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3 results on '"Saltigeral-Simental P"'

1. Presentation and Outcomes of Kawasaki Disease in Latin American Infants Younger Than 6 Months of Age: A Multinational Multicenter Study of the REKAMLATINA Network

Author

Moreno, Elizabeth, Garcia, S Diana, Bainto, Emelia, Salgado, Andrea P, Parish, Austin, Rosellini, Benjamin D, Ulloa-Gutierrez, Rolando, Garrido-Garcia, Luis M, Dueñas, Lourdes, Estripeaut, Dora, Luciani, Kathia, Rodríguez-Quiroz, Francisco J, del Aguila, Olguita, Camacho-Moreno, Germán, Gómez, Virgen, Viviani, Tamara, Alvarez-Olmos, Martha I, de Souza Marques, Heloisa Helena, Faugier-Fuentes, Enrique, Saltigeral-Simental, Patricia, López-Medina, Eduardo, Miño-León, Greta, Beltrán, Sandra, Martínez-Medina, Lucila, Pirez, Maria C, Cofré, Fernanda, and Tremoulet, Adriana H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Brain Disorders, Clinical Trials and Supportive Activities, Clinical Research, Kawasaki disease, Latin America, infants, coronary artery abnormalities, delayed diagnosis, The REKAMLATINA-2 Study Group Investigators, Paediatrics and Reproductive Medicine, Other Medical and Health Sciences, Paediatrics
Abstract

Objective: To characterize the clinical presentation and outcomes of Kawasaki disease (KD) in infants 10 days (50 vs. 7.4%, P = 0.043)]. Conclusion: Our data show that despite treatment in the first 10 days of illness, infants

Published
2020

2. Presentation and Outcomes of Kawasaki Disease in Latin American Infants Younger Than 6 Months of Age: A Multinational Multicenter Study of the REKAMLATINA Network.

Author

Moreno, Elizabeth, Garcia, S Diana, Bainto, Emelia, Salgado, Andrea P, Parish, Austin, Rosellini, Benjamin D, Ulloa-Gutierrez, Rolando, Garrido-Garcia, Luis M, Dueñas, Lourdes, Estripeaut, Dora, Luciani, Kathia, Rodríguez-Quiroz, Francisco J, Del Aguila, Olguita, Camacho-Moreno, Germán, Gómez, Virgen, Viviani, Tamara, Alvarez-Olmos, Martha I, de Souza Marques, Heloisa Helena, Faugier-Fuentes, Enrique, Saltigeral-Simental, Patricia, López-Medina, Eduardo, Miño-León, Greta, Beltrán, Sandra, Martínez-Medina, Lucila, Pirez, Maria C, Cofré, Fernanda, Tremoulet, Adriana H, and The REKAMLATINA-2 Study Group Investigators

Subjects
The REKAMLATINA-2 Study Group Investigators, Kawasaki disease, Latin America, coronary artery abnormalities, delayed diagnosis, infants, Paediatrics and Reproductive Medicine, Other Medical and Health Sciences
Abstract

Objective: To characterize the clinical presentation and outcomes of Kawasaki disease (KD) in infants 10 days (50 vs. 7.4%, P = 0.043)]. Conclusion: Our data show that despite treatment in the first 10 days of illness, infants

Published
2020

3. Use of Adjunctive Therapy in Acute Kawasaki Disease in Latin America

Author

Fortuna-Reyna, Brenda, Bainto, Emelia V, Ulloa-Gutierrez, Rolando, Garrido-García, Luis M, Estripeaut, Dora, del Águila, Olguita, Gómez, Virgen, Faugier-Fuentes, Enrique, Miño-León, Greta, Beltrán, Sandra, Cofré, Fernanda, Chacón-Cruz, Enrique, Saltigeral-Simental, Patricia, Martínez-Medina, Lucila, Dueñas, Lourdes, Luciani, Kathia, Rodríguez-Quiroz, Francisco J, Camacho-Moreno, German, Viviani, Tamara, Alvarez-Olmos, Martha I, de Sousa Marques, Heloisa Helena, López-Medina, Eduardo, Pirez, María C, Tremoulet, Adriana H, and Group, The Kawasaki Disease REKAMLATINA Network Study

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Kawasaki disease, Latin America, steroids, infliximab, adjunctive therapy, Kawasaki Disease REKAMLATINA Network Study Group, Paediatrics and Reproductive Medicine, Other Medical and Health Sciences, Paediatrics
Abstract

Objective: To characterize the use of adjunctive therapy in Kawasaki disease (KD) in Latin America. Methods: The study included 1,418 patients from the Latin American KD Network (REKAMLATINA) treated for KD between January 1, 2009, and May 31, 2017. Results: Of these patients, 1,152 received only a single dose of IVIG, and 266 received additional treatment. Age at onset was similar in both groups (median 2 vs. 2.2 years, respectively). The majority of patients were male (58 vs. 63.9%) and were hospitalized with the first 10 days of fever (85.1 vs. 84.2%). The most common adjunctive therapy administered was steroids for IVIG-resistance, followed by additional doses of IVIG. The use of biologics such as infliximab was limited. KD patients who received adjunctive therapy were more likely to have a lower platelet count and albumin level as well as a higher Z score of the coronary arteries. Conclusion: This is the first report of adjunctive therapies for KD across Latin America. IVIG continues to be the initial and resistance treatment, however, steroids are also used and to a lesser extent, biological therapy such as infliximab. Future studies should address the barriers to therapy in children with acute KD throughout Latin America.

Published
2020

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