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Your search keyword '"Karincaoglu M"' showing total 3 results
Start Over Author "Karincaoglu M" Topic oxidative stress
3 results on '"Karincaoglu M"'

1. Gastric tissue oxidative changes in portal hypertension and cirrhosis.

Author

Seckin Y, Harputluoglu MM, Batcioglu K, Karincaoglu M, Yildirim B, Oner RI, Uyumlu B, Aydogdu N, and Hilmioglu F

Subjects
Adult, Aged, Case-Control Studies, Catalase metabolism, Female, Gastric Mucosa enzymology, Gastric Mucosa microbiology, Gastric Mucosa pathology, Gastroscopy, Glutathione Peroxidase metabolism, Helicobacter pylori isolation & purification, Humans, Hypertension, Portal enzymology, Hypertension, Portal microbiology, Hypertension, Portal pathology, Liver Cirrhosis enzymology, Liver Cirrhosis microbiology, Liver Cirrhosis pathology, Male, Malondialdehyde metabolism, Middle Aged, Portal Vein pathology, Prospective Studies, Spleen pathology, Superoxide Dismutase metabolism, Gastric Mucosa metabolism, Hypertension, Portal metabolism, Liver Cirrhosis metabolism, Oxidative Stress
Abstract

Gastric mucosal lesions are very common in portal hypertension and cirrhosis. The aim of this study was to assess for oxidative gastric tissue damage in cirrhosis and evaluate relations with portal hypertension and cirrhosis parameters. The study included 30 patients with cirrhosis and 30 controls. Each patient's history, physical examination, and laboratory findings were recorded, and multiple biopsies of the gastric antrum were obtained at endoscopy. A set of antral biopsies was also collected from each control subject. Each tissue specimen was analyzed for levels of glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) activity and level of malondialdehyde (MDA). Patients' gastric GPX, SOD, and CAT levels were significantly lower, and MDA levels were higher, than in the control group. The GPX activity level in the specimens was moderately negatively correlated with portal vein diameter (P<0.05, r=-0.45) and spleen length (P<0.05, r=-0.45). In this study gastric tissue oxidative markers showed that antral oxidative factors worsen in cirrhosis. Oxidative stress may not be a clinical condition but it obviously shows gastric tissue damage and may explain many patients' gastric lesions and hemorrhage.

Published
2007
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2. Protective effects of Gingko biloba on thioacetamide-induced fulminant hepatic failure in rats.

Author

Harputluoglu, M. M. M., Demirel, U., Ciralik, H., Temel, I., Firat, S., Ara, C., Aladag, M., Karincaoglu, M., and Hilmioglu, F.

Subjects
LIVER failure, GINKGO, OXIDATIVE stress, PLATELET activating factor, ACETAMIDE, ANTIOXIDANTS, LABORATORY rats, THERAPEUTICS
Abstract

Gingko biloba (GB) has antioxidant and platelet-activating factor (PAF) antagonistic effects. We investigated the protective effects of GB on thioacetamide (TAA)-induced fulminant hepatic failure in rats. Fulminant hepatic failure was induced in treatment groups by three intraperitoneal (ip) injections of TAA (350 mg/kg) at 24-hour intervals. Treatments with GB (100 mg/kg per day, orally) and N-acetylcysteine (20 mg/kg twice daily, sc) were initiated 48 hours prior to TAA administration. The liver was removed for histopathological examinations. Serum and liver thiobarbituric acid-reactive substance (TBARS) levels were measured for assessment of oxidative stress. Liver necrosis and inflammation scores and serum and liver TBARS levels were significantly higher in the TAA group compared to the control group (P <0.001, <0.001, 0.001, <0.001, respectively). Liver necrosis and inflammation scores and liver TBARS levels were significantly lower in the GB group compared to the TAA group (P <0.001, <0.001 and 0.01, respectively). GB ameliorated hepatic damage in TAA-induced fulminant hepatic failure. This may be due to the free radical-scavenging effects of GB. [ABSTRACT FROM AUTHOR]

Published
2006
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3. The effects of Gingko biloba, vitamin E and melatonin on bacterial translocation in thioacetamide-induced fulminant hepatic failure in rats

Author

Murat Harputluoglu, Demirel U, Karadag N, Temel I, Bayraktar M, Firat S, Karahan D, Aladag M, Alan H, Ates F, Karincaoglu M, and Hilmioglu F

Subjects
Male, Analysis of Variance, Ginkgo biloba, Liver Failure, Acute, Thioacetamide, Thiobarbituric Acid Reactive Substances, Antioxidants, Rats, Intestines, Survival Rate, Disease Models, Animal, Oxidative Stress, Bacterial Translocation, Escherichia coli, Animals, Vitamin E, Mesentery, Lipid Peroxidation, Lymph Nodes, Plant Preparations, Intestinal Mucosa, Biomarkers, Spleen, Melatonin, Phytotherapy
Abstract

Bacterial translocation (BT) has been implicated in the development of infectious complications in many serious clinical conditions such as fulminant hepatic failure (FHF). We aimed to investigate the effects of Gingko biloba (GB), vitamin E (Vit E) and melatonin on intestinal oxidative damage and BT in thioacetamide (TAA)-induced FHF in rats.A total of 42 rats were divided into five groups. Group 1 (n = 8) was the control group. Group 2 (n = 10) was the TAA group, in which rats received 350 mg/kg TAA daily by the intraperitoneal (ip) route for 3 days. Oral 100 mg/kg GB per day was administered to group 3 (n = 8), oral 200 mg/kg Vit E per day to group 4 (n = 8) and ip 3 mg/kg melatonin per day to group 5 (n = 8) 48 h prior to the first TAA injection and was continued for 5 consecutive days.When compared with the control group, serious hepatic and intestinal oxidative damage, increased Escherichia coli counts in ileal aspirates and high BT frequencies were observed in the TAA group (all p0.0001). Only GB treatment attenuated hepatic oxidative damage (p0.0001). There was no difference in intestinal oxidative damage, E. coli counts in ileal aspirates and BT frequency between TAA and the other antioxidant treatment groups (p0.05).Our results suggest that intestinal oxidative damage plays a major role in the development of BT by disrupting the barrier function of intestinal mucosa.

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