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4 results on '"Hersey SJ"'

1. Interactions between oxidative metabolism and acid secretion in gastric mucosa.

Author

Hersey SJ

Subjects
Aerobiosis, Amobarbital pharmacology, Anaerobiosis, Animals, Cyclic AMP metabolism, Cyclic AMP pharmacology, Cytochromes metabolism, Flavoproteins metabolism, Gastric Mucosa drug effects, Gastric Mucosa ultrastructure, Histocytochemistry, Hydrogen-Ion Concentration, Kinetics, Microscopy, Electron, Mitochondria metabolism, NADH, NADPH Oxidoreductases metabolism, Oxidation-Reduction, Pentagastrin pharmacology, Rana catesbeiana, Spectrophotometry, Theophylline pharmacology, Thiocyanates pharmacology, Gastric Juice metabolism, Gastric Mucosa metabolism, Oxidative Phosphorylation drug effects, Oxygen Consumption drug effects
Published
1974
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2. Effect of unstirred layers on oxygenation of frog gastric mucosa.

Author

Hersey SJ and High WL

Subjects
Animals, Anura, Biochemistry instrumentation, Cytochrome c Group metabolism, Cytochromes metabolism, Electric Conductivity, Electron Transport, Gastric Mucosa anatomy & histology, In Vitro Techniques, Models, Biological, Oxidation-Reduction, Rana catesbeiana, Secretory Rate, Spectrophotometry, Temperature, Gastric Juice metabolism, Gastric Mucosa metabolism, Oxygen Consumption
Published
1972
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3. A dual effect of sodium on oxygen consumption in toad bladder.

Author

Hersey SJ

Subjects
Animals, Anura, Biological Transport, Active, Drug Synergism, Electrodes, Membrane Potentials, Potentiometry, Sodium metabolism, Stimulation, Chemical, Dinitrophenols pharmacology, Membranes metabolism, Oxygen Consumption drug effects, Sodium pharmacology, Urinary Bladder metabolism
Published
1969
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4. The energetic coupling of acid secretion in gastric mucosa

Author

Hersey Sj

Subjects
High-energy phosphate, Cytochrome, Intracellular pH, Respiratory chain, Action Potentials, Biological Transport, Active, Redox, Adenosine Triphosphate, Oxygen Consumption, Gastric mucosa, medicine, Animals, Secretion, Adenosine Triphosphatases, Gastric Juice, biology, Chemistry, Spectrum Analysis, Hydrogen-Ion Concentration, Water-Electrolyte Balance, Mitochondria, Adenosine Diphosphate, Ion Exchange, Coupling (electronics), Bicarbonates, Kinetics, medicine.anatomical_structure, Biochemistry, Gastric Mucosa, biology.protein, Cytochromes, sense organs, Anura, Oxidation-Reduction, Thiocyanates, Histamine
Abstract

The relation between acid secretion and oxidative metabolism has been investigated using nondestructive optical techniques to monitor the redox level of respiratory chain components in the intact, isolated bull-frog gastric mucosa. High rates of acid secretion are found to be associated with cytochrome reduction while inhibition of secretion results in oxidation of the respiratory chain components. Changes in chloride secretion, independent of hydrogen ion secretion, result in opposite cytochrome redox changes indicating that the interaction with oxidative metabolism differs for the two secretory processes. Measurement of intracellular pH changes using indicator dyes shows a correlation between cytochrome reduction and increased pH. The results suggest that there exists a close coupling between the respiratory chain components and hydrogen ion secretion and that this coupling may involve changes in intracellular pH rather than changes in high energy phosphate compounds as previously suggested.

Published
1971
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