surveys cost a median of $9,707 (IQR: $8,537–$11,635); within a given country, they cost slightly more (106% [IQR: 94%–136%]) than TIS and TSS. Conclusions/Significance: The World Health Organization requires trachoma prevalence estimates for validating the elimination of trachoma as a public health problem. This study will help programs improve their planning as they assemble resources for that effort. [ABSTRACT FROM AUTHOR]

Explants of embryonic chick sympathetic and sensory ganglia were found to exhibit asymmetric radial outgrowth of neurites under standard culture conditions with or without exogenous Nerve Growth Factor [NGF]. Opposing sides of an explant exhibited: a) differences in neurite length and, b) differences in neurite morphology. Strikingly, this asymmetry exhibited co-orientation among segregated, neighboring explants. The underlying mechanism(s) of the asymmetry and its co-orientation are not known but appear to depend on cell clustering because dissociated sympathetic neurons do not exhibit co-orientation whereas re-aggregated clusters of cells do. This emergent behavior may be similar to the community effect described in other cell types. If a similar phenomenon exists in the embryo, or in maturity, it may contribute to the establishment of proper orientation of neurite outgrowth during development and/or injury-induced neuronal plasticity. [ABSTRACT FROM AUTHOR]

In order to determine the optimal strategy to run a race on a curved track according to the lane number, we introduce a model based on differential equations for the velocity, the propulsive force and the anaerobic energy which takes into account the centrifugal force. This allows us to analyze numerically the different strategies according to the types of track since different designs of tracks lead to straights of different lengths. In particular, we find that the tracks with shorter straights lead to better performances, while the double bend track with the longest straight leads to the worst performances and the biggest difference between lanes. Then for a race with two runners, we introduce a psychological interaction: there is an attraction to follow someone just ahead, but after being overtaken, there is a delay before any benefit from this interaction occurs. We provide numerical simulations in different cases. Overall, the results agree with the IAAF rules for lane draws in competition, where the highest ranked athletes get the center lanes, the next ones the outside lanes, while the lowest ranked athletes get the inside lanes. [ABSTRACT FROM AUTHOR]

Background: Patients and clinicians endorse the importance of compassionate healthcare but patients report gaps between its perceived importance and its demonstration. Empathy and compassion have been associated with quality of life and significant health outcomes but these characteristics are not optimally measured or used for performance and organizational improvement. Objective: To address these gaps, we conducted a study with the objective of evaluating the properties of the 12-item Schwartz Center Compassionate Care Scale® using psychometric analysis and cognitive debriefing. Methods: Non-hospitalized patients with multiple chronic conditions were sampled using an on-line platform. Classical test theory and Rasch measurement theory were used to evaluate psychometric properties of the scale. Structured questions elicited cognitive responses regarding clarity of each item. Results: Classical test theory analysis confirmed that the 12-item Schwartz Center Compassionate Care Scale is a unidimensional scale with excellent internal consistency and test-retest reliability. Patients’ ratings of compassionate behaviors using the Schwartz Center Compassionate Care Scale correlated significantly with a related instrument designed to measure empathy, demonstrating convergent validity. Rasch measurement theory showed that reducing the number of response options on 3 items in the scale would improve respondents’ discrimination between responses on these items. Although person-item threshold distribution analysis showed that patients may wish to rate compassionate care at levels both higher and lower than the scale permits, items could be ordered on an interval scale from low to high levels of compassionate care. Conclusions: The current 12-item Schwartz Center Compassionate Care Scale demonstrates excellent psychometric properties by Classical Test Theory and Rasch measurement theory. The 12-item Schwartz Center Compassionate Care Scale adds questions related to understanding and discussing emotional, contextual issues and the needs of the patient and family. Easily completed on-line, it could be used for work-place based assessment and feedback to clinicians and performance or quality improvement. [ABSTRACT FROM AUTHOR]

Two critical tasks in multi-criteria group decision making (MCGDM) are to describe criterion values and to aggregate the described information to generate a ranking of alternatives. A flexible and superior tool for the first task is q-rung orthopair fuzzy number (qROFN) and an effective tool for the second task is aggregation operator. So far, nearly thirty different aggregation operators of qROFNs have been presented. Each operator has its distinctive characteristics and can work well for specific purpose. However, there is not yet an operator which can provide desirable generality and flexibility in aggregating criterion values, dealing with the heterogeneous interrelationships among criteria, and reducing the influence of extreme criterion values. To provide such an aggregation operator, Muirhead mean operator, power average operator, partitioned average operator, and Archimedean T-norm and T-conorm operations are concurrently introduced into q-rung orthopair fuzzy sets, and an Archimedean power partitioned Muirhead mean operator of qROFNs and its weighted form are presented and a MCGDM method based on the weighted operator is proposed in this paper. The generalised expressions of the two operators are firstly defined. Their properties are explored and proved and their specific expressions are constructed. On the basis of the specific expressions, a method for solving the MCGDM problems based on qROFNs is then designed. Finally, the feasibility and effectiveness of the method is demonstrated via a numerical example, a set of experiments, and qualitative and quantitative comparisons. [ABSTRACT FROM AUTHOR]

Social capital has long been associated with opportunities of access to valuable resources that individuals, groups, communities, and places can extract from the social structure emerging from their interactions. Despite the overall consensus on the structural signature of social capital, there is still controversy over the relative benefits associated with different types of social structure. In this article, we advocate a two-faceted perspective on social capital, regarded as value originating from both closed (rich in third-party relationships) and open (rich in brokerage opportunities) bridging structures. We uncover these structures from place-centric networks and investigate their association with key socio-economic indicators. To this end, we draw on aggregated mobile phone usage data, and construct the place-centric communication and mobility networks in the city of Abidjan in Côte d’Ivoire. We begin by defining appropriate network metrics to capture the interplay between bonding and bridging social structures in each of the 10 districts (communes) in Abidjan. We then examine the correlation between these metrics and a number of district-level socio-economic indicators related to economic prosperity, wealth, security and democratic participation. Our findings suggest that both closed and open structures can serve as wellsprings of social capital: while closed bonding structures are associated with higher economic prosperity, open bridging structures are associated with increased democratic participation and security. By uncovering sources of social capital from communication and mobility place-centric networks in a developing country, our work contributes to a better understanding of how these networks could be used to enhance and sustain socio-economic growth and prosperity, and ultimately paves the way towards a broader comparative study of social capital in developed and developing countries. [ABSTRACT FROM AUTHOR]

Distinguishing certain and uncertain information is of crucial importance both in the scientific field in the strict sense and in the popular scientific domain. In this paper, by adopting an epistemic stance perspective on certainty and uncertainty, and a mixed procedure of analysis, which combines a bottom-up and a top-down approach, we perform a comparative study (both qualitative and quantitative) of the uncertainty linguistic markers (verbs, non-verbs, modal verbs, conditional clauses, uncertain questions, epistemic future) and their scope in three different corpora: a historical corpus of 80 biomedical articles from the British Medical Journal (BMJ) 1840–2007; a corpus of 12 biomedical articles from BMJ 2013, and a contemporary corpus of 12 scientific popular articles from Discover 2013. The variables under observation are time, structure (IMRaD vs no-IMRaD) and genre (scientific vs popular articles). We apply the Generalized Linear Models analysis in order to test whether there are statistically significant differences (1) in the amount of uncertainty among the different corpora, and (2) in the categories of uncertainty markers used by writers. The results of our analysis reveal that (1) in all corpora, the percentages of uncertainty are always much lower than that of certainty; (2) uncertainty progressively diminishes over time in biomedical articles (in conjunction with their structural changes–IMRaD–and to the increase of the BMJ Impact Factor); and (3) uncertainty is slightly higher in scientific popular articles (Discover 2013) as compared to the contemporary corpus of scientific articles (BMJ 2013). Nevertheless, in all corpora, modal verbs are the most used uncertainty markers. These results suggest that not only do scientific writers prefer to communicate their uncertainty with markers of possibility rather than those of subjectivity but also that science journalists prefer using a third-person subject followed by modal verbs rather than a first-person subject followed by mental verbs such as think or believe. [ABSTRACT FROM AUTHOR]

Due to the rapid technological evolution and communications accessibility, data generated from different sources of information show an exponential growth behavior. That is, volume of data samples that need to be analyzed are getting larger, so the methods for its processing have to adapt to this condition, focusing mainly on ensuring the computation is efficient, especially when the analysis tools are based on computational intelligence techniques. As we know, if you do not have a good control of the handling of the volume of the data, some techniques that are based on learning iterative processes could represent an excessive load of computation and could take a prohibitive time in trying to find a solution that could not come close to desired. There are learning methods known as full batch, online and mini-batch, and they represent a good strategy to this problem since they are oriented to the processing of data according to the size or volume of available data samples that require analysis. In this first approach, synthetic datasets with a small and medium volume were used, since the main objective is to define its implementation and in experimentation phase through regression analysis obtain information that allows us to assess the performance and behavior of different learning methods under distinct conditions. To carry out this study, a Mamdani based neuro-fuzzy system with center-of-sets defuzzification with support of multiple inputs and outputs was designed and implemented that had the flexibility to use any of the three learning methods, which were implemented within the training process. Finally, results show that the learning method with best performances was Mini-Batch when compared to full batch and online learning methods. The results obtained by mini-batch learning method are as follows; mean correlation coefficient with 0.8268 and coefficient of determination with 0.7444, and is also the method with better control of the dispersion between the results obtained from the 30 experiments executed per each dataset processed. [ABSTRACT FROM AUTHOR]

Radiocarbon dating Pacific archaeological sites is fraught with difficulties. Often situated in coastal beach ridges or sand dunes, these sites exhibit horizontal and vertical disturbances, datable materials such as wood charcoal are typically highly degraded, may be derived from old trees or driftwood unless specifically identified to short-lived material, while bone collagen rarely survives in tropical conditions. Shell, therefore, is the most logical material for dating Pacific sites since it is resistant to alteration, can be sampled to ensure only the last few seasons of growth are represented and is often closely tied to human economic activities. However, shell radiocarbon (14C) dating has been plagued by interpretive problems largely due to our limited knowledge of the 14C cycle in nearshore marine and estuarine environments. Consequently, shell dates are typically ignored in regional chronometric evaluations and in recent years shell is often avoided for dating altogether. Recent advances in our understanding of the source of shell 14C as well as the development of the first South Pacific Gyre model of changing marine 14C over time, combined with Bayesian statistical modelling, now provide us with insight into the value of these shell radiocarbon dates. Here we present a revision of the age of the To’aga site on Ofu Island–an early occupation site associated with the initial Polynesian Plainware period in Sāmoa, the earliest use of which we date to between 2785 and 2607 cal BP (68% probability). [ABSTRACT FROM AUTHOR]

Objectives: Stigma toward people with mental health problems (MHP) in primary health care (PHC) settings is an important public health challenge. Research on stigma toward MHP is relatively scarce in Chile and Latin America, as are instruments to measure stigma that are validated for use there. The present study aims to validate the Opening Minds Scale for Health Care Professionals (OMS-HC) among staff and providers in public Chilean PHC clinics, and examine differences in stigma by sociodemographic characteristics. Methods: 803 participants from 34 PHC clinics answered a self-administered questionnaire. Confirmatory factor analysis was completed. Average 15-item OMS-HC scores were calculated, and means were compared via t-test or ANOVA to identify group differences. Correlations of OMS-HC scores with other commonly used stigma scores were calculated to evaluate construct validity. Results: The 3-factor OMS-HC structure was confirmed in this population. The average OMS-HC (α = 0.69) score was 34.55 (theoretical range 15–75). Significantly lower (less stigmatizing) mean OMS-HC scores were found in those with additional training and/or personal experience with MHP. Conclusion: The validated, Spanish version of OMS-HC can be of use to further research stigma toward MHP in Chile and Latin America, advancing awareness and inspiring interventions to reduce stigma in the future. [ABSTRACT FROM AUTHOR]

Objective: To assess the accuracy of WMH-ICS online screening scales for evaluating four common mental disorders (Major Depressive Episode[MDE], Mania/Hypomania[M/H], Panic Disorder[PD], Generalized Anxiety Disorder[GAD]) and suicidal thoughts and behaviors[STB] used in the UNIVERSAL project. Methods: Clinical diagnostic reappraisal was carried out on a subsample of the UNIVERSAL project, a longitudinal online survey of first year Spanish students (18–24 years old), part of the WHO World Mental Health-International College Student (WMH-ICS) initiative. Lifetime and 12-month prevalence of MDE, M/H, PD, GAD and STB were assessed with the Composite International Diagnostic Interview-Screening Scales [CIDI-SC], the Self-Injurious Thoughts and Behaviors Interview [SITBI] and the Columbia-Suicide Severity Rating Scale [C-SSRS]. Trained clinical psychologists, blinded to responses in the initial survey, administered via telephone the Mini-International Neuropsychiatric Interview [MINI]. Measures of diagnostic accuracy and McNemar χ2 test were calculated. Sensitivity analyses were conducted to maximize diagnostic capacity. Results: A total of 287 students were included in the clinical reappraisal study. For 12-month and lifetime mood disorders, sensitivity/specificity were 67%/88.6% and 65%/73.3%, respectively. For 12-month and lifetime anxiety disorders, these were 76.8%/86.5% and 59.6%/71.1%, and for 12-month and lifetime STB, 75.9%/94.8% and 87.2%/86.3%. For 12-month and lifetime mood disorders, anxiety disorders and STB, positive predictive values were in the range of 18.1–55.1% and negative predictive values 90.2–99.0%; likelihood ratios positive were in the range of 2.1–14.6 and likelihood ratios negative 0.1–0.6. All outcomes showed adequate areas under the curve [AUCs] (AUC>0.7), except M/H and PD (AUC = 0.6). Post hoc analyses to select optimal diagnostic thresholds led to improved concordance for all diagnoses (AUCs>0.8). Conclusion: The WMS-ICS survey showed reasonable concordance with the MINI telephone interviews performed by mental health professionals, when utilizing optimized cut-off scores. The current study provides initial evidence that the WMS-ICS survey might be useful for screening purposes. [ABSTRACT FROM AUTHOR]

The interaction between phenotypic plasticity, e.g. learning, and evolution is an important topic both in Evolutionary Biology and Machine Learning. The evolution of learning is commonly studied in Evolutionary Biology, while the use of an evolutionary process to improve learning is of interest to the field of Machine Learning. This paper takes a different point of view by studying the effect of learning on the evolutionary process, the so-called Baldwin effect. A well-studied result in the literature about the Baldwin effect is that learning affects the speed of convergence of the evolutionary process towards some genetic configuration, which corresponds to the environment-induced plastic response. This paper demonstrates that learning can change the outcome of evolution, i.e., lead to a genetic configuration that does not correspond to the plastic response. Results are obtained both analytically and experimentally by means of an agent-based model of a foraging task, in an environment where the distribution of resources follows seasonal cycles and the foraging success on different resource types is conditioned by trade-offs that can be evolved and learned. This paper attempts to answer a question that has been overlooked: whether learning has an effect on what genotypic traits are evolved, i.e. the selection of a trait that enables a plastic response changes the selection pressure on a different trait, in what could be described as co-evolution between different traits in the same genome. [ABSTRACT FROM AUTHOR]

In light of increasing calls for transparent reporting of research and prevention of detrimental research practices, we conducted a cross-sectional machine-assisted analysis of a representative sample of scientific journals’ instructions to authors (ItAs) across all disciplines. We investigated addressing of 19 topics related to transparency in reporting and research integrity. Only three topics were addressed in more than one third of ItAs: conflicts of interest, plagiarism, and the type of peer review the journal employs. Health and Life Sciences journals, journals published by medium or large publishers, and journals registered in the Directory of Open Access Journals (DOAJ) were more likely to address many of the analysed topics, while Arts & Humanities journals were least likely to do so. Despite the recent calls for transparency and integrity in research, our analysis shows that most scientific journals need to update their ItAs to align them with practices which prevent detrimental research practices and ensure transparent reporting of research. [ABSTRACT FROM AUTHOR]

The mammalian neocortex is subdivided into a series of cortical areas that are functionally and anatomically distinct and are often distinguished in brain sections using histochemical stains and other markers of protein expression. We searched the Allen Mouse Brain Atlas, a database of gene expression, for novel markers of cortical areas. To screen for genes that change expression at area borders, we employed a random forest algorithm and binary region classification. Novel genetic markers were identified for 19 of 39 areas and provide code that quickly and efficiently searches the Allen Mouse Brain Atlas. Our results demonstrate the utility of the random forest algorithm for cortical area classification and we provide code that may be used to facilitate the identification of genetic markers of cortical and subcortical structures and perhaps changes in gene expression in disease states. [ABSTRACT FROM AUTHOR]

In any sport the selection of players for a team is fundamental for its subsequent performance. Many factors condition the selection process from the characteristics of the sport discipline to financial limitations, including a long list of restrictions associated with the environment of the competitions in which the team takes part. All of this makes the process of selecting a roster of players very complex, as it is affected by multiple variables and in many cases marked by a great deal of subjectivity. The purpose of this article was to objectively select the players for a basketball team using an evolutionary algorithm, the Non-dominated Sorting Genetic Algorithm II (NSGA-II) that uses stochastic search methods based on the imitation of natural biological evolution. The sample was composed of the players from the teams competing in the top Spanish basketball league, the Association of Basketball Clubs (ACB). To assess the quality of the solutions obtained, the results were compared with the teams in the ACB playing in the same competition as the players used in the study. The results make it possible to obtain different solutions for composing teams rendering financial resources profitable and taking into account the restrictions of the competition and of each sport management. [ABSTRACT FROM AUTHOR]

We investigate the effectiveness of network attack strategies when the attacker has only imperfect information about the network. While most existing network attack strategies assume complete knowledge about the network, in reality it is difficult to obtain the complete structure of a large-scale complex network. This paper considers two scenarios in which the available network information is imperfect. In one scenario, the network contains link errors (i.e., missing and false links) due to measurement errors, and in the other scenario the target network is so large that only part of the network structure is available from network sampling. Through extensive simulations, we show that particularly in a network with highly skewed degree distribution, network attack strategies are robust against link errors. Even if the network contains 30% false links and missing links, the strategies are just as effective as when the complete network is available. We also show that the attack strategies are far less effective when the network is obtained from random sampling, whereas the detrimental effects of network sampling on network attack strategies are small when using biased sampling strategies such as breadth-first search, depth-first search, and sample edge counts. Moreover, the effectiveness of network attack strategies is examined in the context of network immunization, and the implications of the results are discussed. [ABSTRACT FROM AUTHOR]

Multiple cross-sectional studies have shown that regular complex exercises, which require cognitive demands (e.g., decision making) and various motions, are associated with greater positive effects on executive functions compared to simple exercises. However, the evidence of a single bout of complex exercises is mixed, and investigations on the acute effect of complex exercise using a well-controlled within-subjects research design are few. Therefore, we compared the acute effects of complex exercise on inhibitory functions with those of simple running. Twenty young adults performed three interventions, which were running, badminton, and seated rest as a control condition for 10 min each. During each intervention, oxygen consumption and heart rate were monitored. A Stroop test and a reverse-Stroop test were completed before and after each intervention. The intensities of the badminton and running were equivalent. Badminton significantly improved performance on the Stroop task compared to seated rest; however, running did not enhance performance on the Stroop task relative to seated rest. A single bout of complex exercise elicits a larger benefit to inhibitory function than a single bout of simple exercise. However, the benefit of complex exercise may vary depending on the type of executive functions. [ABSTRACT FROM AUTHOR]

Recent findings have suggested an association between pubic hair grooming and self-reported history of sexually transmitted infection (STI), specifically gonococcal infection (GC), chlamydial infection (CT), or human immunodeficiency virus (HIV). We evaluated the association between self-reported extreme grooming and laboratory-confirmed prevalence of GC/CT. Between April 2017 and April 2018, we enrolled English-speaking, adult, female students at a large, Midwestern university who presented on-campus for STI testing. Participants completed a questionnaire on demographics and sexual and grooming behaviors, which was linked to their GC/CT test results based on nucleic acid amplification testing. We defined extreme grooming as removal of all pubic hair either at least weekly in the past 12 months or ≥6 times in the past 30 days. We used two separate logistic regression models to determine whether odds of GC/CT varied by extreme groomer status for either time interval. In the study sample of 214 women, prevalence of GC/CT was 9.8%. Nearly all participants (98.1%) reported ever grooming; 53.6% were extreme groomers in the past year and 18% in the past month. Extreme grooming was not associated with prevalent GC/CT in the past year (odds ratio [OR] = 0.8; 95% confidence interval [CI]: 0.3–1.9; adjusted OR = 0.7; 95% CI: 0.3–2.0) or in the past month (OR = 0.5; 95% CI: 0.1–2.0; aOR = 0.4; 95% CI: 0.1–1.9). Pubic hair grooming was common among female university students attending for STI testing. Findings do not support pubic hair grooming as an STI risk factor in this population. [ABSTRACT FROM AUTHOR]

Similarity between targets and distracters is a key factor in generating distractibility, and exerts a large detrimental effect on aging. The present EEG study tested the role of a new stimulus dimension in generating distractibility in visual Working Memory (vWM), namely numerical similarity. In a change detection paradigm a varying number of relevant and irrelevant stimuli were presented simultaneously in opposite hemifields. Behavioral results indicated that young participants outperformed older individuals; however, in both groups numerical similarity per se did not modulate performance. At the electrophysiological level, in young participants the Contralateral Delay Activity (CDA, a proxy for item maintenance in vWM) was modulated by the numerosity of the relevant items regardless of numerical similarity. In older participants, the CDA was modulated by target numerosity only in the same numerical condition, where the total number of (relevant and irrelevant) items increased with increasing target numerosities. No effect was present in the dissimilar numerical condition, where the total number of items did not vary substantially across target numerosity. This pattern was suggestive of an age-related effect of the total number of (relevant and irrelevant) items on vWM. The additional analyses on alpha-band lateralization measures support this interpretation by revealing that older adults lacked selective deployment of attentional and vWM resources towards the relevant hemifield. Overall, the results indicate that, while numerical similarity does not modulate distractibility, there is an age-related redistribution of vWM resources across the two visual fields, ultimately leading to a general decrease in task performance of older adults. [ABSTRACT FROM AUTHOR]

When multiple species are vulnerable to a common set of predators, it is advantageous for individuals to recognize information about the environment provided by other species. Eastern gray squirrels (Sciurus carolinensis) and other small mammals have been shown to exploit heterospecific alarm calls as indicators of danger. However, many species–especially birds—emit non-alarm auditory cues such as contact calls when perceived predator threat is low, and such public information may serve as cues of safety to eavesdroppers. We tested the hypothesis that eavesdropping gray squirrels respond to “bird chatter” (contact calls emitted by multiple individuals when not under threat of predation) as a measure of safety. We compared vigilance behavior of free-ranging squirrels in the presence of playbacks of bird chatter vs non-masking ambient background noise lacking chatter after priming them with a playback recording of a red-tailed hawk (Buteo jamaicensis) call. Squirrels responded to the hawk call playbacks by significantly increasing the proportion of time they spent engaged in vigilance behaviors and the number of times they looked up during otherwise non-vigilance behaviors, indicating that they perceived elevated predation threat prior to the playbacks of chatter or ambient noise. Following the hawk playback, squirrels exposed to the chatter treatment engaged in significantly lower levels of vigilance behavior (i.e., standing, freezing, fleeing, looking up) and the decay in vigilance behaviors was more rapid than in squirrels exposed to the ambient noise treatment, suggesting squirrels use information contained in bird chatter as a cue of safety. These findings suggest that eastern gray squirrels eavesdrop on non-alarm auditory cues as indicators of safety and adjust their vigilance level in accordance with the vigilance level of other species that share the same predators. [ABSTRACT FROM AUTHOR]

Learning can be difficult for students due to incorrect prior knowledge, or misconceptions, interfering with the acquisition of new knowledge. Conceptual change refers to the process of replacing such misconceptions with new and accurate knowledge. The factors associated with conceptual change are currently under debate. The present study attempts to replicate previous investigations of how text style and epistemic beliefs impact conceptual change, and extends this work by investigating how those factors differentially facilitate conceptual change within participants. 157 college students completed a two-part, within participants study in which they completed pretests, read passages addressing a misconception, completed posttests, and were assessed on their epistemic beliefs. Text style (expository vs. refutation) and two dimensions of epistemic beliefs (texture and variability) did not directly impact pre-to-posttest changes in performance. However, interactions between text type, texture, and variability were related to changes in performance. [ABSTRACT FROM AUTHOR]

We study in-group favouritism and out-group discrimination in a multiplayer dictator game in a naturally occuring group setting. An allocator divides a large sum of money among three groups of around 20 recipients each and also to themselves. The groups are supporters of two rival political movements in Thailand and politically neutral subjects. The non-rival out-group acts as a reference point and allows us to measure in-group favouritism and out-group discrimination. A treatment with artificial groups serves as a control. We find both in-group favouritism and out-group discrimination among the naturally occurring groups. In artificial groups, favouritism is observed, but not discrimination. Our results suggest that the two behaviours are not driven by the same motive, and only when groups are in conflict that out-group discrimination is likely to occur. [ABSTRACT FROM AUTHOR]