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Psoriasis is a chronic inflammatory skin disease that significantly impairs quality of life in a similar way like other serious diseases (diabetes mellitus, hypertension, cancer). The aim of this research was to determine the number of patients with psoriasis who are in out-patient care of dermatologists, their basic characteristics, and to evaluate the characteristics of topical therapy, compliance, financial effects of copayment and influence on the quality of life of patients. Methodology was chosen through a random selection of personal interviewing of doctors and patients across the country. The study included private dermatologists and patients with psoriasis on topical treatment. Totally 4 group discussion were held (12 physicians and 18 patients) concurrently with personal questionnaires (70 physicians and 142 patients). Totally 82 physicians and 160 patients participated in the period from May to June 2012. The results were in accordance with other European studies and confirms similar impact of psoriasis on quality of life. The study is so valuable in understanding the complexity of the disease and illuminates not only the relationship between psychological stress and the factors that lead to a deterioration in quality of life, but also helps to understand the importance of educational aid for quality of life with chronic disease. Last but not least, the study helped to assess the impact of socioeconomic status of patient on his treatment adherence. [ABSTRACT FROM AUTHOR]

The article discusses the case of 61-year-old woman receiving vemurafenib for metastatic melanoma who developed diclofenac-induced photoallergy. Topics covered include the findings of the molecular genetic examination of the melanoma, the risk of a severe photoallergic reaction of treatment with diclofenac and other nonsteroidal anti-inflammatory drugs (NSAIDS) in patients treated with vemurafenib, and the response of the patient to immunosuppressive corticosteroid therapy.

A letter to the editor is presented which discusses the case of a female patient with stage IV metastatic melanoma who developed chronic lymphocytic leukaemia during ipilimumab therapy.

The article discusses a medical case of a patient diagnosed with generalized pustular psoriasis of von Zumbusch, a skin disease and mentions the use of anti-inflammatory drug adalimumab for the treatment. Topics discussed include the treatment provide to the patients, the use of acitretin, cyclosporin, methotrexate and infliximab as the first line of anti-inflammatory agent and the authors suggestion to use adalimumab in the first line of therapy.