1. Cost-effectiveness of liquid-based cytology with or without hybrid-capture II HPV test compared with conventional Pap smears: a study by the French Society of Clinical Cytology.
- Author
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Cochand-Priollet B, Cartier I, de Cremoux P, Le Galès C, Ziol M, Molinié V, Petitjean A, Dosda A, Merea E, Biaggi A, Gouget I, Arkwright S, Vacher-Lavenu MC, Vielh P, and Coste J
- Subjects
- Adult, Biopsy economics, Biopsy methods, Cost-Benefit Analysis, Female, France, Humans, Mass Screening, Papillomaviridae genetics, Papillomavirus Infections diagnosis, Sensitivity and Specificity, Uterine Cervical Neoplasms virology, Vaginal Smears methods, Uterine Cervical Dysplasia virology, Papanicolaou Test, Papillomaviridae isolation & purification, Uterine Cervical Neoplasms diagnosis, Vaginal Smears economics, Uterine Cervical Dysplasia diagnosis
- Abstract
Many articles concerning conventional Pap smears, ThinPrep liquid-based cytology (LBC) and Hybrid-Capture II HPV test (HC II) have been published. This study, carried out by the French Society of Clinical Cytology, may be conspicuous for several reasons: it was financially independent; it compared the efficiency of the conventional Pap smear and LBC, of the conventional Pap smear and HC II, and included an economic study based on real costs; for all the women, a "gold standard" reference method, colposcopy, was available and biopsies were performed whenever a lesion was detected; The conventional Pap smear, the LBC (split-sample technique), the colposcopy, and the biopsies were done at the same time. This study included 2,585 women shared into two groups: a group A of a high-risk population, a group B of a screening population. The statistical analysis of the results showed that conventional Pap smears consistently had superior or equivalent sensitivity and specificity than LBC for the lesions at threshold CIN-I (Cervical Intraepithelial Neoplasia) or CIN-II or higher. It underlined the low specificity of the HC II. Finally, the LBC mean cost was never covered by the Social Security tariff.
- Published
- 2005
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