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7 results on '"Arrabal Polo, Miguel Ángel"'

1. The value of hypercalciuria in patients with osteopenia versus osteoporosis.

Author

Girón-Prieto MS, Del Carmen Cano-García M, Poyatos-Andújar A, Arias-Santiago S, de Haro-Muñoz T, Arrabal-Martín M, and Arrabal-Polo MÁ

Subjects
Adult, Aged, Bone Diseases, Metabolic blood, Bone Diseases, Metabolic therapy, Bone and Bones metabolism, Creatinine blood, Creatinine urine, Cross-Sectional Studies, Densitometry, Female, Humans, Hypercalciuria blood, Male, Middle Aged, Osteocalcin blood, Osteocalcin urine, Osteoporosis blood, Osteoporosis therapy, Bone Diseases, Metabolic urine, Calcium urine, Hypercalciuria urine, Osteoporosis urine
Abstract

The aim of this study was to analyze the presence of lithogenic metabolic factors in the blood and urine of patients with osteopenia versus osteoporosis. This is a cross-sectional study including 67 patients who were divided into two groups according to the presence of either osteopenia or osteoporosis as measured by bone densitometry: group 1-40 patients with osteopenia (22 men and 18 women) and group 2-27 patients with osteoporosis (13 men and 14 women). Metabolic studies were performed on the blood and urine; statistical analysis was performed comparing means and conducting linear correlation and multivariate analyses with SPSS. Statistical significance was considered to be p ≤ 0.05. The mean age of patients in group 1 was 52.9 ± 12.8 years versus 50.3 ± 11.4 in group 2; the difference was not statistically significant. In group 2, higher levels of osteocalcin, β-crosslaps, urinary calcium, fasting urine calcium/creatinine, 24 h urine calcium/creatinine and 24 h oxaluria were observed compared to group 1. In the multivariate analysis, only the β-crosslaps and urinary calcium were independently associated with osteoporosis. It would be advisable to determine the urinary calcium levels in patients with osteoporosis since altered levels may necessitate modifying the diagnostic and therapeutic approach to osteoporosis.

Published
2017
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2. Bone remodeling markers as lithogenic risk factors in patients with osteopenia-osteoporosis.

Author

Girón-Prieto MS, Arias-Santiago S, Del Carmen Cano-García M, Poyatos-Andújar A, de Haro-Muñoz T, Abad-Menor F, Quesada-Charneco M, Arrabal-Polo MÁ, and Arrabal-Martín M

Subjects
Absorptiometry, Photon, Adult, Alkaline Phosphatase blood, Biomarkers blood, Biomarkers urine, Bone Density, Calcium blood, Calcium urine, Case-Control Studies, Citric Acid urine, Collagen urine, Cross-Sectional Studies, Fasting, Female, Humans, Male, Middle Aged, Nephrolithiasis blood, Nephrolithiasis urine, Osteocalcin urine, Osteoporosis diagnostic imaging, Oxalic Acid urine, Parathyroid Hormone blood, Peptide Fragments urine, Risk Factors, Uric Acid urine, Bone Remodeling, Osteoporosis blood, Osteoporosis urine
Abstract

Purpose: To analyze the presence of phosphocalcic metabolism disorders in patients with osteopenia-osteoporosis without nephrolithiasis with respect to a control group., Methods: A cross-sectional study was conducted in patients with osteopenia-osteoporosis without nephrolithiasis (n = 67) in lumbar spine or femur and in a control group (n = 61) with no lithiasis or bone disorders. Blood bone markers, phosphocalcic metabolism, fasting urine, 24-h urine lithogenic risk factors, and densitometry were recorded in both groups. SPSS 20.0 was used for statistical analysis., Results: In comparison with the controls, significantly higher blood calcium (9.27 ± 0.36 vs. 9.57 ± 0.38, p = 0.0001), intact parathormone (45.6 ± 14.9 vs. 53.8 ± 18.9, p = 0.008), and alkaline phosphatase (61.9 ± 20.9 vs. 70.74 ± 18.9, p = 0.014) levels were found in patients with osteopenia-osteoporosis. In the 24-h urine test, citrate (1010.7 ± 647.8 vs. 617.6 ± 315.8, p = 0.0001) and oxalate (28.21 ± 17.65 vs. 22.11 ± 16.49, p = 0.045) levels were significantly lower in osteopenia-osteoporosis patients than in controls, with no significant difference in calcium (187.3 ± 106.9 vs. 207.06 ± 98.12, p = 0.27) or uric acid (540.7 ± 186.2 vs. 511.9 ± 167.06, p = 0.35) levels. Patients with osteopenia-osteoporosis had significantly higher levels of lithogenic risk factors associated with bone remodeling, including significantly increased β-crosslaps and osteocalcin values and higher β-crosslaps/osteocalcin ratios., Conclusion: Patients with osteopenia-osteoporosis without nephrolithiasis showed phosphocalcic metabolism disorders as well as lower urinary citrate and higher β-crosslaps/osteocalcin and fasting calcium/creatinine ratios, which would increase the risk of nephrolithiasis. Hence, prospective studies are warranted to evaluate the long-term risks.

Published
2016
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3. Linking of psoriasis with osteopenia and osteoporosis: A cross‑sectional study

Author

Blasco Morente, Gonzalo, Martínez López, Antonio, Girón Prieto, María Sierra, Arrabal Polo, Miguel Ángel, Luque Valenzuela, María, Luna Del Castillo, Juan De Dios, Tercedor Sánchez, Jesús, and Arias Santiago, Salvador Antonio

Subjects
musculoskeletal diseases, Osteopenia, Bone mineral density, Osteoporosis, Psoriasis, Vitamin D, Body mass index
Abstract

Psoriasis is a multisystem disease which has been related to vitamin‑D deficiency through chronic inflammation. This psoriasis‑related inflammatory state and vitamin‑D deficiency may induce bone mineral density loss. The purpose of this study is to assess the relationship of psoriasis with bone mineral density, by comparing psoriatic patients with healthy controls and patients with osteopenia/osteoporosis. Psoriatic patients showed worse hip and lumbar spine bone mineral density levels than healthy controls (P = 0.001) and better levels than osteoporotic patients (P < 0.001). Multivariate analysis demonstrated a negative association of age and a positive association of body mass index in hip bone mineral density in psoriatic patients. Bone mineral density levels in psoriatic patients are situated halfway between healthy controls and patients with osteopenia/osteoporosis. In addition, the higher body mass index in patients with psoriasis appears to confer a protective effect against further development of lower bone mineral density.

Published
2019

4. Litiasis renal cálcica y pérdida de masa ósea. Aplicación de marcadores en el diagnóstico y control terapéutico

Author

Arrabal Polo, Miguel Ángel, Universidad de Granada. Departamento de Cirugía y sus especialidades, Arrabal-Martín, Miguel, Zuluaga-Gómez, Armando, and Universidad de Granada. Departamento de Cirugía y sus Especialidades

Subjects
Calcio, 3207.14, Litiasis renal, 546.41, 616.7, Diagnóstico y tratamiento, Osteoporosis, Huesos
Abstract

Tesis Univ. Granada. Departamento de Cirugía y sus especialidades. Leída el 1 de marzo de 2012

Published
2012

5. Efecto de los aminobifosfonatos y tiacidas en pacientes con osteopenia/osteoporosis y litiasis renal cálcica recidivante

Author

González-Torres, Samuel, Arrabal-Martín, Miguel, Arrabal Polo, Miguel Ángel, Universidad de Granada. Departamento de Cirugía y sus Especialidades, and Arrabal-Polo, Miguel Ángel

Subjects
Metabolismo, Tiacidas, Cálculos (Patología), Osteopenia, Bifosfonatos, Terapéutica, Enfermos, Cálculos renales, Osteoporosis, Alendronato, (043.2)
Abstract

La litiasis renal ha sido y es un problema mayor de salud, que genera importante morbilidad y afortunadamente, hoy en día, menos mortalidad que en el pasado. El 60% de los pacientes con litiasis renal cálcica presenta hipercalciuria y en el 55% de los pacientes con hipercalciuria se detecta osteopenia/osteoporosis. La relación entre osteopenia/osteoporosis y litiasis renal cálcica es reconocida en diferentes estudios. Se ha observado relación entre pérdida de densidad mineral ósea, hipercalciuria, hipocitraturia y litiasis renal, más significativa en pacientes con litiasis renal cálcica recidivante. El ánimo de esta tesis es el estudio de los parámetros metabólicos y óseos en pacientes con litiasis renal cálcica y poder evaluar en el tiempo las respuestas de estos parámetros con la introducción de bifosfonatos y tiacidas, haciendo especial énfasis durante el tratamiento en la recurrencia, parámetros de densitometría y valores séricos y urinarios de remodelado óseo. El objetivo de este trabajo, es estudiar el efecto clínico y bioquímico del Alendronato Sódico en el control de la perdida de masa ósea y factores de riesgo litogénico renal, en pacientes con osteopenia/osteoporosis y litiasis renal cálcica recidivante, frente al efecto obtenido con Hidroclorotiacida., Tesis Univ. Granada. Programa Oficial de Doctorado en: Medicina y Dermatología

Published
2016

6. Study of lithogenic factors in patients with osteoporotic fracture

Author

Ochoa-Hortal Rull, Miguel Ángel, Arrabal Polo, Miguel Ángel, Universidad de Granada. Departamento de Cirugía y sus Especialidades, and Arrabal-Polo, Miguel Ángel

Subjects
Cirugía, 616.7, Fractura osteoporótica, Osteoporosis, Fracturas, Litogénico, Fisiología patológica, 616.71
Abstract

Several studies in the literature have shown a relationship between osteopenia/osteoporosis and calcium nephrolithiasis. Apart from this clinical relationship, patients with recurrent calcium nephrolithiasis show altered markers of bone remodeling (bone formation and mainly resorption) and urinary lithogenic activity markers such as calciuria, citraturia, calcium/creatinine ratio and calcium/citrate ratio. Although the relationship and causality link between these two conditions is not well known, genetic, immunologic, inflammatory and dietetic factors could be facilitating the appearance and maintenance of the osteoporosis-renal lithiasis pairing. It seems that the presence of recurrent calcium nephrolithiasis is a risk factor in the development of bone fractures in patients with osteoporosis due to an increase of its accumulated incidence as time passes. The aim of this doctoral dissertation is to study the lithogenic factors in patients with osteoporotic fractures in order to determine if they are altered as compared to the general population., La osteoporosis es una enfermedad muy prevalente que se relaciona entre otras patologías con la litiasis renal de composición cálcica. Los pacientes con litiasis renal cálcica recidivante presentan un aumento en la pérdida de DMO O DENSIDAD MINERAL ÓSEA? que se expresa con la elevación de marcadores de remodelado óseo y con la presencia de hipercalciuria de ayunas e hipocitraturia entre otras alteraciones. Por su parte, los pacientes con osteoporosis expresan con frecuencia aumento de la excreción renal de calcio que representa un factor de riesgo litogénico. Una de las complicaciones más habituales de la osteoporosis es la aparición de fractura como consecuencia de la debilidad ósea por la pérdida de DMO. A pesar de que hay estudios que relacionan la litiasis con la osteoporosis, el nexo de causalidad no se ha podido establecer de forma correcta por la dificultad de realizar estudios prospectivos con años de seguimiento. Sin embargo, este grupo de pacientes con litiasis-osteoporosis está bien estudiado desde el punto de vista clínico y analítico. Por el contrario, existen muy pocos datos y estudios relevantes en la literatura que analicen la presencia de factores litogénicos en un grupo de pacientes con fractura osteoporótica, por lo que no se conoce bien la utilidad o necesidad de solicitar estos marcadores en este grupo de pacientes. De ahí que la hipótesis de nuestro trabajo sea el estudio de las alteraciones litogénicas en orina para determinar sus cambios en pacientes con fractura osteoporótica., Tesis Univ. Granada. Departamento de Cirugía y sus Especialidades

Published
2016

7. Estudio de factores litogénicos en pacientes con fractura osteoporótica

Author

Ochoa-Hortal Rull, Miguel Ángel, Arrabal Polo, Miguel Ángel, and Universidad de Granada. Departamento de Cirugía y sus Especialidades

Subjects
Cirugía, 616.7, Fractura osteoporótica, Osteoporosis, Fracturas, Litogénico, Fisiología patológica, 616.71
Abstract

Several studies in the literature have shown a relationship between osteopenia/osteoporosis and calcium nephrolithiasis. Apart from this clinical relationship, patients with recurrent calcium nephrolithiasis show altered markers of bone remodeling (bone formation and mainly resorption) and urinary lithogenic activity markers such as calciuria, citraturia, calcium/creatinine ratio and calcium/citrate ratio. Although the relationship and causality link between these two conditions is not well known, genetic, immunologic, inflammatory and dietetic factors could be facilitating the appearance and maintenance of the osteoporosis-renal lithiasis pairing. It seems that the presence of recurrent calcium nephrolithiasis is a risk factor in the development of bone fractures in patients with osteoporosis due to an increase of its accumulated incidence as time passes. The aim of this doctoral dissertation is to study the lithogenic factors in patients with osteoporotic fractures in order to determine if they are altered as compared to the general population., La osteoporosis es una enfermedad muy prevalente que se relaciona entre otras patologías con la litiasis renal de composición cálcica. Los pacientes con litiasis renal cálcica recidivante presentan un aumento en la pérdida de DMO O DENSIDAD MINERAL ÓSEA? que se expresa con la elevación de marcadores de remodelado óseo y con la presencia de hipercalciuria de ayunas e hipocitraturia entre otras alteraciones. Por su parte, los pacientes con osteoporosis expresan con frecuencia aumento de la excreción renal de calcio que representa un factor de riesgo litogénico. Una de las complicaciones más habituales de la osteoporosis es la aparición de fractura como consecuencia de la debilidad ósea por la pérdida de DMO. A pesar de que hay estudios que relacionan la litiasis con la osteoporosis, el nexo de causalidad no se ha podido establecer de forma correcta por la dificultad de realizar estudios prospectivos con años de seguimiento. Sin embargo, este grupo de pacientes con litiasis-osteoporosis está bien estudiado desde el punto de vista clínico y analítico. Por el contrario, existen muy pocos datos y estudios relevantes en la literatura que analicen la presencia de factores litogénicos en un grupo de pacientes con fractura osteoporótica, por lo que no se conoce bien la utilidad o necesidad de solicitar estos marcadores en este grupo de pacientes. De ahí que la hipótesis de nuestro trabajo sea el estudio de las alteraciones litogénicas en orina para determinar sus cambios en pacientes con fractura osteoporótica., Tesis Univ. Granada. Departamento de Cirugía y sus Especialidades

Published
2016

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