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Your search keyword '"Ambo, Yoshiyasu"' showing total 5 results
Start Over Author "Ambo, Yoshiyasu" Topic pancreatic cancer
5 results on '"Ambo, Yoshiyasu"'

1. No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy

Author

Maeda, Hiromichi, Okada, Ken-ichi, Fujii, Tsutomu, Oba, Mari S, Kawai, Manabu, Hirono, Seiko, Kodera, Yasuhiro, Sho, Masayuki, Akahori, Takahiro, Shimizu, Yasuhiro, Ambo, Yoshiyasu, Kondo, Naru, Murakami, Yoshiaki, Ohuchida, Jiro, Eguchi, Hidetoshi, Nagano, Hiroaki, Sakamoto, Junichi, and Yamaue, Hiroki

Subjects
Kampo, herbal medicine, pancreatic cancer, TNF, Daikenchuto, Original Research
Abstract

Aim and Background TJ-100 is a traditional Japanese medicine that affects inflammation and gastrointestinal motility, and is used as a preventive and treatment for paralytic ileus. This study aims at determining the effect of TJ-100 on the peritoneal levels of IFN-γ/IL-9, cytokines related to ileus, after pancreaticoduodenectomy (PD) in a clinical setting. Methods This was a subsidiary study of the clinical trial investigating the effect of TJ-100 on postoperative bowel function. Ascites was collected from 180 patients using an abdominal drainage tube on postoperative day 1 and 3 after PD (POD 1 or POD 3) and used to measure 27 cytokines. We performed univariate and multivariate analyses using several perioperative variables and administration of TJ-100/placebo to determine the effect of TJ-100 on the levels of IFN-γ and IL-9. Results Peritoneal levels of IL-9 and IFN-γ decreased between POD 1 and 3 (Wilcoxon signed-rank test p

Published
2020

5. Transition of serum cytokines following pancreaticoduodenectomy: A subsidiary study of JAPAN-PD.

Author

Maeda, Hiromichi, Okada, Ken-Ichi, Fujii, Tsutomu, Oba, Mari S., Kawai, Manabu, Hirono, Seiko, Kodera, Yasuhiro, Sho, Masayuki, Akahori, Takahiro, Shimizu, Yasuhiro, Ambo, Yoshiyasu, Kondo, Naru, Murakami, Yoshiaki, Ohuchida, Jiro, Eguchi, Hidetoshi, Nagano, Hiroaki, Sakamoto, Junichi, and Yamaue, Hiroki

Subjects
PANCREATICODUODENECTOMY, PANCREATECTOMY, RANDOMIZED controlled trials, INTERLEUKIN receptors, PLACEBOS
Abstract

Our previous study aimed to examine the effect of TJ-100, a widely used herbal medicine, on intestinal function following pancreaticoduodenectomy (PD) in a multicenter, randomized, double-blinded, placebo-controlled manner (JAPAN-PD study). This concomitant study investigated the effect of TJ-100 on serum cytokine levels in patients who underwent PD. Due to the fact that several clinical variables can affect the absolute values of baseline serum cytokine levels, the ratios of the cytokine levels on postoperative day (POD)3 to those on POD1 were also used for analysis. The present study enrolled 180/224 randomized patients, of whom 91 received TJ-100 and 89 received placebo. As the main findings of the analysis, Wilcoxon signed-rank test revealed no significant difference in the levels of serum cytokines between the groups; however, patients in the TJ-100 group without severe inflammatory complications exhibited significantly higher ratios of interleukin (IL)-4 (n=123), IL-9 (n=72), IL-10 (n=97), PDGF-BB (n=143) and tumor necrosis factor-α (n=135), compared with patients in the Placebo Group (P<0.05). According to the results of the present study, TJ-100 has an effect on the change in serum cytokine levels from POD1 to POD3 following PD. However, the role of different transition pattern of cytokines in postoperative recovery following PD has to be investigated by further mechanical studies focusing on these extracted cytokines (ClinicalTrials.gov ; no. NCT01607307; May 30, 2012). [ABSTRACT FROM AUTHOR]

Published
2018
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