1. Oxidative Stress Profile of Mothers and Their Offspring after Maternal Consumption of High-Fat Diet in Rodents: A Systematic Review and Meta-Analysis.
- Author
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Moraes-Souza RQ, Vesentini G, Paula VG, Sinzato YK, Soares TS, Gelaleti RB, Volpato GT, and Damasceno DC
- Subjects
- Animals, Female, Mice, Pregnancy, Rats, Rodentia, Diet, High-Fat adverse effects, Oxidative Stress physiology
- Abstract
Maternal exposure to the high-fat diet (HFD) during gestation or lactation can be harmful to both a mother and offspring. The aim of this systematic review was to identify and evaluate the studies with animal models (rodents) that were exposed to the high-fat diet during pregnancy and/or lactation period to investigate oxidative stress and lipid and liver enzyme profile of mothers and their offspring. The electronic search was performed in the PUBMED (Public/Publisher MEDLINE), EMBASE (Ovid), and Web of Science databases. Data from 77 studies were included for qualitative analysis, and of these, 13 studies were included for meta-analysis by using a random effects model. The pooled analysis revealed higher malondialdehyde levels in offspring of high-fat diet groups. Furthermore, the pooled analysis showed increased reactive oxygen species and lower superoxide dismutase and catalase in offspring of mothers exposed to high-fat diet during pregnancy and/or lactation. Despite significant heterogeneity, the systematic review shows oxidative stress in offspring induced by maternal HFD., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2021 R. Q. Moraes-Souza et al.)
- Published
- 2021
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