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Start Over Author "Alto LE" Topic oxidative phosphorylation
2 results on '"Alto LE"'

1. Effects of pentobarbital and pentothal on rat heart contractile force and oxidative phosphorylation activities.

Author

Bhayana V, Alto LE, and Dhalla NS

Subjects
Animals, Calcium metabolism, Depression, Chemical, Dose-Response Relationship, Drug, In Vitro Techniques, Male, Mitochondria drug effects, Mitochondria metabolism, Oxygen Consumption drug effects, Rats, Sarcolemma drug effects, Sarcolemma metabolism, Barbiturates pharmacology, Myocardial Contraction drug effects, Oxidative Phosphorylation drug effects, Pentobarbital pharmacology, Thiopental pharmacology
Published
1980
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2. Effects of some antiarrhythmic agents on dog heart mitochondrial oxidative phosphorylation.

Author

Alto LE and Dhalla NS

Subjects
Adenosine Diphosphate metabolism, Animals, Dogs, In Vitro Techniques, Lidocaine pharmacology, Mitochondria, Heart drug effects, Oxygen Consumption drug effects, Procainamide pharmacology, Quinidine pharmacology, Anti-Arrhythmia Agents pharmacology, Mitochondria, Heart metabolism, Oxidative Phosphorylation drug effects
Abstract

Significant decreases in state 3 oxygen consumption, respiratory control index (RCI), ADP : O ratio and phosphorylation rate were observed in the presence of 0.1-1.0 mM quinidine; 0.5 mM or greater concentrations elevated state 4 oxygen consumption. Lidocaine (1-2.5 mM) also depressed RCI and increased state 4 oxygen consumption but procaine amide (1-2.5 mM) was without effect. It is suggested that cardiodepression by quinidine may be associated with its ability to impair mitochondrial metabolism.

Published
1979
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