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Objective: To investigate the short- and medium-term (ie, at 1-y follow-up) effects of a hospital-based body weight reduction (BWR) program lasting 3 weeks in severely obese individuals., Design: Longitudinal, clinical intervention study entailing energy-restricted diet, tailored aerobic-strength exercise, psychological counselling and nutritional education during a 3-week period followed by 49 weeks of indirect supervision at home., Subjects: In all, 45 women and 19 men aged 30.2 +/- 7.2 y (mean +/- s.d.) with severe obesity (BMI: 41.3 +/- 4.3 kg/m(2)), classified as weight losers (final < initial weight) and regainers (final> or =initial weight)., Interventions: Body composition, physical performance and cardiovascular risk factors before and after the BWR program and at follow-up., Results: The large majority of the experimental subjects obtained a clinical success after the 1-y period, and the rate was higher in females (n = 37/45, ie, 82.2%) than in males (n = 11/19, ie, 57.9%). At follow-up, weight losers had higher percent fat-free mass, muscle strength, HDL-cholesterol and self-reported physical activity level and lower total cholesterol and glucose levels than weight regainers (P < 0.05-0.01). Males displayed significantly larger fat-free mass losses than females at post-BWR and at follow-up. CONCLUSIONS A 3-week hospital-based integrated BWR program resulted in a high rate of clinical success in severely obese individuals at 1-y follow-up (particularly in females), that was associated with increased levels of self-reported physical activity and improved muscle strength and lipid profile. Further research is needed to establish the long-term effects (ie, at 2-5 y) associated to this treatment.

Acute plasma GH response to prolonged (1 h) near-maximal exercise was studied in 7 elite cyclists (6 males, 1 female; mean age +/- SE: 24.9 +/- 1.4 yr) during a routine training session on an uphill track (length: 22.0 km, average slope: 4.39%) and during a recovery (REC) period of 60 min from the end of exercise. The training session entailed a warming-up (WARM) phase of about 20 min at 63% of individual maximal heart rate (HRmax) followed by a high intensity exercise (HIE) phase of about 60 min at 90-92% of HRmax. GH resting values averaged 0.2 +/- 0.06 ng/ml; average GH concentration attained a maximal value (21.5 +/- 3.3 ng/ml, range: 11.0-38.2 ng/ml) between 20 and 40 min of HIE and significantly decreased thereafter (p=0.01), although exercise intensity was unchanged in the following period (p=0.14). After WARM, GH concentrations were significantly lower than peak values (p=0.05). During REC, GH levels steadily decreased, attaining a value of 2.6 +/- 0.8 ng/ml 60 min after the end of exercise. It was concluded that during prolonged and sustained exercise on-the-field in cyclists, GH value determined at the end of the bout may not correspond to the maximal value, which can be observed after 20 to 40 min of near-maximal exercise.