1. The impact of different biocompatible coated cardiopulmonary bypass circuits on inflammatory response and oxidative stress.
- Author
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Sohn N, Marcoux J, Mycyk T, Krahn J, and Meng Q
- Subjects
- Aged, Female, Humans, Inflammation blood, Inflammation etiology, Interleukin-10 agonists, Interleukin-10 blood, Interleukin-6 agonists, Interleukin-6 blood, Male, Middle Aged, Nitric Oxide antagonists & inhibitors, Nitric Oxide blood, Peroxidase blood, Peroxidase drug effects, Tumor Necrosis Factor-alpha agonists, Tumor Necrosis Factor-alpha blood, Cardiopulmonary Bypass adverse effects, Coated Materials, Biocompatible administration & dosage, Coronary Artery Bypass adverse effects, Inflammation prevention & control, Myocardial Infarction surgery, Oxidative Stress drug effects
- Abstract
This study was to compare the impact of different biocompatible coated circuits on inflammatory response and oxidative stress induced during cardiopulmonary bypass (CPB). Seventy-eight patients undergoing elective coronary artery bypass grafting (CABG) with CPB were randomly assigned to five groups with different biocompatible coated circuits: Trillium, Bioline, Phosphorylcholine, Polymethoxyethyl acrylate (PMEA), and the uncoated control group. Blood was drawn at three different time points: before CPB, 6 and 72 hours post CPB. Unlike the Trillium group, serum levels of TNF-alpha in the Bioline and Phosphorylcholine groups significantly increased only at 72 hours post CPB (p < 0.05). Serum levels of IL-6 significantly increased at 6 and 72 hours post CPB in all groups (p < 0.01). The Trillium group showed a significant increase of IL-10 compared to the control group at 72 hours post CPB (p < 0.05). Serum levels of NOx in the Phosphorylcholine group significantly decreased at 6 hours post CPB compared to baseline (p < 0.05). Both the Bioline and Phosphorylcholine groups showed statistical decreases in serum NOx levels compared with other groups at 6 hours post CPB (p < 0.05). A significant difference in NOx levels between the Bioline and the control group was also observed at 72 hours post CPB. Myeloperoxidase levels were significantly elevated at 6 and 72 hours post CPB in all groups (p < 0.05). Inflammatory response and oxidative stress are elevated during CABG with CPB. Heparin-coated and the Phosphorylcholine-coated circuits induce less inflammatory responses and oxidative stress compared to other circuits.
- Published
- 2009
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