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Reactions of Zn(NO3)2·6H2O, 2-iodobenzoic acid (2-IBA), and 4-ethyl- or 3-chloropyridine result in the formation of binuclear neutral complexes [Zn2(2-IBA)4L2] (L = 3-ClPy (1), 4-EtPy (2)) whose structures are analyzed by X-ray crystallography. The structure of 2 has specific noncovalent I⋯I interactions.

By the reaction of a rigid π-conjugated H4L linker (5,5′-(1,3,6,8-tetraoxobenzo[lmn][3],[8]phenanthroline-2-7-diyl)bis-1,3-benzenedicarboxylic acid), Cu(NO3)2, and N-donor auxiliary linkers, two new Cu-based coordination polymers (CPs), namely {[Cu(L)0.5(1,4-bib)(H2O)2]·0.5H2O}n (1) and {[Cu(H2L)(4,4′-bibp)(H2O)2]}n (2) {1,4-bib = 1,4-bis(1-imidazolyl)benzene, 4,4′-bibp = 4,4′-bis(imidazolyl)biphenyl} are synthesized under solvothermal conditions and characterized. Furthermore, the protective effect of compounds 1 and 2 on the sepsis mice model is evaluated and the related mechanism is explored. Firstly, the CFU counting assay is performed to detect the bactericidal effect of compounds 1 and 2 in vivo. Then, the ELISA assay is conducted to measure the release of interleukin-1β (IL-1β) and interleukin-6 (IL-6) into the plasma after treatment with the compounds.

The reactions of ReI3, Se, and KCN with Sb2O3 or Bi2O3 at elevated temperature led to the formation of two new tetrahedral clusters with mixed-ligand cluster cores {Re4Se3Sb}7+ and {Re4Se3Bi}7+. Th...

Transition metal carboxylates with O- and N-donor ligands are interesting for their structural features. Seven novel isonicotinamide(inic)-based metal complexes of [Cd(inic)2(L1)2(H2O)2] · 2H2O (1)...

Based on 5-dimethylamino-isophthalic acid (H2dia) and 1,2-bis(4-pyridyl)ethylene (bpe) mixed linkers, a new Cu(II) coordination polymer material, [Cu(dia)(bpe)(H2O)]n (1), has been successfully pre...

By a bifunctional organic ligand 2-(benzimidazol-1-yl)terephthalic acid (H2bitp) featuring both imidazol-carboxylate groups, two new Cu(II)-containing coordination polymers (CPs) with the chemical ...

Two new mixed-ligand coordination polymers based on the Ni(II) ion as the metal center [Ni(L1)(DCTP)] n (1, L1 = 1,1′-(1,4-butanediyl)bis-1H-benzimidazole) and [Ni(L2)(DCTP)] n (2, L2 = 1,4-bis(5,6...

Two new mixed-ligand coordination polymers (CPs) with the chemical formulae of [Co(L)(phen)]n (1, phen = 1,10-phenanthroline and [Co(L)(4,4′-bipy)4·2H2O]n (2, 4,4′-bipy = 4,4′-bipyridine) have been...

By applying the mixed-ligand method, a new Co(II)-based coordination polymer with the chemical formula of {[Co2L(4,4′-bipy)0.5(H2O)] · 0.25H2O}n (1) have been successfully prepared by reaction of C...

The Co2+–triglycine–L-histidine system is studied in an aqueous solution at Т = 298.15 K (KNO3) via potentiometry and calorimetry. The formation of mixed-ligand CoL2Y− complex is established, and the standard thermodynamic characteristics (ΔrH°, ΔrG°, ΔrS°) of the complexation reaction are determined. A structure is proposed for this complex.

We report the synthesis of two isoreticular, mixed-ligand metal–organic frameworks (MOFs), [Cd(μ2-mia)(μ2-bpe)]n·n(DMF)0.5·n(H2O)0.5 (1) and [Cd(μ2-nia)(μ2-bpee)]n·nDMF (2), where mia = 5-methoxyis...

In the current study, two new transition metal-organic coordination polymers (CPs) with the chemical formula of [Cu(L)(OBA)(H2O)]n (1) and [Co(L)(OBA)]n (2) (H2OBA = 4,4(L)(OBA)]dy, two new traL = ...

Mixed-ligand Cu(I) complexes have attracted attention as alternatives to the noble- and/or rare-metal complexes, because of their remarkable photofunctions. To develop mixed-ligand Cu(I) complexes with rich photofunctions, an investigation of a suitable combination of ligands has captured more and more research interests. Herein, we report the first examples of emissive heteroleptic diphosphine-disulfide Cu(I) complexes combined with diphosphine ligands. The systematic study using a series of diphosphine ligands revealed that large π-conjugated bridging moieties between the two P atoms in the diphosphine ligands result in higher light-emission performance. When the diphosphine ligand was (

Two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L1)(bdc)](H2O)}n (1, L1 = 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene, H2bdc = terephthalic acid) and {[Co(L2)(bdc...

In the current study, a novel mixed-ligand coordination polymer, {[Co(L)(dpe)]·(ClO4)} (1) (H2LCl = 3-carboxy-1-(3-carboxybenzyl)pyridin-1-ium, dpe = (E)-1,2-di(pyridin-4-yl)ethene), was synthesize...

Two mixed-ligand coordination polymers with the chemical formulae {[Cu3(Hdpc)2(tib)2(H2O)2]·2H2O)}n (1, H3dpc = 2,6-di(4-carboxylphenyl)pyridine-4-carboxylic acid, tib = 1,3,5-tris(1-imidazolyl)benzene)) and [Cu(trans-chda)2(bimb)2·2H2O]n (2, H2chda = 1,4-cyclohexane(dicarboxylic)acid, bimb = 1,4-bis((1H-1,2,4-triazol-1-yl)methyl)benzene) are successfully prepared by the reaction of Cu(NO3)2·3H2O with different O-donor carboxylic acid and N-donor co-ligands under the solvothermal conditions. Furthermore, the treatment effect of the two compounds on the acute pancreatitis is evaluated in the biological experiment. Firstly, RT-PCR is performed to measure the relative expression level of the key genes of E. coli. Moreover, the inflammatory levels of the patients are evaluated by the ELISA detection of inflammatory cytokines, IL-1β, and TNF-α.

In the current study, two new Cu(II)-containing coordination polymers (CPs) with the chemical formula of {[Cu2(Py2TTz)(2-CH3-BDC)2]·2(DMF)·3(H2O)}n (1, 2-CH3-H2BDC = 2-methyl-1,4-benzenedicarboxyli...

Two Co(II)-containing coordination polymers, {Co(TDC)(TPB)0.5·H2O}n (1) and {[Co2(2,6-NDC)2(TPB)]·MeCN·3H2O}n (2) (TPB = 1,2,4,5-tetra(4-pyridyl)benzene, H2TDC = 2,5-thiophenedicarboxylic acid, 2,6...

A new 3D Cd(II) coordination polymer, {[Cd2(btc)(HL)(H2O)]·3H2O}n (1) (H2L= 3-(1H-pyrazol-4-yl)-5-(pyridin-2-yl)-1, 2, 4-triazole; H3btc = 1,3,5-benzenetricarboxylic acid), has been synthesized by ...

By using a mixed-ligand approach, two new coordination polymers with the chemical formula of {[Zn(L)(ip)·H2O]8}n (1, H2ip = isophthalic acid and L = 1,1’-(2-methylpropane-1,3-diyl)bis(1H-benzo[d]im...

A new metal–organic framework was prepared based on a mixed ligand system of the designed nitrogen-rich 3,6-bis(2-methylimidazole)pyrimidine (b2mpm) and benzophenone 4,4′-dicarboxylic acid (H2bpndc...

The reaction of dimethyltin(IV) dichloride (DMT) with homopiperazine (HPIP) was studied. The equilibria of the complexes formed in solution were investigated. The complexes detected are of 1:1 stoi...

Solvothermal reactions of Co(OAc)2·4H2O or Ni(NO3)2·3H2O with 1,4-bis(benzimidazol-1-ylmethyl)-benzene (bmib) ligand and 1,4-terephthalic acid (H2bdc) afforded two 2-dimensional coordination polyme...

Hydroxypyridinone and hydroxypyranone are known to be used for the treatment of iron overload by chelation therapy for a long time. Both the ligands have their own side effects when used as medicines. In the present study homo and mixed ligand complexes of both the ligands with iron were prepared and characterized by UV-visible spectrophotometry, Potentiometric study, IR spectroscopy, SEM/EDX and XRD. Overlay spectra obtained from UV-visible spectroscopy of our studied system show the formation of different types of species and confirm that mixed ligand complex is different from the other two systems. Potentiometric titration curves of homo and mixed ligand complexes show the formation of different types of species at different pH and confirm the formation of mixed ligand complex. The comparative results of SEM images of these systems show different surface topologies and hence conform to the formation of mixed ligand complex.

By employment of a mixed-ligand strategy, two coordination polymers were synthesized via the hydrothermal approach utilizing two positionally isomeric carboxylic acid ligands 1,4-benzenedicarboxyli...

Two new mixed-ligand coordination polymers with the chemical formulae of {[Zn3(nbta)2(bpfp)2(H2O)2](H2O)2}n (1, H3nbta = 5-nitro-1,2,3-benzenetricarboxylic acid, bpfp = bis(4-pyridylformyl)piperazi...

A systematic investigation into the reactions of Cd(NO3)2·4H2O with o- and p-phenylenediacetic acid within the presence of the semi-rigid 1,4-bis(imidazol-1-ylmethyl)benzene (bimb) co-ligands under...

In this study, two new mixed-ligand coordination polymers (CPs) {[Cd6(nbta)3(bimb)4(H2O)](H2O)3}n (1, bimb = 4,4′-bis((1H-imidazol-1-yl)methyl)−1,1′-biphenyl) and [Co3(bib)2(nbta)2]n (2, bib = 1,4-...

In the current study, two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L1)0.5(oba)·DMF]·DMF·H2O} (1, L1 = N,N′-bis(4-pyridylmethyl)-naphthalene diimide, H2oba = 4,4′-ox...

The Schiff base ligand L is developed from furan-2-carboxaldehyde, 4-aminoantipyrine together with 2-aminothiazole. The mixed ligand complexes are developed from the condensation of above Schiff base ligand L, 1,10-phenanthroline as well as metal(II) acetates of Co(II), Ni(II), Cu(II), and Zn(II). The newly produced compounds were characterized using molar conductance, elemental analysis, XRD, mass, UV-Vis, 1H NMR as well as IR spectral techniques. The X band ESR of [CuLphen] complex was recorded at 300 and 77 K. Geometry and Mulliken charge distribution of the L were studied using Density functional theory (DFT). In vitro biological analysis of L and its [CoLphen], [NiLphen], [CuLphen] as well as [ZnLphen] complexes were studied against bacterial variety such as Pseudomonas aeruginosa, Escherichia coli as well as Staphylococcus aureus. The fungal varieties include Aspergillus niger and Candida albicans. The potent DNA cleavage activities of L as well as its complexes were evaluated.

Mixed ligand complexes of copper(II) and nickel(II) with glycine (Gly) and histidine (His) have been studied in aqueous solution using calorimetric, potentiometric and spectrophotometric data at 298.15 K and the ionic strength of I = 0.5 mol·L–1 (KNO3). The thermodynamic parameters of formation of various mixed complexes have been determined. The probable coordination modes of amino acid residues in mixed ligand complexes is discussed.

Advancement of the synthesis and control of the self-assembly process of new high-nucleus silver clusters with desired structures is important for both the material sciences and the many applications. Herein, three new silver clusters, 20-, 22-, and 8-nucleus, based on alkynyl ligands were constructed and their structures were confirmed by single-crystal X-ray diffraction, powder X-ray diffraction, elemental analyses, and Fourier-transform infrared spectroscopy (FT-IR). For the first time, the trivalent tetrahedron anion of AsO

In this work, by employment of a rod-like ligand 4,4′-bis(imidazol-1-yl)-biphenyl (bibp) as the building block, a new Zn(II)-containing coordination polymer with the chemical formula of {[Zn2(HCO2)...

New mixed ligand complexes of nickel(II) were synthesized by using dibasic H/5-bromo-/5-chloro-/4-hydroxy-2-hydroxybenzophenone-thiosemicarbazones (L1–4H2) and [Ni(PPh3)2Cl2]. The ligands and complexes were characterized by cyclic voltammetry, infrared, 1H and 31P NMR spectroscopy techniques. Crystallographic analyses of the 5-bromo-substituted (2) and 5-chloro-substituted (3) complexes as representatives were performed and so confirmed the ONS chelate structure and presence of PPh3 as co-ligand in the complexes. To reveal the antioxidant properties of the compounds, TEAC values (by CUPRAC method) were determined along with free radical-scavenging activity (by DPPH method). The compounds bearing 4-hydroxy substituent, L4H2 and complex 4 were the most effective compounds. The relationship between structure and antioxidant capacity in the context of benzophenone substituents and nickel(II) center was evaluated. Electrochemical results revealed that all complexes displayed metal-centered and ligand-centered redox processes. The antioxidant capacities of complexes were well correlated to electrochemical parameters.

A novel Co(II)-based metal-organic framework (MOF) {[Co2(TCPP)(BPY)](DMF)3}n (1) with a pillared structure based on 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine (H4TCPP) and 4,4'-bipyridine (BPY) is designed and synthesized via the solvothermal reaction. Furthermore, a green-hand grinding technique is implemented to reduce the particle size of complex 1 to generate nanoscale 1 (denoted as nano-1 hereafter). After the construction of the acute cerebral infarction animal model, the infarct area of the brain is measured after 2 weeks of treatment with the compound. Then, ELISA is performed to detect the content of hs-CRP and IL-1b and TNF-a in the serum.

In the current study, two new mixed-ligand coordination polymers with the chemical formulae of {[Cu(oba)(4-bpdb)]·CH3OH}n (1) and {[Co3(oba)3(4-bpdb)(DMF)2]·4H2O}n (2) (H2oba = 4,4'-oxybis-benzoate, 4-bpdb = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene) are synthesized under solvothermal conditions. Both structures are analyzed by single crystal X-ray diffraction along with the elemental analysis. Their prevention activity on the acute kidney injury in patients with acute cerebral hemorrhage is evaluated and the protentional mechanism is revealed. Firstly, the Nagl content in urine is measured. Secondly, the inflammatory response in glomerular epithelial cells is detected by real-time RT-PCR.

A reaction of the N-donor ligand 1,3-di(1H-imidazol-1-yl)benzene (dimb) with Co(NO3)2·6H2O and the V-shaped carboxylate ligand biphenyl-3,4',5-tricarboxylic acid (H3bpt) under hydro- or solvothermal conditions yields two new Co(II)-based coordination polymers with the chemical formulas {Co3(dimb)2(bpt)2(H2O)4]}n (1) and [Co2(dimb)2(Hbpt)2]·H2O (2). Furthermore, the treatment effect of compounds 1 and 2 against cardiac arrest induced by anesthesia is evaluated. Firstly, ELISA is used to detect the content of cardiac troponin T and B brain natriuretic peptide after treatment with the compounds. Moreover, RT-PCR is conducted and the relative expression level of Sirt1 in the rat myocardial tissue is measured.

In this study, we report the synthesis and structural characterization of two new Co(II) and Cu(II) containing coordination polymers {[Co2(btc)(mbtz)2]·7H2O}n (1), [Cu2(btc)(mbtz)2]n (2) by using t...

The solvothermal reaction of Cd(NO3)2·4H2O with different donor ligands afforded two new Cd(II)-based coordination polymers [Cd(Hcia)(btz)]n (1, H3cia = 5-(4-carboxyphenoxy)isophthalic acid, btz = ...

Mixed ligand approach has been successfully applied to design coordination polymers with diversiform architectures. In this study, two novel mixed-ligand Zn(II)-based coordination polymers ...

In this work, a new Ni(II)-based coordination polymer (CP) with the chemical formula of {[(Ni)2(L1)(L2)(H2O)2](DMF)2}n (1, H4L1 = 5-((3,5-dicarboxybenzyl)oxy)isophthalic acid, L2 = 2,4,6-tr...

A series of mixed-ligand Cu(II) complexes of the type: (i) [Cu(l-pro)(diimine)(H2O)n](ClO4) (n = 0 or 1), where l-pro is l-proline and diimine is 2,2′-bipyridine (bpy; 1), (ii) 4,4′-dimethy...

Tris(glycinato)Mn(III) and its mixed ligand complexes with azido-, thiocyanato-, chloro- and bromo- groups have been synthesized and characterized by UV–Vis spectrophotometry, IR spectropho...

Initially, a novel series of mixed ligand Pd(II) complexes of 2H[1,4]benzothiazin-3(4H)-one (Hbto) and diamine or phosphine ligands were successfully prepared with yields of 61 to 92%. The treatment of Na2PdCl4 with Hbto in acetone with 1:2 Pd to Hbto ratio affords cis-[PdCl2(Hbto)2] (1) that delivers an appropriate entry into mixed-ligand Hbto complexes. The complex (1) was used as a precursor for preparation the complexes of the type [Pd(Hbto)2(κ2-diamine)]Cl2; (diamine = en (2a), bipy (2b), phen (2c)) and [Pd(Hbto)2(κ2-diphosphine)]Cl2; (diphosphine = dppm (3a), dppe (3b), dppp (3c), dppf (3d)). Likewise, the mono phosphine (PPh3) was used to prepare the contrast complex with complex (1), however, to dissipate the suspicion that define complex [Pd(Hbto)2(PPh3)2]Cl2 is present in the cis or trans structure, two methods were used to prepare this complex, both of which demonstrated that the cis is the preferred structure for the complex [Pd(Hbto)2(PPh3)2]Cl2 (4). For all as-prepared complexes, the characterization techniques (molar conductivity, IR, 1H-, 13C-{1H}, 31P-{1H}NMR and elemental analyses) prove that the Hbto links to Pd(II) in a mono-dentate fashion through the exocyclic oxygen atom. To benefit from the complexes prepared, some as-prepared complexes (1), (2b) and (4) have been evaluated for their H2 storage at 77 K after measuring the N2 adsorption/desorption isotherms in order to get some information about BET surface areas of the samples. The results demonstrate that the selected prepared complexes were all able of storing the H2 and among the complexes (1), (2b) and (4), (2b) was the best one and was able to store 5.4 wt% of H2 under 70 bar and 77 K.

Mixed-ligand polymeric and binuclear silver(I) complexes with azaheterocyclic ligands and the closo-decaborate anion of the composition [Ag2L[B10H10]]n and [Ag2L2[B10H10]] (L = bipy, bpa, and phen) are synthesized and studied by IR-spectroscopy and X-ray powder diffraction. The complexes are prepared by the reaction between [Ag2[B10H10]] and ligand L in organic solvents. It is found that polymeric and binuclear complexes are selectively formed depending on the solvent used. When the reaction proceeds in acetonitrile, polymeric complexes are isolated. When DMF is used, binuclear complexes are formed which explains by the complete dissociation of the starting [Ag2[B10H10]] complex. The structures of [Ag2(bipy)[B10H10]]n and [Ag2(bpa)2[B10H10]]·DMF are determined by X-ray diffraction.

The Cu2+–triglycine–L-histidine system was studied by potentiometry and calorimetry in an aqueous solution at T = 298.15 K (KNO3). Mixed-ligand CuLY and CuLHY+ complexes formed in the system. The standard thermodynamic characteristics (ΔrH°, ΔrG°, ΔrS°) of their formation reactions were determined. The possible structures of the mixed-ligand complexes were given.

The last decade has witnessed tremendous advances in the design of anticancer gold complexes containing tertiary phosphines, a class of ligands that have significantly contributed to the development of metal complexes owing to their stabilizing effect. The promising in vitro antiproliferative properties of the phosphine-containing organogold compound auranofin [1-(thio-kS)-2,3,4,6-tetra-O-acetyl-β- d -glucopyranose](triethylphosphine-kP)gold(I), originally used to treat rheumatoid arthritis, inspired the extensive application of monodentate phosphines in the development of anticancer gold complexes. Meanwhile, the use of diphosphine ligands promoted advances in the preparation of chelated gold complexes as well as mixed-metal and mixed-ligand complexes that have superior anticancer activity. The present report summarizes the current state of knowledge of diphosphine ligands in the development of anticancer gold complexes, and explores challenges and opportunities in designing gold-containing mixed-metal and mixed-ligand complexes that have anticancer action.

Mixed ligand complexes [Cu(phen)(Lap)2] (1) and [Co(dppeO)(Lap)2] (2) were synthesized from the reaction of lapachol (Lap) with [Cu(phen)Cl2] or [Co(dppe)Cl2] in the presence of Et3N. Complexes (1) and (2) were fully characterized by X-ray crystallography, elemental analyses, and infrared spectroscopy. Antiproliferative activities of complexes (1) and (2) against several tumor cell lines were also determined alongside those of [Cu(Lap)2(EtOH)2] (3) and [Co(Lap)2(EtOH)2] (4).