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Your search keyword '"Thijs O. Verhagen"' showing total 2 results
Start Over Author "Thijs O. Verhagen" Topic otorhinolaryngology
2 results on '"Thijs O. Verhagen"'

1. An exceptional cause of unilateral sensorineural hearing loss: Progressive multifocal leukoencephalopathy

Author

Thijs O. Verhagen, Eline Rappel, Emile F. Schippers, and Jan Pieter Koopman

Subjects
Sensorineural hearing loss, Audiometry, Immunology, Otorhinolaryngology, RF1-547
Abstract

We describe progressive multifocal leukoencephalopathy (PML) as an extremely rare cause of unilateral sensorineural hearing loss. A 46-year-old HIV-infected and immunocompromised patient suffered from hearing loss in the left ear since several days. Because of the discrepancy between the normal tone audiogram and the abnormal speech audiogram, MRI was indicated. The scan showed a hyperintense lesion at the left side of the cerebellum, extending to the cranial portion of the medulla oblongata. The lesion was initially diagnosed as PML. Since the symptoms progressed despite earlier initiated and effective treatment with combination antiretroviral therapy, the disease was eventually interpreted as PML-immune reconstruction inflammatory syndrome (PML-IRIS). This case demonstrates that the diagnosis of PML or PML-IRIS should be considered as cause of hearing loss in immunocompromised patients. Also, the importance of complete audiological evaluation including speech audiometry in analysis of subjective hearing impairment is illustrated.

Published
2023
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2. Bilateral medialization thyroplasty in patients with vocal fold atrophy with or without sulcus

Author

Thijs O Verhagen, Vivienne A H van de Kamp-Lam, Elisabeth V. Sjögren, Emke M J M van den Broek, Bas J. Heijnen, Martine Hendriksma, Peter Paul G. van Benthem, and Antonius P. M. Langeveld

Subjects
Male, medicine.medical_specialty, Glottic insufficiency, Vocal Cords, Laryngology, 03 medical and health sciences, Laryngoplasty, 0302 clinical medicine, Atrophy, Medicine, Humans, Prospective Studies, Voice Handicap Index, 030223 otorhinolaryngology, Prospective cohort study, Retrospective Studies, business.industry, Bilateral medialization thyroplasty, Type 1 thyroplasty, Vocal fold atrophy, Retrospective cohort study, General Medicine, Sulcus, medicine.disease, Surgery, medicine.anatomical_structure, Treatment Outcome, Otorhinolaryngology, 030220 oncology & carcinogenesis, Laryngeal framework surgery, Neurosurgery, business
Abstract

Purpose To evaluate voice outcome after bilateral medialization thyroplasty in patients with non-paralytic glottic insufficiency due to vocal fold atrophy with or without sulcus. Methods Retrospective cohort study on 29 patients undergoing bilateral medialization thyroplasty for vocal fold atrophy (14 procedures) or atrophy with sulcus (15 procedures) between October 2012 and November 2017. Voice data were collected and analyzed for the preoperative and the 3- and 12-month postoperative time point according to a standardized protocol, including Voice Handicap Index (VHI)-30 and perceptual, acoustic and aerodynamic parameters. Failure rate was based on number of revisions within 12 months and non-relevant improvement ( Results There was a clinically relevant (≥ 15 points) and statistically significant improvement (p p = 0.0001). The pre- and post-operative grade of dysphonia was significantly lower in patients with atrophy compared to atrophy and sulcus (mean difference 0.70, p = 0.017). Conclusion Bilateral medialization thyroplasty is a valid treatment option for patients with atrophy with or without sulcus. Outcomes are comparable to other methods reported in literature. However, there is a great need for larger, prospective studies with long-term follow-up to gain more insight into the comparative voice outcomes for the different forms of surgery for patients with glottic incompetence due to atrophy with or without sulcus.

Published
2020

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