1. Modular synthesis of oxazolines and their derivatives.
- Author
-
Mei L, Hai ZJ, Jie S, Ming ZS, Hao Y, and Liang HK
- Subjects
- Combinatorial Chemistry Techniques economics, Crystallography, X-Ray, Models, Molecular, Oxazoles chemical synthesis, Spectrum Analysis, Combinatorial Chemistry Techniques methods, Oxazoles chemistry
- Abstract
A class of modular oxazolines and their derivatives 1-5 were synthesized with moderate to excellent yields using a simple one-pot method; 4 x 3 bis-oxazolines were obtained, as expected, from each of the three reactions of 1,4-dicyanobenzene, 1,3-dicyanobenzene, and 1,2-dicyanobenzene with optically active amino alcohols in chlorobenzene under dry, anaerobic conditions. ZnCl(2) was used as a Lewis acid catalyst. Direct condensation of 1, 2-bis(cyanomethyl) benzene or 2-cyanophenylacetonitrile did not yield the target products, but two series of novel compounds (4 and 5) were isolated and their structures were confirmed by X-Ray analysis. All products (1-5) were characterized by NMR, IR, and MS.
- Published
- 2009
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