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Backgroud: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients., Method: A cross-sectional study recruits 1398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression., Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P < 0.001) and SLE (39.6%, P = 0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P < 0.001), OA (P = 0.02) and SLE (P = 0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of 'score below the expected range for age', osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors., Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.

Objective To investigate the potential risk factors of the incidence of osteoporosis in patients with systemic lupus erythematosus （SLE）. Methods In this study, 125 sex- and age-matched SLE patients （SLE group） and 125 healthy controls （HC group） were screened from the Third Affiliated Hospital of Sun Yat-sen University,Fujian Provincial General Hospital, Ganzhou Municipal Hospital and the Second Affiliated Hospital of Shantou University Medical College using the PSM matching method. Clinical data were collected. Bone mineral density （BMD） of the lumbar spine, femoral neck and total hip was measured. T values in male and postmenopausal female aged≥50 years were calculated and Z values in male and premenopausal female aged < 50 years were calculated. The risk factors of the incidence of osteoporosis in SLE patients between two groups were identified by logistic regression analysis. Results The lumbar spine BMD （T value） in patients with SLE was lower than that in the HC group （P < 0.05）. The lumbar spine, femoral neck and total hip BMD （Z value） in the SLE group were lower than those in the HC group （all P < 0.05）. Besides, the probability of abnormal BMD regarding the T and Z values in the SLE group was higher compared with that in the HC group （both P < 0.05）. In the SLE group, the proportion of normal BMD according to the T value was lower than that in the HC group, especially the lumbar spine. In the SLE group, the proportion of lumbar spine, femoral neck and total hip BMD （Z value） lower than normal level was higher than that in the HC group. In the SLE group, long disease duration, history of glucocorticoid use, age > 50 years and coronary artery disease were the risk factors of osteoporosis in SLE patients. Conclusions SLE patients with long disease duration, history of glucocorticoid use, age > 50 years and coronary artery disease are high-risk population for osteoporosis.