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1. A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice.

Author

Fujii S, Takahashi N, Inoue H, Katsumata S, Kikkawa Y, Machida M, Ishimi Y, and Uehara M

Subjects
Absorptiometry, Photon, Animals, Bone Density drug effects, Female, Femur drug effects, Femur metabolism, Femur pathology, Food, Formulated, Fractures, Bone metabolism, Fractures, Bone pathology, Genistein urine, Isoflavones urine, Mice, Glycine max chemistry, Cellobiose administration & dosage, Equol urine, Fractures, Bone prevention & control, Isoflavones administration & dosage, Ovariectomy
Abstract

We examined the cooperative effects of isoflavones and cello-oligosaccharides on daidzein metabolism and bone fragility in ovariectomized mice. Cello-oligosaccharides increased urinary equol and decreased O-desmethylangolensin. A combination of isoflavones and cello-oligosaccharides attenuated decreases in bone breaking force and stiffness caused by ovariectomy. Combination treatment with isofalvones and cello-oligosaccharides increases urinary equol/O-desmethylangolensin production ratio and prevents ovariectomy-induced abnormalities in bone strength.

Published
2016
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