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Researchers at the University Hospital and Faculty of Medicine in Pilsen conducted a study on the use of kaolin in combination with mechanical compression for postprocedural radial artery hemostasis. The study involved 712 patients undergoing coronary angiography or intervention, with results showing that the use of kaolin led to shorter compression times in both proximal and distal radial artery approaches. Additionally, distal radial artery approaches were associated with a lower incidence of hematomas and shorter compression times compared to proximal approaches, with no cases of proximal radial artery occlusion reported. [Extracted from the article]

Researchers have submitted a patent application for a "System and Method for Transistor Pathogen Detector" to the USPTO. The invention aims to provide a practical and efficient pathogen virus detector, specifically targeting the SARS-COV2 virus responsible for COVID-19. The system involves layers of nanocrystalline diamond, graphene oxide, fluorinated graphene oxide, and pathogen receptors to function as a biosensor field effect transistor. This technology could potentially contribute to rapid and accurate diagnosis of infectious diseases for public health containment efforts. [Extracted from the article]

A recent study conducted at Jilin University in Changchun, People's Republic of China, focused on the relationship between zeolite crystal size, Bronsted acid site distribution, and dual-cycle selectivity in the methanol-to-olefins reaction. The research found that larger-sized ZSM-5 zeolites have a higher concentration of paired Bronsted acid sites, which influences the aromatic-based cycle in the reaction. The study utilized advanced techniques such as two-dimensional solid-state nuclear magnetic resonance and transmission electron microscopy to analyze the mechanisms involved. The findings suggest that paired Bronsted acid sites play a significant role in reducing activation energy barriers and favoring certain reaction pathways. [Extracted from the article]

Researchers at KLE Technological University in Karnataka, India, have developed an electrochemical sensor based on bentonite clay for detecting the antiviral drug Valganciclovir (VLGC). The sensor showed a detection limit of 13.5 nM for VLGC and good sensitivity, making it suitable for tracking trace levels of the drug in clinical and environmental samples. The study concluded that the developed sensor holds promise for future research in detecting other bio-active molecules in pharmaceutical and clinical samples. This research was supported by the Science and Engineering Research Board (SERB) and King Saud University. [Extracted from the article]

A patent has been issued for a hydrocortisone acetate suppository formulation by Cristcot LLC, designed for the treatment of gastrointestinal diseases like ulcerative colitis. The formulation includes hydrocortisone acetate and colloidal silicon dioxide, offering advantages such as improved retention and reduced absorption variability. This innovation aims to provide a safer and more effective treatment option for patients with conditions like ulcerative colitis, Crohn's disease, and inflammatory bowel disease. [Extracted from the article]

A patent has been issued for a hydrocortisone acetate suppository formulation by Cristcot LLC, aimed at treating gastrointestinal diseases like ulcerative colitis. The formulation includes hydrocortisone acetate and colloidal silicon dioxide, offering advantages over existing suppository formulations. The patent highlights the need for safer and more effective treatments for gastrointestinal diseases, emphasizing the potential benefits of this new formulation. [Extracted from the article]

A patent has been issued for a hydrocortisone acetate suppository formulation by Cristcot LLC, designed for the treatment of gastrointestinal diseases like ulcerative colitis and Crohn's disease. The formulation includes specific percentages of hydrocortisone acetate and colloidal silicon dioxide, aiming to improve drug delivery and reduce absorption variability. This invention addresses the need for safer and more effective hydrocortisone suppository formulations for gastrointestinal diseases, offering potential benefits over existing treatments. [Extracted from the article]

Researchers from Gyeongsang National University conducted a study on the impact of temperature and light on sunburn in 'Fuyu' sweet persimmons. They found that exposure to strong light led to extensive sunburn damage, but the application of kaolin and kaolin-carnauba wax mixture effectively reduced sunburn by up to 30%. The study concluded that the kaolin treatment combined with carnauba wax was the most effective in preventing sunburn damage in 'Fuyu' persimmons under specific environmental conditions. The research was funded by various organizations in South Korea and has been peer-reviewed. [Extracted from the article]

A patent has been issued for a hydrocortisone acetate suppository formulation by Cristcot LLC, aimed at treating gastrointestinal diseases like ulcerative colitis and Crohn's disease. The formulation includes hydrocortisone acetate and colloidal silicon dioxide, with specific weight percentages and release profiles. The invention aims to provide a safer and more effective treatment option for patients with these conditions, offering advantages over current rectal drug formulations of hydrocortisone. [Extracted from the article]

A patent has been issued for spray-dried dispersions, formulations, and polymorphs of a specific compound related to BTK inhibitors, which are used in cancer treatment and autoimmune disorders. The patent provides pharmaceutical compositions with specific ratios of ingredients to improve solubility and plasma concentrations of the compound. The patent aims to address the need for enhanced formulations of BTK inhibitors, particularly those with low solubility, to improve treatment outcomes for various conditions. [Extracted from the article]

Researchers at the University of Torbat Heydarieh in Iran conducted a study on the adsorption characteristics of modified bentonites for purifying anthocyanin from saffron tepal. The study found that the best adsorption performance was achieved with acid and thermal activation of bentonite, resulting in a higher adsorption capacity compared to other methods. The research concluded that the activation of bentonite by both acid and heat exhibited more adsorption than bentonite modified by only acid or thermal methods. This study provides valuable insights into the purification of anthocyanin from saffron tepal using modified bentonites. [Extracted from the article]

A recent study conducted at the University of Tehran in Iran has explored the use of smart materials for delivering anticancer drugs to tumors. The researchers developed a pH-responsive system using magnetite nanoparticles and bentonite loaded with doxorubicin, an anticancer drug. The structural and spectral properties of the nanohybrid were analyzed, and its drug-loading capacity and release were measured. The results showed that the magnetic bentonite nanohybrid has potential as a drug delivery system for targeting cancer cells. [Extracted from the article]

Cristcot LLC has been issued a patent for a hydrocortisone acetate suppository formulation for the treatment of gastrointestinal diseases such as ulcerative colitis, Crohn's disease, and inflammatory bowel disease. The formulation contains hydrocortisone acetate and colloidal silicon dioxide, and it has advantages over previous suppository formulations, including improved patient retention and reduced absorption variability. The suppository has a weight of 2 grams and releases at least 80% of the hydrocortisone acetate within 180 minutes. The patent also describes alternative configurations of suppositories that allow for easier application and greater surface area for drug delivery. [Extracted from the article]

A patent has been issued to Allergan Holdings Unlimited Company for opioid receptor modulator dosage formulations. The patent describes solid oral pharmaceutical formulations of a specific active ingredient with improved stability and unique physico-chemical features that may deter or limit abuse. The formulations consist of the active ingredient and inert ingredients such as silicified microcrystalline cellulose, colloidal silicon dioxide, crospovidone, mannitol, and magnesium stearate. The patent also includes methods of reducing abdominal pain and diarrhea in patients with irritable bowel syndrome with diarrhea by orally administering the formulation. [Extracted from the article]

Researchers from Kermanshah University of Medical Sciences in Iran have explored the potential of bentonite clay in protecting intestinal flora and alleviating pseudomembranous colitis caused by antibiotic usage. Antibiotics can disrupt the natural balance of gut flora, leading to opportunistic infections. The researchers believe that bentonite clay, with its adsorption properties, antibacterial and anti-inflammatory traits, and contribution to wound healing, could mitigate the detrimental effects of antibiotics on the gut microbiota. Further research is needed to fully understand the therapeutic effects of bentonite clay in combating this condition. [Extracted from the article]

Cristcot LLC has been issued a patent for a hydrocortisone acetate suppository formulation for the treatment of gastrointestinal diseases such as ulcerative colitis, Crohn's disease, and inflammatory bowel disease. The formulation contains hydrocortisone acetate and colloidal silicon dioxide, and may also include an oleaginous base and butylated hydroxytoluene. The suppository is designed to release at least 80% of the hydrocortisone acetate within 180 minutes and has a specific shape to facilitate drug delivery. This patent addresses the need for safer and more effective hydrocortisone suppository formulations for these diseases. [Extracted from the article]

A study conducted by researchers at Henan University of Technology in Zhengzhou, China, has found that incorporating cinnamaldehyde and nonanal into polyvinyl alcohol (PVA) films, along with colloidal silicon dioxide (CSD), can enhance the antifungal properties of the films. The addition of CSD improved water resistance and tensile strength, while the combination of cinnamaldehyde and nonanal showed a synergistic effect against Aspergillus flavus. The composite film demonstrated high UV barrier, water resistance, mechanical properties, and antifungal activity, making it a promising option for food packaging. The research was supported by the Natural Science Foundation of Henan. [Extracted from the article]

Researchers from Wuhan University in China have developed a new approach to address the shuttle effect in lithium-sulfur batteries (LSBs). The shuttle effect, caused by the movement of polysulfides, can hinder the long-term operation of LSBs. The researchers used organic bentonite to construct a gel-type physical barrier that repels polysulfides, resulting in improved stability and cycle stability of the batteries. This strategy sacrifices initial efficiency for long-term stability and provides a new solution to the shuttle effect. The research has been peer-reviewed and published in Energy Storage Materials. [Extracted from the article]

The article reports on the issuance of patent for packaging method for circuit units comprising circuit baseplate to Weifang Goertek Microelectronics Co. Ltd. The inventors Qinglin Song, Dewen Tian, and Haisheng Wang filed the patent on December 6, 2019 and published it online on August 27, 2024. Also mentioned are background information supplied by the inventors, inventors' summary information for the patent, and the claims supplied by the inventors.

A patent application has been submitted for a device and method for analyzing a gaseous sample, specifically focusing on the measurement of fine quartz dust content in the air. The invention aims to provide a device that can be carried by workers on construction sites to determine their exposure to quartz dust throughout the day. The device uses Raman scattering to analyze the particles in the sample and evaluate their composition. It is designed to be robust, easy to operate, and capable of distinguishing between different forms of silicon dioxide. The patent application provides detailed descriptions of the components and methods involved in the device. [Extracted from the article]

A study conducted by the Department of Mechanical Engineering in Bhagalpur, India, explored the use of silicon dioxide nanoparticles in dental composites. The researchers found that the addition of 10 weight-% of these nanoparticles improved the mechanical and viscoelastic properties of the composites, increasing micro-hardness by 126.1%, compressive strength by 7.6%, and flexural strength by 28.8%. However, physical properties such as void content and water sorption were increased by 10% and 25% respectively. The study was peer-reviewed and provides valuable insights into the potential benefits of using nanoparticles in dental materials. [Extracted from the article]

A new study conducted at the Universidad del Atlantico explores the use of lyophilized polyvinyl alcohol and chitosan scaffolds pre-loaded with silicon dioxide nanoparticles for tissue regeneration. The researchers found that these materials have a soft tissue regenerative capacity and can promote tissue growth and proliferation. The scaffolds also demonstrated good biocompatibility and antimicrobial properties. The study highlights the important role of nanoparticles in optimizing scaffold properties and expanding the boundaries of tissue engineering and regenerative medicine. [Extracted from the article]

Researchers from Villanova University have developed a new dialysis-leaching test (DLT) method for measuring the diffusion properties of clayey materials, specifically bentonite-based barrier materials. This method is relatively simple, time-efficient, and can be performed independently by an undergraduate student. The research found that the experimental results were reproducible between two independent laboratories and compared favorably to data measured with existing diffusion test methods. This study provides valuable information for modeling the performance of engineered containment barriers and was supported by the National Science Foundation. [Extracted from the article]

A patent application for the use of bempedoic acid in the treatment of cardiovascular diseases has been made available online. The application discusses the need for alternative therapies to reduce low-density lipoprotein-cholesterol (LDL-C) levels, as many patients experience adverse side effects from statins. The inventors propose using bempedoic acid to reduce the risk of major adverse cardiovascular events and lower LDL-C levels in high-risk patients. The method involves administering a daily dose of 180 mg of bempedoic acid in a pharmaceutical formulation. [Extracted from the article]

A patent has been issued for a system and method for a transistor pathogen detector developed by Akhan Semiconductor Inc. The invention aims to provide a practical and efficient method for detecting pathogen viruses, including the SARS-COV2 virus responsible for COVID-19. The detector utilizes a substrate layer, silicon dioxide layer, nanocrystalline diamond layer, graphene oxide layer, fluorinated graphene oxide portions, and a linker layer with pathogen receptors. The system functions as a biosensor field effect transistor and offers potential advancements in the field of pathogen detection. [Extracted from the article]

A patent application titled "Methods Of Treatment Using Bempedoic Acid" has been published online. The inventors propose using bempedoic acid to reduce the risk of myocardial infarction, coronary revascularization, and low-density lipoprotein cholesterol (LDL-C) in adults with cardiovascular disease or risk factors. The method involves orally administering a pharmaceutical formulation containing 180 mg of bempedoic acid and other excipients. The patent application also mentions the possibility of combining bempedoic acid with other LDL-C-lowering therapies. This information may be useful for researchers studying cardiovascular diseases and therapies. [Extracted from the article]

A recent study conducted at the University of Bremen in Germany explores the potential use of zeolites as carrier materials for the controlled release of the anticancer drug 5-fluorouracil (5-FU). The researchers used density functional theory calculations and ab initio molecular dynamics simulations to investigate the interaction between 5-FU and faujasite-type zeolites with different Si/Al ratios. They found that the presence of multiple protons in the zeolite framework enhances the adsorption energy of 5-FU, and that the high affinity of water to the framework protons can trigger the release of 5-FU. This research provides valuable insights into the storage and release mechanisms of 5-FU in zeolites, which could have implications for drug delivery applications. [Extracted from the article]

A study conducted by researchers at Nankai University in Tianjin, China, focused on the analysis of acid sites in zeolites, which are important catalysts in acid catalytic reactions. The researchers used a combination of probe-assisted nuclear magnetic resonance (NMR) spectroscopy and temperature programmed desorption of ammonia (NH3-TPD) to determine the acid type, density, and strength in different zeolites. They found that the desorption temperature of NH3 probe molecules could determine the acid type and density, while CD3CN probe-assisted NMR spectroscopy could investigate the acid strength. This research provides valuable insights into the characterization of acid sites in zeolites. [Extracted from the article]

A patent application has been submitted for a hydrocortisone acetate suppository formulation for the treatment of gastrointestinal diseases such as ulcerative colitis, Crohn's disease, and inflammatory bowel disease. The formulation aims to provide a safer and more effective treatment option compared to current rectal drug formulations of hydrocortisone. The suppository formulation includes hydrocortisone acetate, colloidal silicon dioxide, and an oleaginous base. The invention also includes alternative configurations of suppositories and drug delivery systems that improve drug delivery and patient comfort. [Extracted from the article]

A patent application titled "Hydrocortisone Acetate Suppository Formulation For Treatment Of Disease" has been published online. The inventors have developed a formulation of hydrocortisone acetate that is suitable for administration as a suppository to treat gastrointestinal diseases, including ulcerative colitis. The formulation contains hydrocortisone acetate and colloidal silicon dioxide, and may also include an oleaginous base and butylated hydroxytoluene. The inventors have also proposed alternative configurations for the suppository, such as a ring or tree shape, as well as other drug delivery systems. The formulation and suppository designs aim to improve patient retention, reduce absorption variability, and enhance drug delivery. [Extracted from the article]

A patent application has been filed for a new suppository formulation of hydrocortisone acetate for the treatment of gastrointestinal diseases such as ulcerative colitis, Crohn's disease, and inflammatory bowel disease. The formulation contains hydrocortisone acetate and colloidal silicon dioxide, and it is designed to have improved retention and reduced absorption variability compared to current suppository formulations. The suppository can be administered using various shapes, including a ring or tree shape, and it can be combined with an insertion device for ease of use. The invention aims to provide a safer and more effective treatment option for these diseases. [Extracted from the article]

A patent application has been filed for a new formulation of hydrocortisone acetate suppositories for the treatment of gastrointestinal diseases such as ulcerative colitis, Crohn's disease, and inflammatory bowel disease. The formulation contains hydrocortisone acetate and colloidal silicon dioxide, and may also include an oleaginous base and butylated hydroxytoluene. The suppositories have a weight of 2 grams and release at least 80% of the hydrocortisone acetate within 180 minutes. The invention also includes alternative configurations of suppositories and other drug delivery systems, such as rings, trees, fabrics, and sponges, to improve drug delivery and contact with the rectal lining. [Extracted from the article]

A patent application titled "Hydrocortisone Acetate Suppository Formulation For Treatment Of Disease" has been published online. The inventors propose a new formulation of hydrocortisone suppositories for the treatment of gastrointestinal diseases such as ulcerative colitis and Crohn's disease. The formulation includes hydrocortisone acetate and colloidal silicon dioxide, and it has advantages over current suppository formulations, including improved patient retention and reduced absorption variability. The inventors also describe alternative configurations of suppositories and other drug delivery systems that can enhance drug delivery and improve patient comfort. [Extracted from the article]

Researchers from Burdur Mehmet Akif Ersoy University in Turkey have conducted a study on the synthesis and characterization of biopolymer-clay composite films for potential food packaging material. The films were created using chitosan and either silver-loaded organo-bentonite or organo-bentonite. The films exhibited enhanced properties such as thermal stability, UV-visible light barrier, and antibacterial properties against various bacteria. The researchers concluded that the chitosan-based film reinforced with these composites has potential for food preservation and packaging. [Extracted from the article]

According to a report by Future Market Insights, the global bentonite clay market is expected to reach USD 1.9 billion in 2024 and USD 3.2 billion by 2034, with a projected growth rate of 5.2% by 2034. Bentonite clay is being increasingly used in cosmetic preparations and pharmaceuticals as pigment binders and suspending agents. The foundry and metal casting industries, particularly in the automobile and equipment manufacturing sectors, are also driving the demand for bentonite clay. The industry is further influenced by its usage as groundwater barriers, binders in iron and steel manufacturing, liquor clarifiers, and high drilling mud applications. The market is positively affected by factors such as the increased use of iron ore pellets in steel manufacturing, high demand from automotive industries, and growing awareness among users. [Extracted from the article]

Researchers at the University of Toronto Scarborough have conducted a study analyzing the natural organic matter (NOM) composition in bentonite clay under different dry densities and durations. The study found that the carbon content and NOM composition did not significantly vary across bentonite samples with different compaction densities or durations. The research suggests that compacted bentonite exhibits geochemical stability under simulated repository environments, providing valuable insights for the design and performance of engineered barrier systems in a Deep Geological Repository (DGR) concept. The study was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Nuclear Waste Management Organization. [Extracted from the article]

A recent report from Gansu Provincial Maternity and Child-care Hospital in Lanzhou, China, discusses the development of a mild and eco-friendly method for preparing kaolin-decorated gold nanoparticles (Au NPs) using Ephedra root extract as a green reducing and stabilizing agent. The structural features of the Au NPs/Kaolin were assessed using various techniques. The researchers found that the bio-nanocomposite showed antioxidant efficacy and demonstrated cytotoxicity against human ovarian carcinoma cells. In an in vivo study, the bio-nanocomposite ameliorated symptoms of adenomyosis in mice by modulating the MAPK/ERK signaling pathway and reducing inflammatory factors. The research suggests potential applications for the management of ovarian cancer and adenomyosis. [Extracted from the article]

A study conducted at Federal University Paraiba in Joao Pessoa, Brazil, has explored the use of calcium bentonite as a delivery carrier for an antihypertensive drug called amiloride hydrochloride. The researchers found that the drug could be successfully adsorbed onto the calcium bentonite, and the resulting hybrid exhibited controlled release properties. The study also confirmed the biocompatibility of the system. The findings suggest that calcium bentonite shows promise as a drug delivery system. [Extracted from the article]

A recent study conducted at Tel Aviv University in Israel explores the potential of a gelatin-alginate-based hydrogel, cross-linked with a carbodiimide, and loaded with two functional fillers, kaolin and cellulose fibers, to improve the mechanical strength and hemostatic properties of the hydrogel for use as a sealant. The study found that the incorporation of these fillers resulted in enhanced sealing ability, tensile strength, and Young's modulus compared to the unloaded hydrogel formulation. The cellulose fibers were found to have a more dominant effect on the mechanical properties than kaolin. The researchers concluded that these new dual micro-composite hydrogels may be suitable for medical sealing applications, especially when a high sealing effect is needed within a short time. The study also found that the inclusion of kaolin did not affect the physical properties of the sealant. [Extracted from the article]

A recent report from Jiangsu University in Zhenjiang, China discusses research on the deactivation mechanism of Cu-based zeolites for NH3-SCR by hydrocarbons deposition species. The study focused on four different zeolites (AEI, SSZ-13, ZSM-5, and BEA) and their resistance to hydrocarbons. The results showed that SSZ-13 had better resistance than AEI, and the hydrocarbons species on the catalyst surface varied depending on the zeolite. The research concluded that when a large number of copper sites were covered by hydrocarbons, the zeolite catalysts showed better low-temperature activity. This research has been peer-reviewed and provides valuable insights into fuel research. [Extracted from the article]