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3 results on '"Marchitelli E"'

1. Biological effects of a software-controlled voltage pulse generator (PhyBack PBK-2C) on the release of vascular endothelial growth factor (VEGF).

Author

Ferroni P, Roselli M, Guadagni F, Martini F, Mariotti S, Marchitelli E, and Cipriani C

Subjects
Aged, Algorithms, Cytokines metabolism, E-Selectin blood, Electric Stimulation instrumentation, Female, Humans, Italy, Kinetics, Male, Middle Aged, Nitric Oxide biosynthesis, Peripheral Vascular Diseases physiopathology, Pilot Projects, Solubility, Tumor Necrosis Factor-alpha metabolism, Vascular Endothelial Growth Factor A blood, Electric Stimulation methods, Equipment and Supplies, Peripheral Vascular Diseases therapy, Software, Vascular Endothelial Growth Factor A metabolism
Abstract

Background: Electrical stimulation (ES) may induce vascular permeability and physiological angiogenesis. ES of rat muscles significantly increases the microvessel density and vascular endothelial growth factor (VEGF) protein levels. Thus, a pilot study was designed to analyze the effects of low-voltage electric impulses on VEGF levels in patients with dystrophic ulcers., Materials and Methods: Circulating VEGF levels were analyzed in 9 patients undergoing an ES session with low voltage software-controlled impulses applied through topical transducers (1-9 micros width, 1-420-Hz frequency and 30-120 V strength-100 microA max)., Results: The session was accompanied by a peak of circulating VEGF (3-10 min from start) in all 9 patients, which was preceded by a rise of TNF-alpha (2-min) and was independently associated with soluble E-selectin levels. Nitric oxide generation was significantly improved on the day after treatment. No hemostatic activation or sustained inflammatory reaction were observed., Conclusion: ES may represent a safe method for augmenting VEGF-mediated vascular protection, either directly or by induction of NO.

Published
2005

2. Prevention of serious vascular events by aspirin amongst patients with peripheral arterial disease: randomized, double-blind trial

Author

Fabris, F., Pilger, E., Pabst, E., Kostner, G., Wautrecht, J. C., Baitsch, G., Breddin, K., Diehm, C., Podhaisky, H., Taute, B. M., Diamantoupolos, E. J., Aimar, T., Alari, G., Albano, S., Altamura, N., Arosio, E., Bortolon, M., Caccia, R., Carotta, M., Carzaniga, G., Catalano, M., Contini, P., Difolca, A., Dore, M., Falaschi, F., Franchini, B., Frare, C., Frascisco, M., Giansante, C., Giona, E., Giubbolini, M., Lucarelli, F., Marchitelli, E., Marcialis, M. R., Martignoni, A., Melillo, E., Minola, M., Monetti, D., Nenci, G., Paolicelli, M., Pasqualini, L., Perilli, E., Pettina, G., Poli, L., Radicchia, S., Rossi, M., Scandale, G., Scondotto, G., Sergi, D., Setacci, C., Spada, S., Todini, A. R., Vaudo, G., Verlato, F., Visona, A., Zannoni, M., Bielawiec, M., Jawien, A., Meissner, A., Michalak, J., Nizankowski, R., Wandzilak, M., Avram, J. A., Avram, R., Hancu, N., Marian, A., Marian, I., Murariu, M., Negrisanu, G., Olinic, D., Olinic, N., Trambitas, R., Veresiu, I., Victoria, I., Kozak, M., Mavri, A., Bahi, J. S., Bahi, P. S., Brunkwall, J., and Gallino, A.

Subjects
Male, medicine.medical_specialty, Settore MED/09 - Medicina Interna, Placebo, law.invention, Double-Blind Method, Randomized controlled trial, Ischemia, law, Internal medicine, Internal Medicine, medicine, Humans, Myocardial infarction, Stroke, Aged, Angiology, Peripheral Vascular Diseases, Leg, Aspirin, Vascular disease, business.industry, Antioxidant vitamins, Peripheral arterial disease, Prevention, medicine.disease, Surgery, Clinical trial, Treatment Outcome, Female, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract

OBJECTIVE: To assess the prophylactic efficacy of aspirin and a high-dose antioxidant vitamin combination in patients with peripheral arterial disease (PAD) in terms of reduction of the risk of a first vascular event (myocardial infarction, stroke, vascular death) and critical limb ischaemia. DESIGN: Randomized, placebo-controlled, double-blind clinical trial with 2 x 2 factorial design. SETTING: Thirty-seven European angiology/vascular medicine units. SUBJECTS: A total of 366 outpatients with stage I-II PAD documented by angiography or ultrasound, with ankle/brachial index

Published
2007
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3. Biological effects of a software-controlled voltage pulse generator (PhyBack PBK-2C) on the release of vascular endothelial growth factor (VEGF)

Author

Patrizia Ferroni, Roselli, M., Guadagni, F., Martini, F., Mariotti, S., Marchitelli, E., and Cipriani, C.

Subjects
Male, Vascular Endothelial Growth Factor A, Peripheral Vascular Diseases, Tumor Necrosis Factor-alpha, Settore MED/06 - Oncologia Medica, Pilot Projects, Middle Aged, Nitric Oxide, Electric Stimulation, Kinetics, Solubility, Italy, Equipment and Supplies, Humans, Cytokines, Female, Software, Aged, E-Selectin, Algorithms

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