1. Effects of lamotrigine on behavior, oxidative parameters and signaling cascades in rats exposed to the chronic mild stress model.
- Author
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Abelaira HM, Réus GZ, Ribeiro KF, Steckert AV, Mina F, Rosa DV, Santana CV, Romano-Silva MA, Dal-Pizzol F, and Quevedo J
- Subjects
- Amygdala drug effects, Amygdala metabolism, Analysis of Variance, Animals, Calcium Channel Blockers therapeutic use, Catalase metabolism, Chronic Disease, Disease Models, Animal, Food Preferences drug effects, Lamotrigine, Male, Malondialdehyde metabolism, Protein Carbonylation drug effects, Proto-Oncogene Proteins c-akt metabolism, Rats, Rats, Wistar, Stress, Psychological drug therapy, Sucrose administration & dosage, Superoxide Dismutase metabolism, Sweetening Agents administration & dosage, Thiobarbituric Acid Reactive Substances metabolism, Triazines therapeutic use, Calcium Channel Blockers pharmacology, Exploratory Behavior drug effects, Oxidative Stress drug effects, Signal Transduction drug effects, Stress, Psychological physiopathology, Triazines pharmacology
- Abstract
The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine showed an increase on malondialdehyde equivalents (MDA) in the prefrontal cortex, and that there was also an increase in the amygdala of the control rats treated with lamotrigine. The carbonyl protein was increased in the prefrontal cortex of the stressed group treated with saline, however, the lamotrigine treatment reversed this effect. The treatment with lamotrigine increased the superoxide dismutase (SOD) and catalase activity (CAT) activities in the amygdala of stressed rats. The protein kinase B (PKB/Akt) was reduced in the amygdala in the stressed group treated with saline or lamotrigine. We suggest that the antidepressant-like effect of lamotrigine on anhedonic behavior may be related at least in part to its effects on the oxidative stress parameters and AKT., (Copyright © 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.) more...
- Published
- 2013
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