8 results on '"Quarato, Pier Paolo"'
Search Results
2. Surgery after intracranial investigation with subdural electrodes in patients with drug-resistant focal epilepsy: outcome and complications
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Morace, Roberta, Di Gennaro, Giancarlo, Picardi, Angelo, Quarato, Pier Paolo, Sparano, Antonio, Mascia, Addolorata, Meldolesi, Giulio Nicolò, Grammaldo, Liliana Graciela, De Risi, Marco, and Esposito, Vincenzo
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- 2012
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3. Temporal pole abnormalities detected by 3 T MRI in temporal lobe epilepsy due to hippocampal sclerosis: No influence on seizure outcome after surgery.
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Casciato, Sara, Picardi, Angelo, D’Aniello, Alfredo, De Risi, Marco, Grillea, Giovanni, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Meldolesi, Giulio Nicolo’, Morace, Roberta, Esposito, Vincenzo, Di Gennaro, Giancarlo, D'Aniello, Alfredo, and Meldolesi, Giulio Nicolo'
- Abstract
Purpose: To assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) detected by using 3 Tesla MRI in the preoperative workup in patients with temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS) who underwent surgery.Methods: We studied 78 consecutive patients with TLE-HS who underwent surgery and were followed up for at least 2 years. Based on findings of pre-surgical 3 Tesla MRI, patients were subdivided in subgroups according to the presence of TB or TA. Subgroups were compared on demographic, clinical, neuropsychological data and seizure outcome.Results: TB was found in 39 (50%) patients, while TA was found in 32 (41%) patients, always ipsilateral to HS, with a considerable degree of overlap (69%) between TB and TA (p=0.01). Patients with temporopolar abnormalities did not significantly differ from those without TB or TA with regard to sex, age, age of epilepsy onset, duration of epilepsy, history of febrile convulsions or birth complications, side of surgery, seizure frequency at surgery, presence of GTCSs, and, in particular, seizure outcome. On the other hand, TB patients show a less frequent family history of epilepsy (p<.05) while age at epilepsy onset showed a trend to be lower in the TB group (p=.09). Patients with temporopolar atrophy did not significantly differ from those without TA on any variable, except for age at epilepsy onset, which was significantly lower for the TA group (p<.05). History of birth complications and longer duration of epilepsy also showed a trend to be associated with TA (p=.08). Multivariate analysis corroborated the association between temporopolar abnormalities and absence of family history of epilepsy and history of birth complications.Conclusions: High-field 3 T MRI in the preoperative workup for epilepsy surgery confirms that temporopolar abnormalities are frequent findings in TLE-HS patients and may be helpful to lateralize the epileptogenic zone. Their presence did not influence seizure outcome. [ABSTRACT FROM AUTHOR]- Published
- 2017
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4. Temporal pole abnormalities in temporal lobe epilepsy with hippocampal sclerosis: Clinical significance and seizure outcome after surgery.
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Di Gennaro, Giancarlo, D’Aniello, Alfredo, De Risi, Marco, Grillea, Giovanni, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Casciato, Sara, Morace, Roberta, Esposito, Vincenzo, Picardi, Angelo, and D'Aniello, Alfredo
- Abstract
Purpose: To assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) with a long post-surgical follow-up.Methods: We studied 60 consecutive patients with TLE-HS and 1.5 preoperative MRI scans who underwent surgery and were followed up for at least 5 years (mean follow-up 7.3 years). Based on findings of pre-surgical MRI, patients were classified according to the presence of TB or TA. Groups were compared on demographic, clinical, neuropsychological data, and seizure outcome.Results: TB was found in 37 (62%) patients, while TA was found in 35 (58%) patients, always ipsilateral to HS, with a high degree of overlap (83%) between TB and TA (p<0.001). Patients with TB did not differ from those without TB with regard to history of febrile convulsions, GTCSs, age of epilepsy onset, side of surgery, seizure frequency, seizure outcome, and neuropsychological outcome. On the other hand, they were significantly older, had a longer duration of epilepsy, and displayed lower preoperative scores on several neuropsychological tests. Similar findings were observed for TA. Multivariate analysis corroborated the association between temporopolar abnormalities and age at onset, age at surgery (for TB only), and lower preoperative scores on some neuropsychological tests.Conclusions: Temporopolar abnormalities are frequent in patients with TLE-HS. Our data support the hypothesis that TB and TA are caused by seizure-related damages. These abnormalities did not influence seizure outcome, even after a long-term post-surgical follow-up. [ABSTRACT FROM AUTHOR]- Published
- 2015
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5. Postoperative EEG and seizure outcome in temporal lobe epilepsy surgery
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Di Gennaro, Giancarlo, Quarato, Pier Paolo, Sebastiano, Fabio, Esposito, Vincenzo, Onorati, Paolo, Mascia, Addolorata, Romanelli, Pantaleo, Grammaldo, Liliana G., Falco, Carolina, Scoppetta, Ciriaco, Eusebi, Fabrizio, Manfredi, Mario, and Cantore, Giampaolo
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ELECTROENCEPHALOGRAPHY , *TEMPORAL lobe , *EPILEPSY , *OPERATIVE surgery - Abstract
Objective: To assess the prognostic value of scalp electroencephalogram (EEG) after epilepsy surgery, we investigated whether postoperative EEG abnormalities (interictal epileptiform discharges, IED; interictal slow activity, ISA) were associated with seizure outcome and other patient characteristics after resective surgery in patients with temporal lobe epilepsy (TLE).Methods: Sixty-two patients with medically refractory TLE who underwent surgery were studied. Patients were categorized according to etiology (mesiotemporal sclerosis vs. tumors/cortical dysplasias); extent of surgical resection (extensive vs. limited); and amount of preoperative IED on wake EEG (oligospikers, <1 IED/h, vs. spikers). Patients were also classified as seizure-free (SF) or having persistent seizures/auras (not-SF) during follow up visits 1 month and 1 year after surgery. Preoperative 60-min interictal EEGs were evaluated for IED and ISA, and compared to postoperative wake EEGs.Results: Seizures/auras persisted in 16/62 (25.8%) patients at 1 month and in 8/62 (12.9%) at 1 year follow up. ISA was not significantly related to outcome. Of 42 patients with EEG negative for IED at 1 month, 4 were not-SF; at 1 year, one of 44 such patients was not-SF. IED was significantly associated with seizure/aura persistence in patients categorized as mesiotemporal sclerosis and with extensive surgery. Oligospikers and spikers on preoperative EEG showed no differences in the postoperative seizure outcome, excellent in both cases; moreover, the presence of postoperative IEDs indicated auras/seizures persistence apart from the preoperative EEG spike frequency.Conclusions: Our study showed that the presence of IED of postoperatve EEG strongly indicates seizure/aura persistence. Therefore, serial EEGs should be included in postoperative follow up schedules as a crucial tool in evaluating seizure outcome. [Copyright &y& Elsevier]
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- 2004
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6. Prognostic significance of serial postoperative EEG in extratemporal lobe epilepsy surgery
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Di Gennaro, Giancarlo, De Risi, Marco, Quarato, Pier Paolo, Sparano, Antonio, Mascia, Addolorata, Grammaldo, Liliana G., Meldolesi, Giulio N., Esposito, Vincenzo, and Picardi, Angelo
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TEMPORAL lobe epilepsy , *ELECTROENCEPHALOGRAPHY , *EPILEPSY surgery , *WAKEFULNESS , *SEIZURES (Medicine) , *ANTICONVULSANTS , *HEALTH outcome assessment , *FOLLOW-up studies (Medicine) , *UNIVARIATE analysis - Abstract
Abstract: Objective: To assess the prognostic value of postoperative EEG in patients surgically treated for drug-resistant extra-temporal lobe (ET) epilepsy. Methods: We studied 63 consecutive patients with ET epilepsy who underwent epilepsy surgery and were followed up for at least 2years (mean duration of follow-up 6.2±2.3years, range 2–12). Follow-up evaluations were performed 2, 12, and 24months after surgery, and included standard EEG (at 2months) and long-term video-EEG monitoring during both wakefulness and sleep (at 12 and 24months). Seizure outcome was determined at each follow-up evaluation, and then at yearly intervals. Patients who were in Engel Class I at the last contact were classified as having a good outcome. Results: Seizure outcome was good in 39 patients (62%). The presence of interictal epileptiform discharges (IED) in postoperative EEG at each time point was found to be associated with poor outcome. The strength of this association was greater for awake plus sleep recording as compared with awake recording alone. In a multiple regression model including all pre- and post-operative factors identified as predictors of outcome in univariate analysis, the presence of early (2months after surgery) EEG epileptiform abnormalities was found to be independently associated with poor seizure outcome. Conclusions: Postoperative IED may predict long-term outcome in patients undergoing resective surgery for ET epilepsy. Significance: The increase in risk of unfavourable outcome associated with EEG epileptiform abnormalities detected as early as two months after surgery may have substantial practical importance. Serial postoperative EEGs including sleep recording may add further predictive power and help making decision about antiepileptic drug discontinuation. [Copyright &y& Elsevier]
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- 2012
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7. Serial postoperative awake and sleep EEG and long-term seizure outcome after anterior temporal lobectomy for hippocampal sclerosis.
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Di Gennaro, Giancarlo, Casciato, Sara, D’Aniello, Alfredo, De Risi, Marco, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Meldolesi, Giulio N., Esposito, Vincenzo, and Picardi, Angelo
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POSTOPERATIVE care , *ELECTROENCEPHALOGRAPHY , *SPASM treatment , *DISEASE relapse , *EPILEPSY risk factors - Abstract
Highlights: [•] IED in serial EEG may predict long-term seizure outcome after ATL for TLE-HS. [•] Presence of IED in serial postoperative EEG was associated with recurrence of seizures/auras. [•] Sleep EEG recording may contribute to detect patients at higher risk of recurrence. [ABSTRACT FROM AUTHOR]
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- 2014
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8. Prognostic significance of acute postoperative seizures in extra-temporal lobe epilepsy surgery.
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Di Gennaro, Giancarlo, D’Aniello, Alfredo, De Risi, Marco, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Meldolesi, Giulio N., Esposito, Vincenzo, Fabi, Elisa, and Picardi, Angelo
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SPASMS , *TEMPORAL lobe epilepsy , *SURGICAL complications , *DRUG resistance , *TEMPORAL lobe surgery , *HEALTH outcome assessment , *PROGNOSIS - Abstract
Highlights: [•] We evaluated the prognostic value of acute postoperative seizures (APOS) after surgery for drug-resistant extra-temporal lobe epilepsy. [•] APOS are relatively common in these patients. [•] The occurrence of APOS may independently predict long-term seizure outcome. [ABSTRACT FROM AUTHOR]
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- 2013
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