1. Peroxisomal hydrogen peroxide signaling: A new chapter in intracellular communication research.
- Author
-
Fransen M and Lismont C
- Subjects
- Oxidation-Reduction, Signal Transduction, Cell Communication, Hydrogen Peroxide metabolism, Peroxisomes metabolism
- Abstract
Hydrogen peroxide (H
2 O2 ), a natural metabolite commonly found in aerobic organisms, plays a crucial role in numerous cellular signaling processes. One of the key organelles involved in the cell's metabolism of H2 O2 is the peroxisome. In this review, we first provide a concise overview of the current understanding of H2 O2 as a molecular messenger in thiol redox signaling, along with the role of peroxisomes as guardians and modulators of cellular H2 O2 balance. Next, we direct our focus toward the recently identified primary protein targets of H2 O2 originating from peroxisomes, emphasizing their importance in unraveling the complex interplay between peroxisomal H2 O2 and cell signaling. We specifically focus on three areas: signaling through peroxiredoxin redox relay complexes, calcium signaling, and phospho-signaling. Finally, we highlight key research directions that warrant further investigation to enhance our comprehension of the molecular and biochemical mechanisms linking alterations in peroxisomal H2 O2 metabolism with disease., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
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