1. Cyst Fluid Carcinoembryonic Antigen Level Difference between Mucinous Cystic Neoplasms and Intraductal Papillary Mucinous Neoplasms
- Author
-
Köker, Ibrahim Hakkı, Ünver, Nurcan, Malya, Fatma Ümit, Uysal, Ömer, Keskin, Elmas Biberci, Şentürk, Hakan, MALYA, FATMA ÜMİT, and UYSAL, ÖMER
- Subjects
lcsh:Internal medicine ,medicine.medical_specialty ,endocrine system diseases ,Medicine (miscellaneous) ,Malignancy ,Gastroenterology ,KÖKER İ. H. , Ünver N., MALYA F. Ü. , UYSAL Ö., BİBERCİ KESKİN E., ŞENTÜRK H., -Cyst Fluid Carcinoembryonic Antigen Level Difference between Mucinous Cystic Neoplasms and Intraductal Papillary Mucinous Neoplasms-, Clinical Endoscopy, 2020 ,03 medical and health sciences ,0302 clinical medicine ,Carcinoembryonic antigen ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Cyst ,lcsh:RC799-869 ,lcsh:RC31-1245 ,Invasive carcinoma ,Receiver operating characteristic ,biology ,business.industry ,Histology ,medicine.disease ,Dysplasia ,Pancreatic cysts ,030220 oncology & carcinogenesis ,biology.protein ,lcsh:Diseases of the digestive system. Gastroenterology ,Original Article ,030211 gastroenterology & hepatology ,business - Abstract
Background/aims: The role of cyst fluid carcinoembryonic antigen (CEA) level in differentiating mucinous pancreatic cystic lesions (PCLs) is controversial. We investigated the role of cyst fluid CEA in differentiating low-risk (LR)-intraductal papillary mucinous neoplasms (IPMNs) from high-risk (HR)-IPMNs and LR-mucinous cystic neoplasms (MCNs). Methods: This was a retrospective study of 466 patients with PCLs who underwent endoscopic ultrasound-guided fine-needleaspiration over a 7-year period. On histology, low-grade dysplasia and intermediate-grade dysplasia were considered LR, whereas high-grade dysplasia and invasive carcinoma were considered HR. Results: Data on cyst fluid CEA levels were available for 50/102 mucinous PCLs with definitive diagnoses. The median CEA (range) levels were significantly higher in HR cysts than in LR cysts (2,624 [0.5-266,510] ng/mL vs. 100 [16.8-53,445]ng/mL, p=0.0012). The area under the receiver operating characteristic curve (AUROC) was 0.930 (95% confidence interval [CI], 0.5-0.8; p100ng/mL, with a negative predictive value (NPV) of 100%. Conclusion: Cyst fluid CEA levels significantly vary between LR-IPMNs, LR-MCNs, and HR-IPMNs. A CEA cutoff level of >100ng/mL had a 100% NPV in differentiating LR-IPMNs from LR-MCNs and HR-IPMNs.
- Published
- 2021