5 results on '"Meisel, Susanne F."'
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2. Anticipated health behaviour changes and perceived control in response to disclosure of genetic risk of breast and ovarian cancer: a quantitative survey study among women in the UK
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Meisel, Susanne F, Fraser, Lindsay Sarah Macduff, Side, Lucy, Gessler, Sue, Hann, Katie E J, Wardle, Jane, and Lanceley, Anne
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Adult ,Adolescent ,Health Behavior ,Breast Neoplasms ,Disclosure ,Young Adult ,breast cancer ,Risk Factors ,Surveys and Questionnaires ,Humans ,Genetic Testing ,predictive genetic testing ,Life Style ,risk ,Aged ,Ovarian Neoplasms ,Research ,Genetics and Genomics ,Middle Aged ,United Kingdom ,ovarian cancer ,Cross-Sectional Studies ,Logistic Models ,Multivariate Analysis ,Female - Abstract
Background Genetic risk assessment for breast cancer and ovarian cancer (BCOC) is expected to make major inroads into mainstream clinical practice. It is important to evaluate the potential impact on women ahead of its implementation in order to maximise health benefits, as predictive genetic testing without adequate support could lead to adverse psychological and behavioural responses to risk disclosure. Objective To examine anticipated health behaviour changes and perceived control to disclosure of genetic risk for BCOC and establish demographic and person-specific correlates of adverse anticipated responses in a population-based sample of women. Design Cross-sectional quantitative survey study carried out by the UK Office for National Statistics in January and March 2014. Setting Face-to-face computer-assisted interviews conducted by trained researchers in participants’ homes. Participants 837 women randomly chosen from households across the UK identified from the Royal Mail’s Postcode Address File. Outcome measures Anticipated health behaviour change and perceived control to disclosure of BCOC risk. Results In response to a genetic test result, most women (72%) indicated ‘I would try harder to have a healthy lifestyle’, and over half (55%) felt ‘it would give me more control over my life’. These associations were independent of demographic factors or perceived risk of BCOC in Bonferroni-corrected multivariate analyses. However, a minority of women (14%) felt ‘it isn’t worth making lifestyle changes’ and that ‘I would feel less free to make choices in my life’ (16%) in response to BCOC risk disclosure. The former belief was more likely to be held by women who were educated below university degree level (P
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- 2017
3. Population-based genetic risk prediction and stratification for ovarian cancer: views from women at high risk
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Rahman, Belinda, Meisel, Susanne F., Fraser, Lindsay, Side, Lucy, Gessler, Sue, Wardle, Jane, and Lanceley, Anne
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Adult ,Ovarian Neoplasms ,Cancer Research ,Health Knowledge, Attitudes, Practice ,Genetic testing ,High risk ,Middle Aged ,Risk prediction ,Interviews as Topic ,Oncology ,Ovarian cancer ,BRCA1/2 ,Risk Factors ,Genetics ,Humans ,Genetics(clinical) ,Original Article ,Female ,Genetic Predisposition to Disease ,Risk stratification ,Qualitative Research - Abstract
There is an opportunity to improve outcomes for ovarian cancer (OC) through advances in risk stratification, early detection and diagnosis. A population-based OC genetic risk prediction and stratification program is being developed. A previous focus group study with individuals from the general population showed support for the proposed program. This qualitative interview study explores the attitudes of women at high risk of OC. Eight women participated in one-on-one, in-depth, semi-structured interviews to explore: experiences of learning of OC risk, risk perceptions, OC knowledge and awareness, and opinions on risk stratification approach. There was evidence of strong support for the proposed program. Benefits were seen as providing reassurance to women at low risk, and reducing worry in women at high risk through appropriate clinical management. Stratification into 'low' and 'high' risk groups was well-received. Participants were more hesitant about stratification to the 'intermediate' risk group. The data suggest formats to effectively communicate OC risk estimates will require careful thought. Interactions with GPs were highlighted as a barrier to OC risk assessment and diagnosis. These results are encouraging for the possible introduction and uptake of a risk prediction and stratification program for OC in the general population.
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- 2014
4. Impact of a decision aid about stratified ovarian cancer risk-management on women's knowledge and intentions: a randomised online experimental survey study.
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Meisel, Susanne F., Freeman, Maddie, Waller, Jo, Fraser, Lindsay, Gessler, Sue, Jacobs, Ian, Kalsi, Jatinderpal, Manchanda, Ranjit, Rahman, Belinda, Side, Lucy, Wardle, Jane, Lanceley, Anne, Sanderson, Saskia C., and PROMISE team
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OVARIAN cancer , *HEALTH surveys , *CANCER risk factors , *DISEASES in women , *DECISION making , *EARLY detection of cancer , *COMPARATIVE studies , *DISEASE susceptibility , *HEALTH attitudes , *INTENTION , *INTERNET , *RESEARCH methodology , *MEDICAL cooperation , *OVARIAN tumors , *RESEARCH , *RESEARCH funding , *EVALUATION research , *RANDOMIZED controlled trials , *PREVENTION , *PSYCHOLOGY - Abstract
Background: Risk stratification using genetic and other types of personal information could improve current best available approaches to ovarian cancer risk reduction, improving identification of women at increased risk of ovarian cancer and reducing unnecessary interventions for women at lower risk. Amounts of information given to women may influence key informed decision-related outcomes, e.g. knowledge. The primary aim of this study was to compare informed decision-related outcomes between women given one of two versions (gist vs. extended) of a decision aid about stratified ovarian cancer risk-management.Methods: This was an experimental survey study comparing the effects of brief (gist) information with lengthier, more detailed (extended) information on cognitions relevant to informed decision-making about participating in risk-stratified ovarian cancer screening. Women with no personal history of ovarian cancer were recruited through an online survey company and randomised to view the gist (n = 512) or extended (n = 519) version of a website-based decision aid and completed an online survey. Primary outcomes were knowledge and intentions. Secondary outcomes included attitudes (values) and decisional conflict.Results: There were no significant differences between the gist and extended conditions in knowledge about ovarian cancer (time*group interaction: F = 0.20, p = 0.66) or intention to participate in ovarian cancer screening based on genetic risk assessment (t(1029) = 0.43, p = 0.67). There were also no between-groups differences in secondary outcomes. In the sample overall (n = 1031), knowledge about ovarian cancer increased from before to after exposure to the decision aid (from 5.71 to 6.77 out of a possible 10: t = 19.04, p < 0.001), and 74% of participants said that they would participate in ovarian cancer screening based on genetic risk assessment.Conclusions: No differences in knowledge or intentions were found between women who viewed the gist version and women who viewed the extended version of a decision aid about risk-stratified ovarian cancer screening. Knowledge increased for women in both decision aid groups. Further research is needed to determine the ideal volume and type of content for decision aids about stratified ovarian cancer risk-management.Trial Registrations: This study was registered with the ISRCTN registry; registration number: ISRCTN48627877 . [ABSTRACT FROM AUTHOR]- Published
- 2017
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5. Genetic testing and personalized ovarian cancer screening: a survey of public attitudes.
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Meisel, Susanne F., Rahman, Belinda, Side, Lucy, Fraser, Lindsay, Gessler, Sue, Lanceley, Anne, Wardle, Jane, and PROMISE-2016 study team
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OVARIAN cancer , *REGRESSION analysis , *WOMEN'S health , *GENETIC testing , *MEDICAL care , *OVARIAN tumors , *ATTITUDE (Psychology) , *NATIONAL health services , *PUBLIC opinion , *RESEARCH funding , *RISK assessment , *EARLY detection of cancer , *STANDARDS , *DIAGNOSIS - Abstract
Background: Advances in genetic technologies are expected to make population-wide genetic testing feasible. This could provide a basis for risk stratified cancer screening; but acceptability in the target populations has not been explored.Methods: We assessed attitudes to risk-stratified ovarian cancer (OC) screening based on prior genetic risk assessment using a survey design. Home-based interviews were carried out by the UK Office of National Statistics in a population-based sample of 1095 women aged 18-74. Demographic and personal correlates of attitudes to risk-stratified OC screening based on prior genetic risk assessment were determined using univariate analyses and adjusted logistic regression models.Results: Full data on the key analytic questions were available for 829 respondents (mean age 46 years; 27 % 'university educated'; 93 % 'White'). Relatively few respondents felt they were at 'higher' or 'much higher' risk of OC than other women of their age group (7.4 %, n = 61). Most women (85 %) said they would 'probably' or 'definitely' take up OC genetic testing; which increased to 88 % if the test also informed about breast cancer risk. Almost all women (92 %) thought they would 'probably' or 'definitely' participate in risk-stratified OC screening. In multivariate logistic regression models, university level education was associated with lower anticipated uptake of genetic testing (p = 0.009), but with more positive attitudes toward risk-stratified screening (p <0.001). Perceived risk was not significantly associated with any of the outcome variables.Conclusions: These findings give confidence in taking forward research on integration of novel genomic technologies into mainstream healthcare. [ABSTRACT FROM AUTHOR]- Published
- 2016
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