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Background: Salivary duct carcinoma (SDC) is a highly aggressive salivary gland malignancy with poor prognosis. The aim was to investigate the prognostic factors and survival outcomes in a cohort of SDC patients. Materials and methods: This study retrospectively analyzed the clinicopathological data of 61 SDC patients treated at the First Medical Center of the PLA General Hospital between January 2010 and December 2020. Univariate and multivariate Cox proportional hazards models were used to identify prognostic factors for overall survival (OS). Fine-Gray subdistribution hazard model was used to analyze prognostic factors for cancer-specific mortality. Results: Of the 61 patients, the parotid gland was the most common primary site (70.5%). Lymph node and distant metastases were present in 35 (57.4%) and 23 (37.7%) patients, respectively. The 5-year and 3-year OS rates were 35.2% and59.7%. Multivariate analysis identified platelet count (HR 0.99, 95%CI 0.98–1.00, P = 0.011) and distant metastasis (HR 2.79, 95%CI 1.38–5.64, P = 0.004) as independent prognostic factors for OS. Lymph node metastasis (SHR = 2.18, 95%CI 1.05–4.52, P = 0.036), distant metastasis (SHR = 3.07, 95%CI 1.47–6.42, P = 0.003), and platelet count (SHR = 0.99, 95%CI 0.99–1.00, P = 0.041) were independent prognostic factors for cancer-specific mortality. Conclusions: Distant metastasis and thrombocytopenia are important predictors of poor overall survival in SDC patients. These findings underscore the potential significance of incorporating hematological parameters and metastatic status into clinical decision-making to optimize risk stratification and personalized treatment strategies. [ABSTRACT FROM AUTHOR]

Objectives: We assessed the potential prognostic significance of the preoperative systemic inflammation index, platelet‐to‐lymphocyte ratio, and neutrophil‐to‐lymphocyte ratio in patients who underwent surgical resection. Subjects and Methods: This retrospective study included 224 patients with clinicopathologically confirmed squamous carcinoma of the tongue who underwent surgery between August 2009 and December 2017. The optimal cut‐off values for the indices were determined by receiver operating characteristic curves. Correlations between the indices and clinicopathological variables were determined by Pearson chi‐square or Fisher exact tests. The Kaplan–Meier test was used to compare overall survival between groups (high and low values); the log‐rank or Breslow test was used to assess differences in survival. Univariate and multivariate Cox regression models were used to analyze predictive values of the indices as independent indicators of overall survival. Bilateral p values of <0.05 were considered statistically significant. Results: Significant association was found between the indices and sex, tissue grade, tumor location, and lymph nodes metastases (p < 0.05). On Kaplan–Meier analysis, patients with lower values of the indices had longer overall survival (p < 0.05). Univariate and multivariate Cox regression models identified age, lymph node metastases, and neutrophil‐to‐lymphocyte ratio as independent predictors of overall survival. Conclusion: The studied indices have potential prognostic significance in patients with squamous tongue cancer. [ABSTRACT FROM AUTHOR]