1. The effect of an in situ-produced oil shale processing water on metabolism.
- Author
-
Nelson KF, North DS, Payne GR, Anderson AD, Poulson RE, and Farrier DS
- Subjects
- Animals, Cytochrome P-450 Enzyme System metabolism, Ethylmorphine-N-Demethylase metabolism, Half-Life, Hexobarbital metabolism, In Vitro Techniques, Liver metabolism, Male, Proteins metabolism, Rats, Zoxazolamine metabolism, Industrial Waste, Metabolism drug effects, Petroleum, Water Pollutants pharmacology, Water Pollutants, Chemical pharmacology
- Abstract
The effects of in situ-produced oil shale retort water on the metabolism of various substrates was studied both in vivo and in vitro. The induction observed in rats was classified as Type I due to an increase in metabolism of hexobarbital and ethylmorphine without subsequent increases in zoxazolamine metabolism. The maximal absorption of the cytochrome-P450-CO complex was observed to be 450 millimicron, also consistent with Type I inducers. Cytochrome P-450 levels were also significantly increased over controls.
- Published
- 1978
- Full Text
- View/download PDF