1. The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors.
- Author
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Zhu J, Xiong Y, Zhang Y, Wen J, Cai N, Cheng K, Liang H, and Zhang W
- Subjects
- Acetaminophen pharmacology, Antineoplastic Agents pharmacology, Antioxidants metabolism, Apoptosis, Artemisinins metabolism, Auranofin pharmacology, Cell Death, Cisplatin pharmacology, Epigenesis, Genetic, Fatty Acids metabolism, Haloperidol pharmacology, Humans, Indoles administration & dosage, Iron metabolism, Lapatinib administration & dosage, Mevalonic Acid metabolism, NADP metabolism, Oxidation-Reduction, Oxygen metabolism, Quinolines pharmacology, Reactive Oxygen Species, Sorafenib pharmacology, Spiro Compounds administration & dosage, Sulfasalazine pharmacology, Trigonella metabolism, Ferroptosis, Neoplasms metabolism, Oxidative Stress
- Abstract
Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the antioxidant system's failure. The sensitivity of ferroptosis is tightly regulated by a series of biological processes, the metabolism of iron, amino acids, and polyunsaturated fatty acids, and the interaction of glutathione (GSH), NADPH, coenzyme Q10 (CoQ10), and phospholipids. Elevated oxidative stress (ROS) level is a hallmark of cancer, and ferroptosis serves as a link between nutrition metabolism and redox biology. Targeting ferroptosis may be an effective and selective way for cancer therapy. The underlying molecular mechanism of ferroptosis occurrence is still not enough. This review will briefly summarize the process of ferroptosis and introduce critical molecules in the ferroptotic cascade. Furthermore, we reviewed the occurrence and regulation of reduction-oxidation (redox) for ferroptosis in cancer metabolism. The role of the tumor suppressor and the epigenetic regulator in tumor cell ferroptosis will also be described. Finally, old drugs that can be repurposed to induce ferroptosis will be characterized, aiming for drug repurposing and novel drug combinations for cancer therapy more efficiently and economically., Competing Interests: The authors declare no conflict of interest, financial, or otherwise., (Copyright © 2020 Jinghan Zhu et al.)
- Published
- 2020
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