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2. Olaparib treatment for BRCA-mutant ovarian cancer with leptomeningeal disease

Author

Madeleine Bangham, Henry Walton, Jonathan A. Ledermann, and Robert Goldstein

Subjects
0301 basic medicine, endocrine system, Pathology, medicine.medical_specialty, animal structures, endocrine system diseases, Mutant, Case Report, Leptomeningeal disease, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ovarian cancer, medicine, LEPTOMENINGEAL DISEASE, skin and connective tissue diseases, business.industry, BRCA mutation, Obstetrics and Gynecology, Brain metastases, medicine.disease, female genital diseases and pregnancy complications, PARP inhibitor, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer research, business
Abstract

Highlights • Leptomeningeal disease occurs more commonly in BRCA-mutated ovarian cancer. • A clinically significant dose of olaprib is able to penetrate the leptomeninges. • Leptomeningeal metastases in a BRCA-mutated ovarian cancer responded to olaparib.

Published
2016
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