1. Nattokinase as an adjuvant therapeutic strategy for non-communicable diseases: a review of fibrinolytic, antithrombotic, anti-inflammatory, and antioxidant effects.
- Author
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Granito M, Alvarenga L, Ribeiro M, Carvalhosa P, Andrade T, Mesquita CT, Stockler-Pinto MB, Mafra D, and Cardozo LF
- Subjects
- Humans, Animals, Noncommunicable Diseases drug therapy, Fibrinolytic Agents therapeutic use, Fibrinolytic Agents pharmacology, Subtilisins, Antioxidants therapeutic use, Antioxidants pharmacology, Oxidative Stress drug effects, Anti-Inflammatory Agents therapeutic use, Anti-Inflammatory Agents pharmacology, Inflammation drug therapy, Cardiovascular Diseases prevention & control, Cardiovascular Diseases drug therapy
- Abstract
Introduction: Nattokinase (NK) is the primary ingredient of natto, a traditional Asian food made from fermented soybean by Bacillus subtilis natto . Studies have shown that natto reduces the risk of cardiovascular disease (CVD) mortality due to its fibrinolytic and antithrombotic properties. A new field of studies also demonstrates that NK can mitigate molecular pathways related to inflammation and oxidative stress and can be considered an adjuvant strategy for use in many non-communicable diseases (NCDs). This paper is a narrative review of the literature. A search was conducted in PubMed and ScienceDirect up to July 2024., Areas Covered: This review discusses the possible effects of NK on mitigating the common complications of NCDs, such as inflammation and oxidative stress. In addition, it provides an update on the most addressed areas related to NK's fibrinolytic and antithrombotic activities., Expert Opinion: Due to the fibrinolytic and antithrombotic activity of nattokinase, and more recently added to the anti-inflammatory and antioxidant effects, this enzyme can be used as a new adjuvant therapeutic strategy to mitigate inflammation and oxidative stress in NCDs, including CVD.
- Published
- 2024
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