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Your search keyword '"Xiaoqi Zhou"' showing total 4 results
Start Over Author "Xiaoqi Zhou" Topic oxidant stress
4 results on '"Xiaoqi Zhou"'

1. Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet

Author

Qingde Huang, Xiaoqi Zhou, Jiqu Xu, Jine Yang, Qianchun Deng, and Fenghong Huang

Subjects
Male, Rapeseed, Antioxidant, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Drug Evaluation, Preclinical, Tocopherols, Antioxidants, Lipid peroxidation, Fatty Acids, Monounsaturated, Rats, Sprague-Dawley, chemistry.chemical_compound, Endocrinology, Risk Factors, Plasma lipids, Rapeseed oil, Food science, Micronutrients, lcsh:RC620-627, medicine.diagnostic_test, Phytosterols, Micronutrient, Catalase, Glutathione, Lipids, lcsh:Nutritional diseases. Deficiency diseases, C-Reactive Protein, Biochemistry, Food, Fortified, Lipidology, Clinical chemistry, Thiobarbituric Acid Reactive Substances, medicine, Animals, Plant Oils, Enzyme Assays, Biochemistry, medical, Inflammation, Glutathione Peroxidase, Cholesterol, Interleukin-6, Superoxide Dismutase, Research, Biochemistry (medical), Cholesterol, HDL, Polyphenols, Cholesterol, LDL, Atherosclerosis, Dietary Fats, Rats, chemistry, Lipid Peroxidation, Oxidant stress, Lipid profile
Abstract

Background Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet. Methods The rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified refined rapeseed oil with low, middle and high quantities of these micronutrients (L-, M- and H-FRRO). Forty male SD rats were divided into four groups. One group received RRO diet and other groups received L-, M- and H-FRRO diet for 10 weeks. Results Micronutrients supplementation significantly increased plasma antioxidant defense capacities, as evaluated by the significant elevation in the activities of GPx, CAT and SOD as well as the level of GSH, and the significant decline in lipid peroxidation. These micronutrients also reduced the plasma contents of TG, TC and LDL-C and increased the ratio of HDL-C/LDL-C. In addition, in parallel with the enhancement of these micronutrients, plasma levels of IL-6 and CRP declined remarkably. Conclusion Rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent atherogenesis by ameliorating plasma oxidative stress, lipid profile and inflammation.

Published
2011

2. Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet.

Author

Jiqu Xu, Xiaoqi Zhou, Hui Gao, Chang Chen, Qianchun Deng, Qingde Huang, Jing Ma, Zhengyang Wan, Jin'e Yang, and Fenghong Huang

Subjects
*RAPESEED oil, *HIGH-fat diet, *OXIDATIVE stress, *LIPID peroxidation (Biology), *FATTY liver, *BLOOD cholesterol, *FATTY degeneration
Abstract

Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to hepatoprotection, but most of these micronutrients are removed by the traditional refining process. The purpose of the present study was to determine whether rapeseed oil fortified with these micronutrients can decrease hepatic lipid accumulation and oxidative stress induced by high-fat diet. Sprague-Dawley rats received rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified RRO with low, middle and high quantities of these micronutrients for 10 weeks. Intake of RRO caused a remarkable hepatic steatosis. Micronutrients supplementation was effective in reducing steatosis as well as total triglyceride and total cholesterol contents in liver. These micronutrients also significantly increased hepatic antioxidant defense capacities, as evaluated by the significant elevation in the activities of SOD and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. These findings suggest that rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent fatty livers such as nonalcoholic fatty liver disease by ameliorating hepatic lipid accumulation and oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2013
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3. Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet.

Author

Jiqu Xu, Xiaoqi Zhou, Qianchun Deng, Qingde Huang, Jin'e Yang, and Fenghong Huang

Subjects
*RAPESEED oil, *MICRONUTRIENTS, *LABORATORY rats, *BLOOD circulation, *CARDIOVASCULAR system
Abstract

Background: Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet. Methods: The rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified refined rapeseed oil with low, middle and high quantities of these micronutrients (L-, M- and H-FRRO). Forty male SD rats were divided into four groups. One group received RRO diet and other groups received L-, M- and H-FRRO diet for 10 weeks. Results: Micronutrients supplementation significantly increased plasma antioxidant defense capacities, as evaluated by the significant elevation in the activities of GPx, CAT and SOD as well as the level of GSH, and the significant decline in lipid peroxidation. These micronutrients also reduced the plasma contents of TG, TC and LDL-C and increased the ratio of HDL-C/LDL-C. In addition, in parallel with the enhancement of these micronutrients, plasma levels of IL-6 and CRP declined remarkably. Conclusion: Rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent atherogenesis by ameliorating plasma oxidative stress, lipid profile and inflammation. [ABSTRACT FROM AUTHOR]

Published
2011
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4. Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet

Author

Jiqu Xu, Xiaoqi Zhou, Qingde Huang, Jine Yang, Chang Chen, Jing Ma, Qianchun Deng, Zhengyang Wan, Hui Gao, and Fenghong Huang

Subjects
Male, Antioxidant, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Tocopherols, Lipid accumulation, Biology, medicine.disease_cause, Diet, High-Fat, Antioxidants, Lipid peroxidation, Fatty Acids, Monounsaturated, Rats, Sprague-Dawley, chemistry.chemical_compound, Endocrinology, Nonalcoholic fatty liver disease, medicine, Animals, Plant Oils, Food science, Micronutrients, Triglycerides, Biochemistry, medical, Triglyceride, Superoxide Dismutase, Research, Biochemistry (medical), Polyphenols, Phytosterols, Lipid metabolism, Micronutrient, medicine.disease, Lipid Metabolism, Oxidative Stress, chemistry, Biochemistry, Liver, Food, Fortified, Rapeseed Oil, Lipid Peroxidation, Steatosis, Oxidant stress, Oxidative stress
Abstract

Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to hepatoprotection, but most of these micronutrients are removed by the traditional refining process. The purpose of the present study was to determine whether rapeseed oil fortified with these micronutrients can decrease hepatic lipid accumulation and oxidative stress induced by high-fat diet. Sprague–Dawley rats received rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified RRO with low, middle and high quantities of these micronutrients for 10 weeks. Intake of RRO caused a remarkable hepatic steatosis. Micronutrients supplementation was effective in reducing steatosis as well as total triglyceride and total cholesterol contents in liver. These micronutrients also significantly increased hepatic antioxidant defense capacities, as evaluated by the significant elevation in the activities of SOD and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. These findings suggest that rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent fatty livers such as nonalcoholic fatty liver disease by ameliorating hepatic lipid accumulation and oxidative stress.

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