6 results on '"ASANO, Nadja Maria Jorge"'
Search Results
2. Respiratory muscle strength and lung function in the stages of Parkinson's disease.
- Author
-
dos Santos, Rejane Barreto, Fraga, Anderson Santos, das Graças Wanderley de Sales Coriolano, Maria, Tiburtino, Bruna Ferreira, Lins, Otávio Gomes, Esteves, Ana Cristina Falcão, and Asano, Nadja Maria Jorge
- Subjects
RESPIRATORY muscles ,MUSCLE strength ,PARKINSON'S disease ,LUNGS ,MOTOR ability ,QUALITY of life - Abstract
Objective: To investigate parameters of lung function and respiratory muscle strength in different stages of Parkinson's disease (PD), as well as to determine their correlation with motor function and quality of life. Methods: This was a cross-sectional study conducted at a referral center for PD in the city of Recife, Brazil. Respiratory muscle strength and lung function, as well as their relationship with motor function and quality of life, were evaluated in patients with PD, stratified by the level of severity, and were compared with the data obtained for a control group. After confirming the normality of data distribution, we performed one-way ANOVA with a post hoc t-test. Results: The sample comprised 66 individuals, in two groups: PD (n = 49) and control (n = 17). All of the parameters investigated showed inverse correlations with PD severity, and there were significant differences among the levels of severity, as well as between the PD and control groups, in terms of the MIP, MEP, FVC, FEV
1 , and FEF25-75% . The lung function parameters also showed moderate to weak inverse correlations with bradykinesia and rigidity. On a quality of life questionnaire, the total score and mobility domain score both presented a moderate inverse correlation with FVC, FEV1 , PEF, and MEP. Conclusions: Respiratory muscle strength and some lung function parameters are impaired from the early stages of PD onward, bradykinesia and rigidity being the cardinal signs that correlate most strongly with impairment of those parameters. Such alterations negatively affect the quality of life of patients with PD. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
3. Pharmacogenetic Profile and the Occurrence of Visual Hallucinations in Patients With Sporadic Parkinson's Disease.
- Author
-
Damasceno dos Santos, Erinaldo Ubirajara, Duarte, Elaine Bandeira Cavalcanti, Miranda, Laura Maria Ramos, Asano, Amdore Guescel C., Asano, Nadja Maria Jorge, Maia, Maria De Mascena Diniz, and Souza, Paulo Roberto Eleutério
- Subjects
CONFIDENCE intervals ,GENES ,GENETIC polymorphisms ,HALLUCINATIONS ,PARKINSON'S disease ,PHARMACOGENOMICS ,POISSON distribution ,POLYMERASE chain reaction ,TRANSDERMAL medication ,GENOTYPES ,DISEASE complications - Abstract
Visual hallucinations are significant nonmotor symptoms in the course of treatment of Parkinson's disease. Previous studies have shown that the interindividual variability and pharmacogenetic profile of Parkinson's disease patients seem to influence the occurrence of visual hallucinations. In our study, we investigated a possible relationship of sequence variants in DRD1, DRD2, DRD3, DAT1, and COMT genes with the presence of visual hallucinations in Parkinson's disease patients. A total of 224 Brazilian patients from the Pro‐Parkinson service at the Clinical Hospital of the University of Pernambuco, diagnosed with sporadic Parkinson's disease, were enrolled. Parkinson's disease patients were divided into 2 groups based on the presence or absence of visual hallucinations. The sequence variants for DRD1, DRD2, DRD3, DAT1, and COMT were determined through the polymerase chain reaction‐restriction fragment length polymorphism technique. Multiple Poisson regression analyses showed that individuals carrying the DRD3 Ser/Ser and Ser/Gly genotypes presented increased prevalence ratios of visual hallucinations (9.7‐fold and 4.4‐fold, respectively; P <.001). Regarding DAT1 rs28363170, there was a 9.82‐fold increase in the prevalence ratio in patients with the 10/11 genotype, 8.78‐fold for the 10/8 genotype, and 2.44‐fold for the 9/8 genotypes (P <.001, for all). In addition, visual hallucinations were also associated with use of transdermal patches with rotigotine (PR, 3.7; 95%CI, 1.2‐10.9; P =.017) and rasagiline (PR, 2.8; 95%CI, 1.3‐6.0; P =.006). Our results suggest that the genetic variants DRD3 and DAT1, along with other therapeutic confounders, may influence the prevalence ratio of visual hallucinations. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
4. The influence of SLC6A3 and DRD2 polymorphisms on levodopa‐therapy in patients with sporadic Parkinson's disease.
- Author
-
Santos, Erinaldo Ubirajara Damasceno, Sampaio, Tiago F., Tenório dos Santos, Aléxia D., Bezerra Leite, Fernanda C., Silva, Ronaldo C., Crovella, Sergio, Asano, Amdore Guescel C., Asano, Nadja Maria Jorge, and Souza, Paulo Roberto E.
- Subjects
PARKINSON'S disease ,GENETIC polymorphisms ,DOPAMINE ,EXTRAPYRAMIDAL disorders ,BRAIN diseases - Abstract
Objectives: The aim of this study was to evaluate a possible relationship between DRD2/ANKK1 (rs1800497) and SLC6A3/DAT1 (rs28363170) gene polymorphisms with the response to levodopa (L‐DOPA)‐therapy in patients with Parkinson's disease (PD). Methods: One hundred and ninety‐five patients with idiopathic PD were investigated. Patients were genotyped for rs1800497 and rs28363170 polymorphisms using PCR‐RFLP. Logistic regression was performed to assess the association of polymorphisms with the occurrence of the chronic complications of L‐DOPA therapy. Key findings: Our results showed association between the occurrence of dyskinesia with an increased greater disease severity (P = 0.007), higher L‐DOPA dose (P = 0.007) and use of dopamine agonist (P = 0.020). Moreover, there were significant protective effects for age (P = 0.004) and male subjects (P = 0.006). Conclusions: Clinical and demographic characteristics of Brazilian PD patients and differences in DRD2 and DAT1 genes may to determine individual variations in the therapeutic response to L‐DOPA in the Brazilian PD patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
5. The influence of SLC6A3 and DRD2 polymorphisms on levodopa-therapy in patients with sporadic Parkinson's disease
- Author
-
Amdore Guescel C Asano, Tiago Furtado Sampaio, Sergio Crovella, Erinaldo Ubirajara Damasceno dos Santos, Ronaldo Celerino da Silva, Paulo Roberto Eleutério de Souza, Fernanda Cristina Bezerra Leite, Aléxia D. Tenório dos Santos, Nadja Maria Jorge Asano, dos Santos, Erinaldo Ubirajara Damasceno, Sampaio, Tiago F., Tenório dos Santos, Aléxia D., Bezerra Leite, Fernanda C., da Silva, Ronaldo C., Crovella, Sergio, Asano, Amdore Guescel C., Asano, Nadja Maria Jorge, and de Souza, Paulo Roberto E.
- Subjects
Male ,Parkinson's disease ,dopamine transporter ,genetic polymorphism ,pharmacogenetics ,side effects ,Pharmacology ,3003 ,Pharmaceutical Science ,Disease ,Logistic regression ,Severity of Illness Index ,030226 pharmacology & pharmacy ,Gastroenterology ,Antiparkinson Agents ,Levodopa ,0302 clinical medicine ,ANKK1 ,Age Factors ,Parkinson Disease ,Middle Aged ,Treatment Outcome ,030220 oncology & carcinogenesis ,pharmacogenetic ,Female ,medicine.symptom ,Brazil ,medicine.drug ,Adult ,medicine.medical_specialty ,Genotype ,side effect ,Protein Serine-Threonine Kinases ,Dopamine agonist ,03 medical and health sciences ,Sex Factors ,Internal medicine ,medicine ,Humans ,Aged ,Dopamine Plasma Membrane Transport Proteins ,Polymorphism, Genetic ,Dose-Response Relationship, Drug ,Receptors, Dopamine D2 ,business.industry ,medicine.disease ,Logistic Models ,Dyskinesia ,business ,Pharmacogenetics - Abstract
Objectives The aim of this study was to evaluate a possible relationship between DRD2/ANKK1 (rs1800497) and SLC6A3/DAT1 (rs28363170) gene polymorphisms with the response to levodopa (L-DOPA)-therapy in patients with Parkinson's disease (PD). Methods One hundred and ninety-five patients with idiopathic PD were investigated. Patients were genotyped for rs1800497 and rs28363170 polymorphisms using PCR-RFLP. Logistic regression was performed to assess the association of polymorphisms with the occurrence of the chronic complications of L-DOPA therapy. Key findings Our results showed association between the occurrence of dyskinesia with an increased greater disease severity (P = 0.007), higher L-DOPA dose (P = 0.007) and use of dopamine agonist (P = 0.020). Moreover, there were significant protective effects for age (P = 0.004) and male subjects (P = 0.006). Conclusions Clinical and demographic characteristics of Brazilian PD patients and differences in DRD2 and DAT1 genes may to determine individual variations in the therapeutic response to L-DOPA in the Brazilian PD patients.
- Published
- 2019
6. MAO-B and COMT Genetic Variations Associated With Levodopa Treatment Response in Patients With Parkinson's Disease
- Author
-
Sergio Crovella, Gessica Dayane Cordeiro de Lima, Tiago Furtado Sampaio, Amdore Guescel C Asano, Paulo Roberto Eleutério de Souza, Rute Salgues Gueiros dos Anjos, Nadja Maria Jorge Asano, Erinaldo Ubirajara Damasceno dos Santos, Ronaldo Celerino da Silva, Sampaio, Tiago Furtado, dos Santos, Erinaldo Ubirajara Damasceno, de Lima, Gessica Dayane Cordeiro, dos Anjos, Rute Salgues Gueiro, da Silva, Ronaldo Celerino, Asano, Amdore Guescel C., Asano, Nadja Maria Jorge, Crovella, Sergio, and de Souza, Paulo Roberto Eleutério
- Subjects
0301 basic medicine ,Male ,Parkinson's disease ,Pharmacogenomic Variants ,Dopamine ,COMT inhibitor ,Antiparkinson Agents ,chemistry.chemical_compound ,0302 clinical medicine ,Surveys and Questionnaires ,Pharmacology (medical) ,Sex Characteristics ,Parkinson Disease ,Middle Aged ,Female ,Monoamine oxidase B ,medicine.symptom ,Brazil ,medicine.drug ,rs4680 ,Adult ,Levodopa ,medicine.medical_specialty ,Genotype ,Biological Availability ,Single-nucleotide polymorphism ,Catechol O-Methyltransferase ,Polymorphism, Single Nucleotide ,MAO-B ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,levodopa ,Monoamine Oxidase ,Aged ,Retrospective Studies ,Pharmacology ,Dyskinesias ,Dose-Response Relationship, Drug ,business.industry ,medicine.disease ,COMT ,nervous system diseases ,dyskinesia ,030104 developmental biology ,Endocrinology ,Dyskinesia ,chemistry ,business ,polymorphisms ,030217 neurology & neurosurgery - Abstract
The most commonly used Parkinson's disease (PD) treatment is the replacement of dopamine by its levodopa precursor (l-dopa). Monoamine oxidase-B (MAO-B) and catechol-o-methyl transferase (COMT) are enzymes involved in the metabolism and regulation of dopamine availability. In our study we investigated the possible relation among selected single-nucleotide polymorphisms (SNPs) in the MAO-B (rs1799836) and COMT (rs4680) genes and the therapeutic response to levodopa (l-dopa). A total of 162 Brazilian patients from the Pro-Parkinson service of Clinics Hospital of Pernambuco diagnosed with sporadic PD and treated with levodopa were enrolled. PD patients were stratified into 2 groups according to the daily levodopa dose. MAO-B and COMT SNP genotyping was conducted by polymerase chain reaction-restriction fragment length polymorphism. After multivariate analysis, we observed a significant difference between PD groups for the following variables: sex (P = .02), longer duration of disease (P = .02), longer levodopa therapy duration (P = .01), younger onset of PD (P = .01), and use of COMT inhibitor (P = .02). We observed that patients carrying MAO-B (rs1799836) A and AA genotypes and COMT (rs4680) LL genotype suffered more frequently from levodopa-induced-dyskinesia. In addition, we found an increased risk of 2.84-fold for male individuals carrying the MAO-B G allele to be treated with higher doses of levodopa (P = .04). We concluded that before beginning PD pharmacological treatment, it is important to consider the genetic variants of the MAO-B and COMT genes and the sex, reinforcing the evidence that sexual dimorphism in the genes related to dopamine metabolism might affect PD treatment.
- Published
- 2018
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.