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Objective: Myocardial first-pass perfusion imaging with MRI is well-established clinically. However, it is potentially weakened by limited myocardial coverage compared to nuclear medicine. Clinical evaluations of whole-heart MRI perfusion by 3D methods, while promising, have to date had the limit of breathhold requirements at stress. This work aims to develop a new free-breathing 3D myocardial perfusion method, and to test its performance in a small patient population. Methods: This work required tolerance to respiratory motion for stress investigations, and therefore employed a "stack-of-stars" hybrid Cartesian-radial MRI acquisition method. The MRI sequence was highly optimised for rapid acquisition and combined with a compressed sensing reconstruction. Stress and rest datasets were acquired in four healthy volunteers, and in six patients with coronary artery disease (CAD), which were compared against clinical reference information. Results: This free-breathing method produced datasets that appeared consistent with clinical reference data in detecting moderate-to-strong induced perfusion abnormalities. However, the majority of the mild defects identified clinically were not detected by the method, potentially due to the presence of transient myocardial artefacts present in the images. Discussion: The feasibility of detecting CAD using this 3D first-pass perfusion sequence during free-breathing is demonstrated. Good agreement on typical moderate-to-strong CAD cases is promising, however, questions still remain on the sensitivity of the technique to milder cases. [ABSTRACT FROM AUTHOR]

Cardiovascular events account for half of the deaths related to non-cardiac surgery. Identification of a patient's risk and perioperative management appropriate to that risk is important to optimize the clinical outcome of surgery. Key concepts of preoperative cardiac risk assessment are contained within American and European guidelines. Risk indices stratify patients according to clinical and surgery-specific predictors. The most widely used is the Lee index; however, all have limitations. Patients at intermediate and high risk following risk index stratification and assessment of functional capacity require further non-invasive assessment to detect myocardial ischaemia using, for instance, exercise electrocardiography, myocardial perfusion scintigraphy, or stress echocardiography. It can be difficult, however, to decide which technique and predictor is most effective and local practice differs. Invasive coronary angiography is not recommended unless it would be performed in the absence of surgery. Appropriate pain management should be considered in all patients and beta-blockade may improve the outcome in intermediate- and high-risk patients. Identifying patients with risk factors or previously undiagnosed coronary artery disease enables the preoperative cardiac risk assessment to guide long-term treatment. [ABSTRACT FROM AUTHOR]

In this article, the authors discuss the technical innovations and development of clinical applications to be made in Myocardial Perfusion Scintigraphy (MPS). The authors inform about the introduction of different new types of cardiac footprint cameras which can translate photon energy into electronic pulses. The authors further discuss the advances made in the clinical applications of MPS including the use of ventricular dyssynchrony. INSET: High-risk imaging variables.

The purpose of this study was to evaluate the feasibility and accuracy of combined coronary and perfusion cardiovascular magnetic resonance (CMR) in the assessment of coronary artery stenosis. Thirty-five consecutive patients (27 men, eight women, age range 34–81 years), undergoing cardiac catheterization, were assessed with 3D coronary CMR and rest-stress perfusion CMR. Significant coronary stenosis was determined by vessel narrowing or signal loss with coronary CMR, and by abnormal contrast enhancement with perfusion CMR. Coronary artery diameter stenosis greater than 50% was considered significant with conventional cardiac catheterization. Seventeen patients had significant coronary artery disease, and in these there were 35 significant stenoses on cardiac catheterization. All left main stem arteries were normal on both cardiac catheterization and coronary CMR. For the diagnosis of coronary artery stenosis, coronary CMR had a sensitivity of 92% for the left anterior descending artery (LAD), 79% for the right coronary artery (RCA), but only 13% for the circumflex coronary artery (LCX). Perfusion CMR had corresponding sensitivities of 69%, 86%, and 63%, respectively. For all arteries the accuracies for coronary and perfusion CMR were 67% and 72%, respectively. Combining coronary and perfusion CMR improved the accuracy to 77%. These data demonstrate that in patients with suspected coronary artery disease, combined coronary and perfusion CMR is feasible, increases the accuracy of detection of significant coronary stenosis, and offers the possibility of combined anatomical and hemodynamic assessment of coronary artery stenosis. [ABSTRACT FROM AUTHOR]

An abstract of the article "Cardiac magnetic resonance perfusion imaging and the effects of single intravenous cannulation with the Octopus bionector," by Heiko E. Kindler and colleagues is presented.