1. Two new unsaturated fatty acids from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22.
- Author
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Liang ZY, Shen NX, Zheng YY, Wu JT, Miao L, Fu XM, Chen M, and Wang CY
- Subjects
- Antifungal Agents chemistry, Antifungal Agents isolation & purification, Antifungal Agents pharmacology, Carbon-13 Magnetic Resonance Spectroscopy, Crops, Agricultural microbiology, Fatty Acids, Unsaturated chemistry, Fatty Acids, Unsaturated pharmacology, Penicillium classification, Penicillium genetics, Phylogeny, Proton Magnetic Resonance Spectroscopy, Spectrometry, Mass, Electrospray Ionization, Fatty Acids, Unsaturated isolation & purification, Penicillium chemistry, Rhizosphere, Soil Microbiology, Wetlands
- Abstract
Two new unsaturated fatty acids, 6R,8R-dihydroxy-9Z,12Z-octadecadienoic acid (1) and methyl-6R,8R-dihydroxy-9Z,12Z-octadecadienoate (2), and two known 9Z,12Z-octadecadienoic acid analogues (3, 4) together with a known sesquiterpenoid (5) were isolated from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22. An acetonide derivative (1a) from 1 was also prepared. The relative configuration of 1 was determined by analysis of the 1D and 2D NOE spectra of 1a. The absolute configuration of 1 was assigned on the basis of biogenetic considerations. The antifungal activity of the high yield compound 5 was evaluated against four strains of crop pathogens and it showed significant antifungal activities against all the tested strains., (Copyright © 2019. Published by Elsevier Inc.)
- Published
- 2019
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