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Solvent-mediated chemical reactions, nucleation, and phase transformation are common approaches to traditional batch crystallization of active pharmaceutical ingredients (APIs), but solvents can affect API solubility, polymorphism, and crystal properties. To [...]

In Part 1 of this article, which appeared in the March 2010 issue of Pharmaceutical Technology, the authors described their approach for constructuring form spaces for carbamazepine, cimetidine, and phenylbutazone [...]

In Part I of this article, the authors discuss their approach for constructing form spaces for the nonionizabie active pharmaceutical ingredients carbamazepine, cimetidine, and phenylbutazone by initial solvent screening of [...]

Many processes such as spherical crystallization, microemulsions, and organic nanocrystal fabrication require combinations of several solvents. A solution's composition ratio at the time of nucleation greatly influences the solubility, polymorphism, [...]

Many processes such as spherical crystallization, microemulsions, and organic nanocrystal fabrication require combinations of several solvents. A solution's composition ratio at the time of nucleation greatly influences the solubility, polymorphism, [...]

Crystallization is often performed in solvents or mixtures of solvents. Recrystallization by solvent screening is particularly important for the pharmaceutical industry. The authors propose extending initial solvent screening for a [...]

The racemic compound (R, S)-(±)-ibuprofen is a popular and well understood active pharmaceutical ingredient, but it has several disadvantageous formulation properties such as poor solubility, low melting point, and potential [...]

Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Solubility curves were constructed, and solubility at 25 °C [...]

The indentation-size effect forms the basis of the relationships connecting average particle size ([r.sub.0.5])with densification, tensile strength, and hardness of one-component tableting systems. Those structure-property relationships also have been verified [...]

Polymorph farming on a chip is a promising approach for rapid polymorph discovery. It transforms the crystallization--crystal isolation--characterization process into one time-efficient step. Crystals grown and harvested by this method [...]

The control of particle size often requires insight into the operating conditions of drying and dryer selection. In this article, the authors have derived three simple functions for a pan [...]

In this article, the authors discuss the development of a rapid screening technology based on the integration of spin-on and optical microscopy. This method was tested on four solid dispersion [...]