1. Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition.
- Author
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Arrieta F, Martinez-Vaello V, Bengoa N, Rosillo M, de Pablo A, Voguel C, Pintor R, Belanger-Quintana A, Mateo-Lobo R, Candela A, and Botella-Carretero JI
- Subjects
- Aged, Biomarkers blood, COVID-19 complications, COVID-19 mortality, Critical Care Outcomes, Critical Illness mortality, Female, Humans, Hyperglycemia mortality, Hyperglycemia virology, Intensive Care Units, Length of Stay statistics & numerical data, Male, Middle Aged, Prognosis, COVID-19 blood, Hyperglycemia blood, Osteocalcin blood, Parenteral Nutrition mortality, SARS-CoV-2
- Abstract
We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. Fifty-two critical patients at the intensive care unit (ICU), 26 with COVID-19 and 26 non-COVID-19, were included. Glycemic control, delivery of artificial nutrition, serum osteocalcin, total and ICU stays, and mortality were recorded. Patients with COVID-19 had higher ICU stays, were on artificial nutrition for longer ( p = 0.004), and needed more frequently insulin infusion therapy ( p = 0.022) to control stress hyperglycemia. The need for insulin infusion therapy was associated with higher energy ( p = 0.001) and glucose delivered through artificial nutrition ( p = 0.040). Those patients with stress hyperglycemia showed higher ICU stays (23 ± 17 vs. 11 ± 13 days, p = 0.007). Serum osteocalcin was a good marker for hyperglycemia, as it inversely correlated with glycemia at admission in the ICU ( r = -0.476, p = 0.001) and at days 2 ( r = -0.409, p = 0.007) and 3 ( r = -0.351, p = 0.049). In conclusion, hyperglycemia in critically ill COVID-19 patients was associated with longer ICU stays. Low circulating osteocalcin was a good marker for stress hyperglycemia.
- Published
- 2021
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