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Your search keyword '"Lindell, G."' showing total 7 results
Start Over Author "Lindell, G." Topic peptic ulcer
7 results on '"Lindell, G."'

1. Bleeding peptic ulcer - time trends in incidence, treatment and mortality in Sweden.

Author

Sadic J, Borgström A, Manjer J, Toth E, and Lindell G

Subjects
Adult, Age Distribution, Aged, Aged, 80 and over, Cohort Studies, Female, Helicobacter Infections complications, Humans, Incidence, Male, Middle Aged, Peptic Ulcer mortality, Peptic Ulcer therapy, Peptic Ulcer Hemorrhage mortality, Peptic Ulcer Hemorrhage therapy, Risk Factors, Sex Distribution, Sweden epidemiology, Time Factors, Treatment Outcome, Anti-Ulcer Agents therapeutic use, Helicobacter Infections drug therapy, Helicobacter pylori isolation & purification, Peptic Ulcer epidemiology, Peptic Ulcer Hemorrhage epidemiology
Abstract

Background: The incidence of peptic ulcer disease was expected to decrease following the introduction of acid inhibitors and Helicobacter pylori eradication., Aim: To analyse possible changes in the incidence of bleeding peptic ulcer, treatment and mortality over time., Methods: Residents of Malmö hospitalized for bleeding gastric or duodenal ulcer disease during 1987-2004 were identified in hospital databases (n = 1610). The material was divided into 6-year periods to identify changes over time. All patients who had been submitted to emergency surgery (n = 137) were reviewed., Results: The incidence rate for bleeding gastric or duodenal ulcers decreased by one half in males and by one-third in females and emergency operations decreased significantly (9.2%, 7.5% and 5.7% during the three time periods, respectively (P < 0.05). The post-operative mortality tended to decrease (9.7, 2.4 and 3.7%, respectively) and the 30-day mortality rates in the whole material were 1.2%, 3.6% and 3.4% during the different time periods., Conclusion: The incidence of bleeding gastric and duodenal ulcer disease has decreased markedly. Operative treatment has been replaced by endoscopic treatment. The bleeding ulcer-related mortality was less than 4% and has not changed over time.

Published
2009
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2. Increased ulcer relapse rate after PCV in smokers.

Author

Graffner H and Lindell G

Subjects
Adult, Duodenal Ulcer surgery, Female, Gastric Acid metabolism, Humans, Male, Middle Aged, Pylorus surgery, Recurrence, Stomach Ulcer surgery, Peptic Ulcer surgery, Smoking adverse effects, Vagotomy, Proximal Gastric
Published
1988
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7. On the Natural History of Peptic Ulcer

Author

Graffner H, Von Holstein Cs, Celebioglu F, and Lindell G

Subjects
Male, medicine.medical_specialty, Time Factors, Gastroenterology, Endoscopy, Gastrointestinal, Cohort Studies, Recurrence, Cause of Death, Internal medicine, medicine, Humans, Stomach Ulcer, Survival rate, Cause of death, Sweden, medicine.diagnostic_test, business.industry, Incidence, Incidence (epidemiology), Medical record, Age Factors, Middle Aged, medicine.disease, digestive system diseases, Endoscopy, Survival Rate, Natural history, Peptic Ulcer Hemorrhage, Histamine H2 Antagonists, Duodenal Ulcer, Peptic ulcer, Female, business, Follow-Up Studies, Cohort study
Abstract

Three out of 1000 individuals have peptic ulcer every year, and 20% of the ulcer episodes are associated with bleeding. Whether major innovations such as endoscopy and strong acid-suppressing drugs have had any impact on the natural course of peptic ulcer disease is largely unknown.Three hundred and fifty-one patients (median age, 63 years) with endoscopically proven peptic ulcer during 1979-1984 were included in the study and retrospectively followed up via medical records. The total population is based on two different groups of patients, the first comprising 229 consecutively diagnosed ulcer patients during 1979-81 and, to increase the number of bleeders, a second group including 122 bleeding ulcer patients consecutively diagnosed during 1981-84. At the end of the follow-up period all non-ulcer-operated patients were asked to answer a questionnaire on symptoms, investigations, and medication.The male to female ratio was 2.4:1 in duodenal ulcer patients, but a 1:1 ratio was shown both in gastric and prepyloric/pyloric ulcer patients (p0.001). Patients with bleeding ulcers were significantly older than non-bleeders (68 years versus 58 years; p0001), as were patients with gastric ulcers compared with prepyloric/pyloric or duodenal ulcer patients (68 years versus 63 and 61 years, respectively; p0.01). The 10-year cumulative mortality in the unselected group (median age, 62 years) was 43%, and the annual risk of dying of peptic ulcer disease was 0.6%. No difference in 10-year recurrence rate was seen between patients with bleeding ulcer at inclusion and non-bleeders (46.2% versus 44.3%; p = NS), but the annual risk of bleeding was 5.3% and 0.8%, respectively (p0.0001). In the group of patients answering the questionnaire 51% reported upper abdominal pain during the last year of follow-up.In spite of today's treatment regimens almost half of the patients with peptic ulcer disease experienced recurrence during a 10-year period, and more than half had ulcer symptoms after 10 years. Most probably, maintenance treatment with H2-receptor antagonists should have been offered more liberally during the 1980s.

Published
1994
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