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Click here to view the Letter to the Editor by Pineton de Chambrun et al. [ABSTRACT FROM AUTHOR]

Dear Editor, Coronavirus disease 2019 (COVID-19) is associated with both severe systemic inflammation and a prothrombotic state, as reflected by significant increases in fibrinogen and D-dimers levels that have been associated with poor prognosis [1] and high rates of severe pulmonary embolism [2]. We herein describe the profile of aPLA positivity in a series of 25 critically ill patients with severe COVID-19 infection. Most patients had positive LA and double aPLA positivity which are associated with a high risk of venous and arterial thrombosis in antiphospholipid syndrome patients [4]. As we also recently noticed unexplained lengthening of activated partial thromboplastin time (aPTT) in some critically ill COVID-19 patients, we explored our patients for aPLA positivity. [Extracted from the article]