Search

Enzyme catalysis in reactors for industrial applications usually require an external intervention of the species involved in the chemical reactions. We analyze the most elementary open enzyme catalysis with competitive inhibition where a time-dependent inflow of substrate and inhibitor supplies is modeled by almost periodic functions. We prove global stability of an almost periodic solution for the non-autonomous dynamical system arising from the mass-law action. This predicts a well behaved situation in which the reactor oscillates with global stability. This is a first case study in the path toward broader global stability results regarding intraspecific and monotone open reaction networks. [ABSTRACT FROM AUTHOR]

We study first order differential equations with continuous almost periodic time dependence. We propose existence and global stability criteria of almost periodic solutions. Our results are specially useful in the study of one species population dynamics, such as logistic models with almost periodic parameters. Almost periodic time dependence also provides an explanation for oscillatory solutions in models of hematopoiesis disease dynamics. [ABSTRACT FROM AUTHOR]

Oscillations appear in all levels of biological organization. Oscillatory phenomena do not always possess a simple periodic nature. In this work, we analyze a gene transcriptional network in which we assume an almost periodic input that regulates gene. We use an almost periodic input k (t) since a periodic one is very restrictive. We show that the almost periodic model proposed has a unique almost periodic attractor. Numerical simulations show that the retroactivity is highly affected when an almost periodic input is used in an upstream system that is interconnected to a downstream system. By comparison of the solutions of the model, we can conclude that when the amount of protein bound to the promoter is modeled by either a periodic function or an almost periodic one, which is denoted by k (t) , the amount of protein concentration X can be underestimated or overestimated depending on if k (t) is modeling by a periodic or an almost periodic function. These estimation errors can lead to an error in the quantification of retroactivity which in turn can alter the coordination between an upstream system and a downstream one. [ABSTRACT FROM AUTHOR]

We incorporate almost periodic functions in a mosquito model to take into account a loss of synchronicity in the population dynamics of mosquitoes due to climate change. The model takes into account the skip oviposition strategy that is associated with the mosquitoes that are vectors of infectious diseases as dengue, malaria and leishmaniasis. We prove existence and uniqueness of a stable almost periodic solution for some conditions over the parameters of the model. Numerical simulations are performed using values estimated for the life cycle of Aedes albopictus gathered in literature. The results show that the vector population can be underestimated or overestimated if an almost periodic dynamics is approximated by a periodic dynamics. Therefore, using an almost seasonal model can be more adequate to design breeding habitat-targeted mosquito control strategies when seasonal drivers are modeled since climate-mediated shifts can induce a loss of periodicity in environmental drivers. [ABSTRACT FROM AUTHOR]

Modeling of multi-layered cell cultures (MCC) assume flat geometry in a 3D tumor growth model. Some results available in the time-dependent framework assume a periodic nutrient supply ф(t)/. Our aim is to generalize such considerations. Namely, we show that a stable oscillating tumor growth arises in the long term, whenever the mean value of the almost periodic nutrient supply ф surpasses certain threshold level, ф > σ. Meanwhile, a vanishing tumor is predicted in the complementary case, ф ≤σ. [ABSTRACT FROM AUTHOR]

In this work, we study models of enzyme-catalysed reactions which include an almost periodic substrate input. The main results are the existence, uniqueness and global stability of an almost periodic solution of the system under some restrictions on the parameters. [ABSTRACT FROM AUTHOR]