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The authors improved the probe assay of the pancreas: an original euphylline-calcium test was developed. The examination is informative and safe in the diagnostics of the chronic relapsing pancreatitis. A number of advantages of the optimized method of diagnostics before the traditional ones, including the secretin-pancreazimin test, were proven.

Ultrasonic histogramme was studied in 35 patients with chronic pancreatitis and 20 donors, taken in the area of the head and body of the pancreas, as were levels of immunoreactive trypsin--fasting and after standard food load,--and C-peptide in blood serum on an empty stomach. To increase informative value and specificity of ultrasonic and radioimmunologic investigations an index has been suggested, based on the findings from histogramme and radioimmunity analysis.

As many as 12 patients with pseudotumorous chronic pancreatitis have been examined. While studying the functional state of the pancreas a conclusion was reached about a decrease in the organ's exocrine activity, with the hormone output remaining unaffected. Particular features of the immunity status in the patients are outlined. It is recommended that dynamic ultrasonic investigation and computerized tomography to the abdominal cavity and retroperitoneal space, transcutaneous puncture biopsy of the pancreas, should be used for the differential diagnosis with carcinoma of the organ to be made possible.

Analysis of clinical and immunologic parallels in 200 patients with chronic pancreatitis has revealed that lymphocyte autosensitization to pancreatic tissue in the lymphocyte blastogenesis test (LBGT) is in high correlation with the frequency of the disease recurrences, and the severity of pancreatic exocrine insufficiency with the immune complex level. This permits recommending LBGT with pancreatic tissue antigen for the prediction of the condition recurrences, and measurements of the immune complexes level for the prediction of the developing exocrine pancreatic insufficiency.