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Objective: To investigate serum prolidase activity and oxidative stress in patients with temporomandibular joint internal derangement (TMJ-ID).Methods: Seventy patients with Wilkes stage III, IV, and V joints and 70 healthy controls were included. Serum prolidase activity and oxidative stress parameters, including total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), advanced oxidation protein products (AOPP), glutathione (GSH), ferric reducing antioxidant power (FRAP), and lipid hydroperoxide (LOOH) were measured.Results: The levels of prolidase, TOS, OSI, AOPP, and LOOH were significantly higher in the TMJ-ID group than in the control (p = .0001). TAS and FRAP level was significantly lower in the TMJ-ID group than in the control (p = .0001). There was no significant difference in GSH between groups.Conclusion: Significantly increased prolidase activity and oxidative stress in patients with TMJ-ID may be related to long-term collagen tissue damage, and inflammation and can be effective in the etiology of TMJ-ID. [ABSTRACT FROM AUTHOR]

Aim: In this study, we aim to investigate the effects of supplementary Grape Seed Extract (GSE) and Low-Level Laser Therapy (LLLT) on fracture healing, oxidant and anti-oxidant system in experimental mandible fractures. Materials and Methods: 48 Wistar Albino rats (adult male, n=48) were used in our study. For all the subjects, a vertical fracture line through molar teeth in right mandibles was created and internally fixed using a four-hole microplate and four micro screws. Firstly, these subjects were randomly divided into 4 main groups (Control, GSE, LLLT, GSE+LLLLT) of 12 animals each, and then these were individually separated into two sub-groups of 7th and 21st days. The number of groups (n=6) was 8 in total. GSE of 300 mg/kg/ day were provided to the subjects before they were sacrificed. LLLT of 23 J/cm2 was administered to two different points along with the fracture line at intervals of 48 hours for 7 days in the 7th day sub-groups and for 14 days in the 21st day sub-groups. After the procedure, while biochemical values such as TAS, TOS and OSI are measured; histopathologically it was examined in terms of capillary number and width, inflammatory cell, fibroblast count, collagen fibers, osteoblast count, ossification and mature bone formations. Results: For biochemical analyses, there was statistically significant difference only in TAS values on either the 7th or 21st day for the groups. Histological analyses showed that mandibular fracture healing were significantly better in the GSE and GSE+LLLT groups compared to the control group. The group of only LLLT had limited recovery while the combination of GSE+LLLT was the best for ossification. Conclusions: It is concluded that GSE may be one of the potential methods to accelerate fracture healings in mandibular fractures common in oral and maxillofacial surgery clinic and thus help patients recover in shorter time, and however LLLT can have positive effects on the process of ossification and recovery only when combined with the extract, which may result in better outcomes in clinical use. [ABSTRACT FROM AUTHOR]

Aim: The present study investigated the changes in the liver tissues of rats with experimentally fractured mandible following the use of Grape Extract (GSE) and Low Level Laser Therapy (LLLT) in healing the fracture in dentistry. Materials and Methods: 60 adult male Wistar Albino rats were randomly assigned to 5 main groups (Control, Fractured Mandible (FM), FM + GSE, FM + LLLT, FM + LLLT + GSE), and then these groups were divided into two groups of 7 and 21 days (n = 6). A vertical fracture line passing through the molar teeth was formed in the right mandibles of all subjects except for these in the control group, and the fracture was internally fixed with a four-hole microplate and four micro-screws. Malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) activities were analyzed to determine the changes caused by GSE and LLLT administration in rat liver tissues in fractured mandibles. Results: It was determined that MDA and SOD levels in FM group and GSH and CAT activity levels in FM + GSE group and MDA levels in FM + LLLT group and GSH and CAT levels in FM + GSE + LLLT group increased statistically significantly to the control group on days 7 and 21. Conclusion: Biochemical parameters were investigated on the 7th and the 21st days, and it was determined that the oxidative damage caused by mandibular defects could be eliminated substantially in the rat liver especially with the administration of grapeseed that has antioxidant capacity. [ABSTRACT FROM AUTHOR]